Conformational analysis and molecular properties of N-(substituted phenyl-carbonylamino)-4-(1-hydroxymethylphenyl)-1,2,3,6-tetrahydropyridines

The three-dimensional structures of active derivatives of N-(substitutedphenylcarbonylamino)-4-(1-hydroxymethylphenyl)-1,2,3,6-tetrahydropyri-dines, which have previously been shown to possess anti-inflammatory activities, were built using BIOMEDCAche 5.0 software program. In addition, the three dim...

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Bibliographic Details
Published in:	Current medicinal chemistry Vol. 10; no. 4; p. 313
Main Authors:	Okoroa, Cosmas O, Wilsonb, Tiffany L, Redda, Kinfe K
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-02-2003
Subjects:	Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - chemistry Models, Molecular Molecular Conformation Pyridines - chemical synthesis Pyridines - chemistry Structure-Activity Relationship
Online Access:	Get more information
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Summary:	The three-dimensional structures of active derivatives of N-(substitutedphenylcarbonylamino)-4-(1-hydroxymethylphenyl)-1,2,3,6-tetrahydropyri-dines, which have previously been shown to possess anti-inflammatory activities, were built using BIOMEDCAche 5.0 software program. In addition, the three dimensional structures of some of the inactive ones were similarly generated. The conformational analysis, molecular and electronic structures were examined by molecular mechanics and quantum mechanics calculations. The primary objective was to clarify the effects of physicochemical properties of substituents on activity, since the exact role of the substitution pattern on the phenyl ring is uncertain. In addition, the experimental log P values did not appear to have any influence on the anti-inflammatory potencies of these compounds, since compounds having differing lipid solubilities are equiactive. We found that strongly electron-donating group, such as the para-substituted methoxy group, detracts from activity. The conformational analysis indicated that the 4-ethyl derivative had the lowest energy conformation. Except for compound 1, which showed the lowest surface volume, compounds 2-9 had nearly similar surface volumes.
ISSN:	0929-8673
DOI:	10.2174/0929867033368303