Search Results - "Okoro, Jeffrey J"

KRASQ61H Preferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non–Small Cell Lung Cancer by Zhou, Zhi-Wei, Ambrogio, Chiara, Bera, Asim K., Li, Qing, Li, Xing-Xiao, Li, Lianbo, Son, Jieun, Gondi, Sudershan, Li, Jiaqi, Campbell, Emily, Jin, Hua, Okoro, Jeffrey J., Xu, Cheng-Xiong, Janne, Pasi A., Westover, Kenneth D.

“…Abstract Assembly of RAS molecules into complexes at the cell membrane is critical for RAS signaling. We previously showed that oncogenic KRAS codon 61…”
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A structural model of a Ras–Raf signalosome by Mysore, Venkatesh P., Zhou, Zhi-Wei, Ambrogio, Chiara, Li, Lianbo, Kapp, Jonas N., Lu, Chunya, Wang, Qi, Tucker, Maxwell R., Okoro, Jeffrey J., Nagy-Davidescu, Gabriela, Bai, Xiaochen, Plückthun, Andreas, Jänne, Pasi A., Westover, Kenneth D., Shan, Yibing, Shaw, David E.

“…The protein K-Ras functions as a molecular switch in signaling pathways regulating cell growth. In the human mitogen-activated protein kinase (MAPK) pathway,…”
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Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer by Ricciuti, Biagio, Son, Jieun, Okoro, Jeffrey J, Mira, Alessia, Patrucco, Enrico, Eum, Yoonji, Wang, Xinan, Paranal, Raymond, Wang, Haiyun, Lin, Mika, Haikala, Heidi M, Li, Jiaqi, Xu, Yue, Alessi, Joao Victor, Chhoeu, Chhayheng, Redig, Amanda J, Köhler, Jens, Dholakia, Kshiti H, Chen, Yunhan, Richard, Elodie, Nokin, Marie-Julie, Santamaria, David, Gokhale, Prafulla C, Awad, Mark M, Jänne, Pasi A, Ambrogio, Chiara

“…Activating missense mutations of KRAS are the most frequent oncogenic driver events in lung adenocarcinoma (LUAD). However, KRAS isoforms are highly…”
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Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer by Eser, Pınar Özden, Paranal, Raymond M, Son, Jieun, Ivanova, Elena, Kuang, Yanan, Haikala, Heidi M, To, Ciric, Okoro, Jeffrey J, Dholakia, Kshiti H, Choi, Jihyun, Eum, Yoonji, Ogino, Atsuko, Missios, Pavlos, Ercan, Dalia, Xu, Man, Poitras, Michael J, Wang, Stephen, Ngo, Kenneth, Dills, Michael, Yanagita, Masahiko, Lopez, Timothy, Lin, Mika, Tsai, Jeanelle, Floch, Nicolas, Chambers, Emily S, Heng, Jennifer, Anjum, Rana, Santucci, Alison D, Michael, Kesi, Schuller, Alwin G, Cross, Darren, Smith, Paul D, Oxnard, Geoffrey R, Barbie, David A, Sholl, Lynette M, Bahcall, Magda, Palakurthi, Sangeetha, Gokhale, Prafulla C, Paweletz, Cloud P, Daley, George Q, Jänne, Pasi A

“…The clinical efficacy of epidermal growth factor receptor (EGFR)–targeted therapy in -mutant non–small cell lung cancer is limited by the development of drug…”
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KRAS Q61H Preferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non-Small Cell Lung Cancer by Zhou, Zhi-Wei, Ambrogio, Chiara, Bera, Asim K, Li, Qing, Li, Xing-Xiao, Li, Lianbo, Son, Jieun, Gondi, Sudershan, Li, Jiaqi, Campbell, Emily, Jin, Hua, Okoro, Jeffrey J, Xu, Cheng-Xiong, Janne, Pasi A, Westover, Kenneth D

“…Assembly of RAS molecules into complexes at the cell membrane is critical for RAS signaling. We previously showed that oncogenic KRAS codon 61 mutations…”
Get full text