Search Results - "Okonkwo, David"

Telling the Whole Story: Bibliometric Network Analysis to Evaluate Impact of Media Attention on Chronic Traumatic Encephalopathy Research by Eagle, Shawn R, Okonkwo, David O

“…There is a national debate regarding the existence of a relationship between contact sport participation and future risk of neurodegenerative disease. We…”
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Prognostic Models for Traumatic Brain Injury Have Good Discrimination but Poor Overall Model Performance for Predicting Mortality and Unfavorable Outcomes by Eagle, Shawn R, Pease, Matthew, Nwachuku, Enyinna, Deng, Hansen, Okonkwo, David O

“…The most extensively validated prognostic models for traumatic brain injury (TBI) are the Corticoid Randomization after Significant Head Injury (CRASH) and…”
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Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial by Okonkwo, David O., Shutter, Lori A., Moore, Carol, Temkin, Nancy R., Puccio, Ava M., Madden, Christopher J., Andaluz, Norberto, Chesnut, Randall M., Bullock, M. Ross, Grant, Gerald A., McGregor, John, Weaver, Michael, Jallo, Jack, LeRoux, Peter D., Moberg, Dick, Barber, Jason, Lazaridis, Christos, Diaz-Arrastia, Ramon R.

“…A relationship between reduced brain tissue oxygenation and poor outcome following severe traumatic brain injury has been reported in observational studies. We…”
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Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study by Bazarian, Jeffrey J, Biberthaler, Peter, Welch, Robert D, Lewis, Lawrence M, Barzo, Pal, Bogner-Flatz, Viktoria, Gunnar Brolinson, P, Büki, Andras, Chen, James Y, Christenson, Robert H, Hack, Dallas, Huff, J Stephen, Johar, Sandeep, Jordan, J Dedrick, Leidel, Bernd A, Lindner, Tobias, Ludington, Elizabeth, Okonkwo, David O, Ornato, Joseph, Peacock, W Frank, Schmidt, Kara, Tyndall, Joseph A, Vossough, Arastoo, Jagoda, Andy S

“…More than 50 million people worldwide sustain a traumatic brain injury (TBI) annually. Detection of intracranial injuries relies on head CT, which is overused…”
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Intracranial pressure thresholds in severe traumatic brain injury: we are not sure: Prudent clinical practice despite dogma or nihilism by Stocchetti, Nino, Poole, Daniele, Okonkwo, David O.

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In Reply: Prognostic Models for Traumatic Brain Injury Have Good Discrimination But Poor Overall Model Performance for Predicting Mortality and Unfavorable Outcomes by Eagle, Shawn R, Okonkwo, David O

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Complications from Multimodal Monitoring Do not Affect Long-Term Outcomes in Severe Traumatic Brain Injury by Pease, Matthew, Nwachuku, Enyinna, Goldschmidt, Ezequiel, Elmer, Jonathan, Okonkwo, David O.

“…Invasive neuromonitoring is a mainstay of modern management of severe traumatic brain injury (TBI). Complication rates of neuromonitor placement are widely…”
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Central Cord Syndrome Is Likewise a Surgical Emergency-Time Is Spine by Okonkwo, David O, Mushlin, Harry M

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Rho Inhibitor VX-210 in Acute Traumatic Subaxial Cervical Spinal Cord Injury: Design of the SPinal Cord Injury Rho INhibition InvestiGation (SPRING) Clinical Trial by Fehlings, Michael G, Kim, Kee D, Aarabi, Bizhan, Rizzo, Marco, Bond, Lisa M, McKerracher, Lisa, Vaccaro, Alexander R, Okonkwo, David O

“…Traumatic spinal cord injury (SCI) is associated with a lifetime of disability stemming from loss of motor, sensory, and autonomic functions; these losses,…”
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Emerging Safety of Intramedullary Transplantation of Human Neural Stem Cells in Chronic Cervical and Thoracic Spinal Cord Injury by Levi, Allan D, Okonkwo, David O, Park, Paul, Jenkins, Arthur L, Kurpad, Shekar N, Parr, Ann M, Ganju, Aruna, Aarabi, Bizhan, Kim, Dong, Casha, Steven, Fehlings, Michael G, Harrop, James S, Anderson, Kim D, Gage, Allyson, Hsieh, Jane, Huhn, Stephen, Curt, Armin, Guzman, Raphael

“…Abstract BACKGROUND Human central nervous system stem cells (HuCNS-SC) are multipotent adult stem cells with successful engraftment, migration, and…”
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Magnetic resonance imaging improves 3-month outcome prediction in mild traumatic brain injury by Yuh, Esther L., Mukherjee, Pratik, Lingsma, Hester F., Yue, John K., Ferguson, Adam R., Gordon, Wayne A., Valadka, Alex B., Schnyer, David M., Okonkwo, David O., Maas, Andrew I. R., Manley, Geoffrey T.

“…Objective To determine the clinical relevance, if any, of traumatic intracranial findings on early head computed tomography (CT) and brain magnetic resonance…”
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Applying the Sliding Scale Approach to Quantifying Functional Outcomes Up to Two Years After Severe Traumatic Brain Injury by Eagle, Shawn R, Nwachuku, Enyinna, Deng, Hansen, Okonkwo, David O, Elmer, Justin, Pease, Matthew

“…Outcomes after severe traumatic brain injury (TBI) can be represented by a sliding score that compares actual functional recovery to that predicted by illness…”
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Letter to the Editor: Caveats for the Unconventional Animal Model of Chronic Traumatic Encephalopathy: A Bridge Too Far? by Eagle, Shawn R, Kofler, Julia, Okonkwo, David O

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Response to Daneshvar and Rovito, " Letter to the Editor: Telling the Whole Story: Articles Linking Chronic Traumatic Encephalopathy and Repetitive Head Impacts Have Higher Journal Impact Factors" (DOI: 10.1089/neu.2022.0374) by Eagle, Shawn R, Okonkwo, David O

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Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae by Albayram, Onder, Kondo, Asami, Mannix, Rebekah, Smith, Colin, Tsai, Cheng-Yu, Li, Chenyu, Herbert, Megan K., Qiu, Jianhua, Monuteaux, Michael, Driver, Jane, Yan, Sandra, Gormley, William, Puccio, Ava M., Okonkwo, David O., Lucke-Wold, Brandon, Bailes, Julian, Meehan, William, Zeidel, Mark, Lu, Kun Ping, Zhou, Xiao Zhen

“…Traumatic brain injury (TBI) is characterized by acute neurological dysfunction and associated with the development of chronic traumatic encephalopathy (CTE)…”
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Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study by Hartings, Jed A, Dr, Bullock, M Ross, MD, Okonkwo, David O, MD, Murray, Lilian S, PhD, Murray, Gordon D, PhD, Fabricius, Martin, DMSc, Maas, Andrew IR, MD, Woitzik, Johannes, MD, Sakowitz, Oliver, MD, Mathern, Bruce, MD, Roozenbeek, Bob, MD, Lingsma, Hester, PhD, Dreier, Jens P, MD, Puccio, Ava M, PhD, Shutter, Lori A, MD, Pahl, Clemens, MD, Strong, Anthony J, MD

“…Summary Background Pathological waves of spreading mass neuronal depolarisation arise repeatedly in injured, but potentially salvageable, grey matter in 50–60%…”
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Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma by HINZMAN, Jason M, ANDALUZ, Norberto, SHUTTER, Lori A, OKONKWO, David O, PAHL, Clemens, STRONG, Anthony J, DREIER, Jens P, HARTINGS, Jed A

“…Cortical spreading depolarization causes a breakdown of electrochemical gradients following acute brain injury, and also elicits dynamic changes in regional…”
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Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau-Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers by Rubenstein, Richard, Chang, Binggong, Yue, John K, Chiu, Allen, Winkler, Ethan A, Puccio, Ava M, Diaz-Arrastia, Ramon, Yuh, Esther L, Mukherjee, Pratik, Valadka, Alex B, Gordon, Wayne A, Okonkwo, David O, Davies, Peter, Agarwal, Sanjeev, Lin, Fan, Sarkis, George, Yadikar, Hamad, Yang, Zhihui, Manley, Geoffrey T, Wang, Kevin K W, Cooper, Shelly R, Dams-O'Connor, Kristen, Borrasso, Allison J, Inoue, Tomoo, Maas, Andrew I R, Menon, David K, Schnyer, David M, Vassar, Mary J

“…Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is…”
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Sub-classifying patients with mild traumatic brain injury: A clustering approach based on baseline clinical characteristics and 90-day and 180-day outcomes by Si, Bing, Dumkrieger, Gina, Wu, Teresa, Zafonte, Ross, Valadka, Alex B, Okonkwo, David O, Manley, Geoffrey T, Wang, Lujia, Dodick, David W, Schwedt, Todd J, Li, Jing

“…The current classification of traumatic brain injury (TBI) into "mild", "moderate", or "severe" does not adequately account for the patient heterogeneity that…”
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Financial burden associated with the residency match in neurological surgery by Agarwal, Nitin, Choi, Phillip A, Okonkwo, David O, Barrow, Daniel L, Friedlander, Robert M

“…OBJECTIVE Application for a residency position in neurosurgery is a highly competitive process. Visiting subinternships and interviews are integral parts of…”
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