Anti-inflammatory and antinociceptive activities of Homalium letestui

Homalium letestui Pellegr (Flacourtiaceae) is used in various decoctions traditionally by the Ibibios of the Niger Delta of Nigeria to treat stomach ulcer, malaria and other inflammatory diseases, as well as an aphrodisiac. To investigate the anti-inflammatory and antinociceptive activities of the s...

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Bibliographic Details
Published in:	Pharmaceutical biology Vol. 51; no. 11; p. 1459
Main Authors:	Okokon, Jude E, Okokon, Patience J, Dar Farooq, Ahsana, Choudhary, Mohammed Iqbal
Format:	Journal Article
Language:	English
Published:	England 01-11-2013
Subjects:	Administration, Oral Analgesics - administration & dosage Analgesics - chemistry Analgesics - pharmacology Analgesics - toxicity Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - toxicity Behavior, Animal - drug effects Disease Models, Animal Dose-Response Relationship, Drug Edema - chemically induced Edema - prevention & control Ethanol - chemistry Female Flacourtiaceae Gas Chromatography-Mass Spectrometry Inflammation - chemically induced Inflammation - prevention & control Lethal Dose 50 Male Mice Pain - chemically induced Pain - physiopathology Pain - prevention & control Pain Threshold - drug effects Phytotherapy Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - toxicity Plant Stems Plants, Medicinal Rats Rats, Wistar Solvents - chemistry
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Summary:	Homalium letestui Pellegr (Flacourtiaceae) is used in various decoctions traditionally by the Ibibios of the Niger Delta of Nigeria to treat stomach ulcer, malaria and other inflammatory diseases, as well as an aphrodisiac. To investigate the anti-inflammatory and antinociceptive activities of the stem extract of the plant. The ethanol stem extract (500, 750, 1000 mg/kg, i.p.) of H. letestui was investigated for anti-inflammatory activity using carrageenan, egg albumin-induced and xylene-induced ear edema models and analgesic activity using acetic acid-induced writhing, formalin-induced paw licking and thermal-induced pain models. The ethanol extract was administered to the animals orally, 30 min to 1 h depending on the model, before induction of inflammation/pain. The LD50 was also determined. GC-MS analysis of dichloromethane fraction was carried out. The extract caused a significant (p < 0.05-0.001) reduction of inflammation induced by carrageenan (8.3-70.0%), egg albumin (10.0-71.42%) and xylene (39.39-84.84%). The extract also reduced significantly (p < 0.05-0.001) pain induced by acetic acid (44.22-73.65%), formalin (55.89-79.21%) and hot plate (93.0-214.5%). The LD50 was determined to be 4.38 ± 35.72 g/kg. The results of this study suggest that the ethanol stem extract of H. letestui possesses anti-inflammatory and analgesic properties which may in part be mediated through the chemical constituents of the plant as revealed by the GC-MS.
ISSN:	1744-5116
DOI:	10.3109/13880209.2013.799707