Abstract 9578: Cholesterol Embolization Syndrome Among Patients With Acute Coronary Syndrome Post-Percutaneous Coronary Intervention: A National Inpatient Analysis

IntroductionPercutaneous coronary intervention (PCI) is associated with an increased risk of cholesterol embolization syndrome (CES), accounting for approximately 70% of iatrogenic cholesterol embolization. The clinical outcomes of patients with acute coronary syndrome (ACS), who develop CES post-PC...

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Published in:	Circulation (New York, N.Y.) Vol. 144; no. Suppl_1; p. A9578
Main Authors:	Eromosele, Oseiwe B, ASEMOTA, IRIAGBONSE, SAFIRIYU, ISRAEL, Ajibade, Ademola, Abib, Oluwole S, Idowu, Abiodun B, Adebolu, Olayinka I, Okoh, Nelson C, Lukan, Abdulkareem, Fasanmi, Oluwafisayo S, Odeyinka, Oladipo, Babayale, Omofolarin, Abu, Hawa O
Format:	Journal Article
Language:	English
Published:	Lippincott Williams & Wilkins 16-11-2021
Online Access:	Get full text
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Summary:	IntroductionPercutaneous coronary intervention (PCI) is associated with an increased risk of cholesterol embolization syndrome (CES), accounting for approximately 70% of iatrogenic cholesterol embolization. The clinical outcomes of patients with acute coronary syndrome (ACS), who develop CES post-PCI is yet to be explored on a national scale. ObjectivesTo evaluate the length of hospital stay (LOS), cost of hospitalization; proportion of patients with acute kidney injury (AKI), sepsis, cardiogenic shock and in-hospital mortality among those with ACS who develop CES post-PCI. MethodsAdults who had a diagnosis of ACS and PCI done who eventually had CES, were identified from the National In-Patient Sample (NIS) dataset between 2016-2018 using ICD10 codes. Weighted multivariable logistic and linear regression models were used as appropriate. Various sociodemographic, clinical and hospital level factors were adjusted for in the analysis. ResultsOf the 365 patients who had ACS and developed CES post-PCI; 48% were women, 76.7% were non-Hispanic White and the average age was 69.5 years. The mean LOS was 8.2 days and the mean cost of hospitalization was $99,958.02. Overall, 32.9% of the patients developed AKI, 6.8% developed sepsis, 4.1% subsequently had cardiogenic shock and 11% had in-hospital mortality. ConclusionsOur study highlights important patient characteristics, resource utilization and clinical outcomes among patients with ACS who develop CES post-PCI, which provides relevant information needed to generate hypothesis linked to this disease condition.
ISSN:	0009-7322 1524-4539
DOI:	10.1161/circ.144.suppl_1.9578