Search Results - "Okogun, Joseph I"

21st century natural product research and drug development and traditional medicines by Ngo, Linh T, Okogun, Joseph I, Folk, William R

“…Natural products and related structures are essential sources of new pharmaceuticals, because of the immense variety of functionally relevant secondary…”
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Hypoestoxide inhibits tumor growth in the mouse CT26 colon tumor model by Ojo-Amaize, Emmanuel A, Cottam, Howard B, Oyemade, Olusola A, Okogun, Joseph I, Nchekwube, Emeka J

“…To evaluate the effect of the natural diterpenoid, hypoestoxide (HE) on the growth of established colon cancer in mice. The CT26.WT mouse colon carcinoma cell…”
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Tirucallane triterpenes from the leaf extract of Entandrophragma angolense by Orisadipe, Abayomi T., Adesomoju, Akinbobola A., D’Ambrosio, Michele, Guerriero, Antonio, Okogun, Joseph I.

“…Three new protolimonoids are described, two of them possessing the rare ring-A-seco feature. From the leaves of Entandrophragma angolense, three triterpenoidal…”
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Some Nigerian anti-tuberculosis ethnomedicines: A preliminary efficacy assessment by Ibekwe, Nneka N., Nvau, John B., Oladosu, Peters O., Usman, Auwal M., Ibrahim, Kolo, Boshoff, Helena I., Dowd, Cynthia S., Orisadipe, Abayomi T., Aiyelaagbe, Olapeju, Adesomoju, Akinbo A., Barry, Clifton E., Okogun, Joseph I.

“…Nigerian herbalists possess indigenous ethnomedicinal recipes for the management of tuberculosis and related ailments. A collaborative preliminary modern…”
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An unprecedented gedunin rearrangement reaction converts a methyl group into the methylene group of a cyclopropyl ring by Okhale, Samuel E., Decatur, John, Itagaki, Yasuhiro, Amupitan, Joseph O., Ndukwe, George I., Ellestad, George, Okogun, Joseph I.

“…Herein we describe an unprecedented formation of a cyclopropane ring through the conversion of a methyl group that was not functionalized for the purpose. In a…”
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Antioxidant and drug detoxification potentials of Hibiscus sabdariffa anthocyanin extract by Ajiboye, Taofeek O., Salawu, Nasir A., Yakubu, Musa T., Oladiji, Adenike T., Akanji, Musbau A., Okogun, Joseph I.

“…The antioxidant and drug metabolizing potentials of Hibiscus anthocyanin extract in CCl4- induced oxidative damage of rat liver was investigated. Hibiscus…”
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Antioxidant and drug detoxification potential of aqueous extract of Annona senegalensis leaves in carbon tetrachloride-induced hepatocellular damage by Ajboye, Taofeek O, Yakubu, Musa T, Salau, Amadu K, Oladiji, Adenike T, Akanji, Musbau A, Okogun, Joseph I

“…Despite the myriad uses of Annona senegalensis Pers. (Annonaceae) leaves in folklore medicine of Nigeria, the basis is yet to be substantiated by scientific…”
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In vivo trypanocidal activity of Annona senegalensis Pers. leaf extract against Trypanosoma brucei brucei by Ogbadoyi, Emmanuel O., Abdulganiy, Akinsunbo O., Adama, Theophilus Z., Okogun, Joseph I.

“…Chemotherapy of African trypanosomiasis still remains far from being satisfactory. There is the urgent need for therapeutic agents that are effective,…”
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Chemical constituents and antimycobacterial studies of the leaf extracts of Pavetta crassipes K. Schum by Ibekwe, Nneka N., Boshoff, Helena, Randle, Joaquin, Adesomoju, Akinbo A., Barry, Clifton E. III, Okogun, Joseph I.

“…Six known compounds; β-sitosterol, ursolic acid, methyl chlorogenate, ethyl chlorogenate, rutin and mannitol were isolated from the leaf extracts of Pavetta…”
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Acetaminophen perturbed redox homeostasis in Wistar rat liver: protective role of aqueous Pterocarpus osun leaf extract by Ajiboye, Taofeek O., Salau, Amadu K., Yakubu, Musa T., Oladiji, Adenike T., Akanji, Musbau A., Okogun, Joseph I.

“…This study investigates the in vitro antioxidant potentials and attenuation of acetaminophen-induced redox imbalance by Pterocarpus osun Craib (Fabaceae) leaf…”
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Plasmodium berghei: Antiparasitic effects of orally administered Hypoestoxide in mice by Ojo-Amaize, Emmanuel A., Nchekwube, Emeka J., Cottam, Howard B., Oyemade, Olusola A., Adesomoju, Akinbo A., Okogun, Joseph I.

“…Hypoestoxide (HE) is a diterpene isolated from H ypoestes rosea (Acanthaceae), a plant indigenous to Nigeria. Previous studies demonstrated that HE exhibited…”
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Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: Possible mechanisms of action by OJO-AMAIZE, Emmanuel A, NCHEKWUBE, Emeka J, OYEMADE, Olusola A, HAMEL, Ernest, COTTAM, Howard B, BAI, Ruoli, VERDIER-PINARD, Pascal, KAKKANAIAH, Vellalore N, VARNER, Judith A, LEONI, Lorenzo, OKOGUN, Joseph I, ADESOMOJU, Akinbo A

“…We have shown previously that hypoestoxide (HE), a natural diterpenoid [a bicyclo (9, 3, 1) pentadecane], is a potent nonsteroidal anti-inflammatory drug. In…”
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Effect of oral administration of aqueous whole extract of cassytha filiformis on haematograms and plasma biochemical parameters in rats by Babayi, Hausatu M, Udeme, Joseph J I, Abalaka, Joseph A, Okogun, Joseph I, Salawu, O A, Akumka, David D, Adamu, Zarma, Sunday S, Adzu, Bulus B, Abdulmumuni, Sabo S, Ibrahime, Kolo, Elisha, Baba B, Zakariys, Samuel S, Inyang, Uford S

“…We evaluated the sub-chronic toxicity of the aqueous herbal extract prepared from Cassytha filiformis and administered daily for 28 days at dose levels (250,…”
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Use of 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole for Determining Cysteine and Cystine in Cereal and Legume Seeds by Akinyele, Ayoni F, Okogun, Joseph I, Faboya, Olufemi P

“…A new colorimetric method has been developed for the determination of chemically available cysteine and half-cystine in maize and legume seeds. The method is…”
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Roseatoxide and Dihypoestoxide: Additional New Diterpenoids from Hypoestes rosea by Adesomoju, Akinbo A, Okogun, Joseph I

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The Chemical Constituents of Musanga cecropioides by Ojinnaka, Chukwunonye M, Okogun, Joseph I

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Nkolbisine, a New Furoquinoline Alkaloid, and 7-Deacetylazadirone From Teclea verdoorniana by Ayafor, Johnson Foyere, Okogun, Joseph I

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Acetaminophen perturbed redox homeostasis in Wistar rat liver: protective role of aqueous Pterocarpus osun leaf extract by Ajiboye, Taofeek O., Salau, Amadu K., Yakubu, Musa T., Oladiji, Adenike T., Akanji, Musbau A., Okogun, Joseph I.

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Furoquinoline Alkaloids of Teclea ouabanguiensis by Ayafor, J. Foyere, Sondengam, B. Lucas, Bilon, A. Ngo, Tsamo, E, Kimbu, Samuel F, Okogun, Joseph I

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Hypoestoxide, a new diterpene from hypoestes rosea (Acanthaceae) by ADESOMOJU, A. A, OKOGUN, J. I, CAVA, M. P, CARROLL, P. J

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