Search Results - "Okita, Naoyuki"

Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways by Mizunoe, Yuhei, Kobayashi, Masaki, Sudo, Yuka, Watanabe, Shukoh, Yasukawa, Hiromine, Natori, Daiki, Hoshino, Ayana, Negishi, Arisa, Okita, Naoyuki, Komatsu, Masaaki, Higami, Yoshikazu

“…Dysfunction of autophagy, which regulates cellular homeostasis by degrading organelles and proteins, is associated with pathogenesis of various diseases such…”
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Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue by Fujii, Namiki, Uta, Seira, Kobayashi, Masaki, Sato, Tsugumichi, Okita, Naoyuki, Higami, Yoshikazu

“…Caloric restriction (CR) suppresses age-related pathophysiology and extends lifespan. We recently reported that metabolic remodeling of white adipose tissue…”
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Heat shock‐induced heme oxygenase‐1 expression in a mouse hepatoma cell line is dependent on HSF1 and modified by NRF2 and BACH1 by Inouye, Sachiye, Kubo, Takanori, Miyamoto, Takafumi, Iyoda, Takuya, Okita, Naoyuki, Akagi, Reiko

“…The induction mechanism of heme oxygenase‐1 (HO‐1) by heat shock (HS) is still unknown. Here, we discovered that HS activates the HO‐1 expression in a mouse…”
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Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice by Mizunoe, Yuhei, Sudo, Yuka, Okita, Naoyuki, Hiraoka, Hidenori, Mikami, Kentaro, Narahara, Tomohiro, Negishi, Arisa, Yoshida, Miki, Higashibata, Rikako, Watanabe, Shukoh, Kaneko, Hiroki, Natori, Daiki, Furuichi, Takuma, Yasukawa, Hiromine, Kobayashi, Masaki, Higami, Yoshikazu

“…Whether obesity accelerates or suppresses autophagy in adipose tissue is still debatable. To clarify dysregulation of autophagy and its role in pathologies of…”
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Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes by Mizunoe, Yuhei, Kobayashi, Masaki, Hoshino, Shunsuke, Tagawa, Ryoma, Itagawa, Rei, Hoshino, Ayana, Okita, Naoyuki, Sudo, Yuka, Nakagawa, Yoshimi, Shimano, Hitoshi, Higami, Yoshikazu

“…Obesity, caused by the dysfunction of white adipose tissue (WAT), is reportedly accompanied by exacerbation of lipolysis. Perilipin 1 (PLIN1), which forms a…”
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Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids by Tagawa, Ryoma, Kobayashi, Masaki, Sakurai, Misako, Yoshida, Maho, Kaneko, Hiroki, Mizunoe, Yuhei, Nozaki, Yuka, Okita, Naoyuki, Sudo, Yuka, Higami, Yoshikazu

“…Cholesterol is an essential lipid in vertebrates, but excess blood cholesterol promotes atherosclerosis. In the liver, cholesterol is metabolized to bile acids…”
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Bioactive TNIIIA2 Sequence in Tenascin-C Is Responsible for Macrophage Foam Cell Transformation; Potential of FNIII14 Peptide Derived from Fibronectin in Suppression of Atherosclerotic Plaque Formation by Iyoda, Takuya, Ohishi, Asayo, Wang, Yunong, Yokoyama, Miyabi-Shara, Kazama, Mika, Okita, Naoyuki, Inouye, Sachiye, Nakagawa, Yoshimi, Shimano, Hitoshi, Fukai, Fumio

“…One of the extracellular matrix proteins, tenascin-C (TN-C), is known to be upregulated in age-related inflammatory diseases such as cancer and cardiovascular…”
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Modified Western blotting for insulin and other diabetes-associated peptide hormones by Okita, Naoyuki, Higami, Yoshikazu, Fukai, Fumio, Kobayashi, Masaki, Mitarai, Miku, Sekiya, Takao, Sasaki, Takashi

“…Now, the quantification of proinsulin/insulin contents within organisms tends to be evaluated only by enzyme-linked immunosorbent assay (ELISA), although…”
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Differential response to caloric restriction of retroperitoneal, epididymal, and subcutaneous adipose tissue depots in rats by Narita, Takumi, Kobayashi, Masaki, Itakura, Kaho, Itagawa, Rei, Kabaya, Riho, Sudo, Yuka, Okita, Naoyuki, Higami, Yoshikazu

“…The beneficial actions of caloric restriction (CR) are partially mediated by metabolic remodeling of white adipose tissue (WAT). Recently, we showed that CR…”
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Sterol regulatory element‐binding protein‐1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction by Fujii, Namiki, Narita, Takumi, Okita, Naoyuki, Kobayashi, Masaki, Furuta, Yurika, Chujo, Yoshikazu, Sakai, Masahiro, Yamada, Atsushi, Takeda, Kanae, Konishi, Tomokazu, Sudo, Yuka, Shimokawa, Isao, Higami, Yoshikazu

“…Summary Caloric restriction (CR) can delay onset of several age‐related pathophysiologies and extend lifespan in various species, including rodents. CR also…”
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Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle by Mizunoe, Yuhei, Kobayashi, Masaki, Saito, Hiroki, Goto, Akifumi, Migitaka, Ryota, Miura, Kumi, Okita, Naoyuki, Sudo, Yuka, Tagawa, Ryoma, Yoshida, Miki, Umemori, Ai, Nakagawa, Yoshimi, Shimano, Hitoshi, Higami, Yoshikazu

“…Aging causes loss of skeletal muscle mass and function, which is called sarcopenia. While sarcopenia impairs the quality of life of older adults and is a major…”
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DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism by Okita, Naoyuki, Minato, Shota, Ohmi, Eri, Tanuma, Sei-ichi, Higami, Yoshikazu

“…► Ser296 phosphorylation of CHK1 is regulated by an ATR-dependent pathway. ► CHK1 autophosphorylates at Ser296 via an intramolecular mechanism. ► Ser296…”
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The Poly(Adenosine Diphosphate-Ribose) Polymerase Inhibitor PJ34 Reduces Pulmonary Ischemia-Reperfusion Injury in Rats by Hatachi, Go, Tsuchiya, Tomoshi, Miyazaki, Takuro, Matsumoto, Keitaro, Yamasaki, Naoya, Okita, Naoyuki, Nanashima, Atsushi, Higami, Yoshikazu, Nagayasu, Takeshi

“…BACKGROUNDIschemia-reperfusion (I/R) injury after lung transplantation causes alveolar damage, lung edema, and acute rejection. Poly(adenosine…”
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Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia by Sudo, Yuka, Otsuka, Hiroki, Miyakawa, Ryota, Goto, Akifumi, Kashiwase, Yohei, Terawaki, Kiyoshi, Miyano, Kanako, Hirao, Yuto, Taki, Kanari, Tagawa, Ryoma, Kobayashi, Masaki, Okita, Naoyuki, Uezono, Yasuhito, Higami, Yoshikazu

“…Despite the similar phenotypes, including weight loss, reduction of food intake, and lower adiposity, associated with caloric restriction (CR) and cancer…”
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Phosphorylation of histone H2AX at M phase in human cells without DNA damage response by Ichijima, Yosuke, Sakasai, Ryo, Okita, Naoyuki, Asahina, Kinji, Mizutani, Shuki, Teraoka, Hirobumi

“…A variant of histone H2A, H2AX, is phosphorylated on Ser139 in response to DNA double-strand breaks (DSBs), and clusters of the phosphorylated form of H2AX…”
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Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes by Kobayashi, Masaki, Yasukawa, Hiromine, Arikawa, Tomoya, Deguchi, Yusuke, Mizushima, Natsumi, Sakurai, Misako, Onishi, Shoichi, Tagawa, Ryoma, Sudo, Yuka, Okita, Naoyuki, Higashi, Kyohei, Higami, Yoshikazu

“…Trehalose is a disaccharide reported to ameliorate adipocyte hypertrophy and improve metabolic state. The present study demonstrated that trehalose augments…”
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Inhibitory effect of p53 on mitochondrial content and function during adipogenesis by Okita, Naoyuki, Ishikawa, Natsumi, Mizunoe, Yuhei, Oku, Misako, Nagai, Wataru, Suzuki, Yuki, Matsushima, Shingo, Mikami, Kentaro, Okado, Hitoshi, Sasaki, Takashi, Higami, Yoshikazu

“…•We focused on mitochondrial regulation of p53 in adipocytes and myotubes.•In 3T3-L1 preadipocytes, p53 upregulation downregulates the expression of…”
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Differential responses of white adipose tissue and brown adipose tissue to caloric restriction in rats by Okita, Naoyuki, Hayashida, Yusuke, Kojima, Yumiko, Fukushima, Mayumi, Yuguchi, Keiko, Mikami, Kentaro, Yamauchi, Akiko, Watanabe, Kyoko, Noguchi, Mituru, Nakamura, Megumi, Toda, Toshifusa, Higami, Yoshikazu

“…► The remodeling of white and brown adipose tissues of CR rats was examined. ► CR affected mitochondrial function of both adipose tissues differentially. ► We…”
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WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism by Hoshino, Shunsuke, Kobayashi, Masaki, Tagawa, Ryoma, Konno, Ryutaro, Abe, Takuro, Furuya, Kazuhiro, Miura, Kumi, Wakasawa, Hiroki, Okita, Naoyuki, Sudo, Yuka, Mizunoe, Yuhei, Nakagawa, Yoshimi, Nakamura, Takeshi, Kawabe, Hiroshi, Higami, Yoshikazu

“…White adipose tissue (WAT) is important for maintenance of homeostasis, because it stores energy and secretes adipokines. The WAT of obese people demonstrates…”
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Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats by Okita, Naoyuki, Tsuchiya, Takuro, Fukushima, Mayumi, Itakura, Kaho, Yuguchi, Keiko, Narita, Takumi, Hashizume, Yukari, Sudo, Yuka, Chiba, Takuya, Shimokawa, Isao, Higami, Yoshikazu

“…The beneficial actions of caloric restriction (CR) could be mediated in part by metabolic remodeling of white adipose tissue (WAT). Recently, we suggested that…”
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