Search Results - "Okita, Kouki"

Altered binding avidities and improved growth inhibitory effects of novel anti-HER3 mAb against human cancers in the presence of HER1-or HER2-targeted drugs by Okita, Kouki, Imai, Kazuki, Kato, Kazunori, Sugiura, Reiko, Endo, Yuichi, Masuko, Kazue, Tomioka, Yoshihisa, Masuko, Takashi

“…HER1-and HER2-targeted drugs are effective in cancer therapy, especially against lung, breast and colon malignancies; however, resistance of cancer cells to…”
Get full text

Antitumor effects of novel mAbs against cationic amino acid transporter 1 (CAT1) on human CRC with amplified CAT1 gene by Okita, Kouki, Hara, Yuta, Okura, Hiroshi, Hayashi, Hidemi, Sasaki, Yoko, Masuko, Sachiko, Kitadai, Eri, Masuko, Kazue, Yoshimoto, Soshi, Hayashi, Natsumi, Sugiura, Reiko, Endo, Yuichi, Okazaki, Shogo, Arai, Sayaka, Yoshioka, Toshiaki, Matsumoto, Toshiharu, Makino, Yasutaka, Komiyama, Hiromitsu, Sakamoto, Kazuhiro, Masuko, Takashi

“…Copy number alterations detected by comparative genomic hybridization (CGH) can lead to the identification of novel cancer‐related genes. We analyzed…”
Get full text

CD98 regulates the phosphorylation of HER2 and a bispecific anti‐HER2/CD98 antibody inhibits the growth signal of human breast cancer cells by Yamasaki, Akitaka, Maruyama‐Takahashi, Kumiko, Nishida, Kento, Okazaki, Shogo, Okita, Kouki, Akiyama, Yasutoshi, Suzuki, Hideaki, Endo, Yuichi, Masuko, Kazue, Masuko, Takashi, Tomioka, Yoshihisa

“…Human epidermal growth factor receptor (HER) family proteins are currently major targets of therapeutic monoclonal antibodies against various epithelial…”
Get full text

Dual‐targeting therapy against HER3/MET in human colorectal cancers by Yamasaki, Akitaka, Miyake, Rikuto, Hara, Yuta, Okuno, Hideki, Imaida, Takuya, Okita, Kouki, Okazaki, Shogo, Akiyama, Yasutoshi, Hirotani, Kenji, Endo, Yuichi, Masuko, Kazue, Masuko, Takashi, Tomioka, Yoshihisa

“…Background Colorectal cancer (CRC) is the most common malignancy in the world, and novel molecular targeted therapies for CRC have been vigorously pursued. We…”
Get full text

Separation of phosphoprotein isotypes having the same number of phosphate groups using phosphate-affinity SDS-PAGE by Kinoshita, Eiji, Kinoshita-Kikuta, Emiko, Matsubara, Mamoru, Yamada, Seiji, Nakamura, Hiro, Shiro, Yoshitsugu, Aoki, Yuri, Okita, Kouki, Koike, Tohru

“…Herein, we demonstrate the separation of phosphoprotein isotypes having the same number of phosphate groups using phosphate-affinity SDS-PAGE. The…”
Get full text

Promotion of malignant phenotype after disruption of the three-dimensional structure of cultured spheroids from colorectal cancer by Piulats, Jose M, Kondo, Jumpei, Endo, Hiroko, Ono, Hiromasa, Hagihara, Takeshi, Okuyama, Hiroaki, Nishizawa, Yasuko, Tomita, Yasuhiko, Ohue, Masayuki, Okita, Kouki, Oyama, Hidejiro, Bono, Hidemasa, Masuko, Takashi, Inoue, Masahiro

“…Individual and small clusters of cancer cells may detach from the edges of a main tumor and invade vessels, which can act as the origin of metastasis; however,…”
Get full text

Immuno-PET Imaging of HER3 in a Model in which HER3 Signaling Plays a Critical Role by Yuan, Qinghua, Furukawa, Takako, Tashiro, Takahiro, Okita, Kouki, Jin, Zhao-Hui, Aung, Winn, Sugyo, Aya, Nagatsu, Kotaro, Endo, Hiroko, Tsuji, Atsushi B, Zhang, Ming-Rong, Masuko, Takashi, Inoue, Masahiro, Fujibayashi, Yasuhisa, Saga, Tsuneo

“…HER3 is overexpressed in various carcinomas including colorectal cancer (CRC), which is associated with poor prognosis, and is involved in the development of…”
Get full text

Stochastic resonance effect observed in a vaccination game with effectiveness framework obeying the SIR process on a scale-free network by Okita, Kouki, Tatsukawa, Yuichi, Utsumi, Shinobu, Arefin, Md. Rajib, Hossain, Md. Anowar, Tanimoto, Jun

“…This study investigates a standard vaccination game presuming the repeated-season framework, in which we mutually merge the dynamics of disease spread, which…”
Get full text

Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers by Okita, Kouki, Okazaki, Shogo, Uejima, Shinya, Yamada, Erina, Kaminaka, Hiroki, Kondo, Misa, Ueda, Shiho, Tokiwa, Ryo, Iwata, Nami, Yamasaki, Akitaka, Hayashi, Natsumi, Ogura, Dai, Hirotani, Kenji, Yoshioka, Toshiaki, Inoue, Masahiro, Masuko, Kazue, Masuko, Takashi

“…Resistance of progressive cancers against chemotherapy is a serious clinical problem. In this context, human epidermal growth factor receptor 3 (HER3) can play…”
Get full text

Structure of human Fyn kinase domain complexed with staurosporine by Kinoshita, Takayoshi, Matsubara, Mamoru, Ishiguro, Hiroshi, Okita, Kouki, Tada, Toshiji

“…The tyrosine kinase Fyn is a member of the Src kinase family. Besides the role of Fyn in T cell signal transduction in concert with Lck, its excess activity in…”
Get full text

Crystal structure of human mono-phosphorylated ERK1 at Tyr204 by Kinoshita, Takayoshi, Yoshida, Ikuyo, Nakae, Setsu, Okita, Kouki, Gouda, Masaki, Matsubara, Mamoru, Yokota, Koichi, Ishiguro, Hiroshi, Tada, Toshiji

“…Extracellular signal-regulated kinase (ERK) is a member of the MAP kinase family, and can regulate several cellular responses. The isoforms ERK1 and ERK2 have…”
Get full text