Search Results - "Okimura, Keiko"

Examination of the Antimicrobial Peptide Myticalin A6 Active Site by Okimura, Keiko, Matsubara, Keiko, Suzuki, Rie, Ito, Hanako, Sato, Ayumi, Sugimoto, Kaori

“…In 2017, Leoni et al. reported myticalins as novel cationic linear antimicrobial peptides obtained from marine mussels. The authors focused on myticalin A6 (29…”
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Contribution of Each Amino Acid Residue in Polymyxin B3 to Antimicrobial and Lipopolysaccharide Binding Activity by Kanazawa, Kazushi, Sato, Yuki, Ohki, Kazuhiro, Okimura, Keiko, Uchida, Yoshiki, Shindo, Mitsuno, Sakura, Naoki

“…This study on the structure–activity relationship of polymyxin B, a cyclic peptide antibiotic, used sixteen synthetic polymyxin B3 analogs including alanine…”
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Semi-synthesis of Polymyxin B (2-10) and Colistin (2-10) Analogs Employing the Trichloroethoxycarbonyl (Troc) Group for Side Chain Protection of α,γ-Diaminobutyric Acid Residues by Okimura, Keiko, Ohki, Kazuhiro, Sato, Yuki, Ohnishi, Kuniharu, Sakura, Naoki

“…Improved strategies for the chemical conversion of natural polymyxin B and colistin to their N-terminal analogs are reported. First, the protection of the side…”
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Development of Des-Fatty Acyl-Polymyxin B Decapeptide Analogs with Pseudomonas aeruginosa-Specific Antimicrobial Activity by Katsuma, Naoko, Sato, Yuki, Ohki, Kazuhiro, Okimura, Keiko, Ohnishi, Kuniharu, Sakura, Naoki

“…Twelve N-terminal analogs of des-fatty acyl-polymyxin B (Des-FA-[X1]-PMB, X=various amino acids or peptides) were synthesized and examined for their…”
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Chemical Conversion of Natural Polymyxin B and Colistin to Their N-Terminal Derivatives by Okimura, Keiko, Ohki, Kazuhiro, Sato, Yuki, Ohnishi, Kuniharu, Uchida, Yoshiki, Sakura, Naoki

“…The chemical conversions of natural polymyxin B and colistin, which are fatty-acylated cyclic decapeptides, to polymyxin (2–10) and colistin (2–10) derivatives…”
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Hydrolytic Cleavage of Pyroglutamyl-peptide Bond. V. Selective Removal of Pyroglutamic Acid from Biologically Active Pyroglutamylpeptides in High Concentrations of Aqueous Methanesulfonic Acid by Kobayashi, Junko, Ohki, Kazuhiro, Okimura, Keiko, Hashimoto, Tadashi, Sakura, Naoki

“…Application of aqueous methanesulfonic acid (MSA) for selective chemical removal of pyroglutamic acid (pGlu) residue from five biologically active…”
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The Contribution of the N-Terminal Structure of Polymyxin B Peptides to Antimicrobial and Lipopolysaccharide Binding Activity by Sakura, Naoki, Itoh, Tatsuya, Uchida, Yoshiki, Ohki, Kazuhiro, Okimura, Keiko, Chiba, Kenzo, Sato, Yuki, Sawanishi, Hiroyuki

“…To elucidate the N-terminal structure–activity relationships of polymyxin B peptides, seven polymyxin B component peptides, the structures of which having been…”
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Hydrolytic Cleavage of Pyroglutamyl-peptide Bond. V. Selective Removal of Pyroglutamic Acid from Biologically Active Pyroglutamylpeptides in High Concentrations of Aqueous Methanesulfonic Acid by Junko KOBAYASHI, Kazuhiro OHKI, Keiko OKIMURA, Tadashi HASHIMOTO, Naoki SAKURA

“…Application of aqueous methanesulfonic acid (MSA) for selective chemical removal of pyroglutamic acid (pGlu) residue from five biologically active…”
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HPLC Analysis of Fatty Acyl-Glycine in the Aqueous Methanesulfonic Acid Hydrolysates of N-Terminally Fatty Acylated Peptides by Okimura, Keiko, Ohki, Kazuhiro, Nagai, Sotoo, Sakura, Naoki

“…Acylation with long-chain fatty acids is a common modification at the N-terminal glycine residues of natural proteins. In this work, we performed HPLC analysis…”
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Development of Des-Fatty Acyl-Polymyxin B Decapeptide Analogs with Pseudomonas aeruginosa-Specific Antimicrobial Activity by Naoko KATSUMA, Yuki SATO, Kazuhiro OHKI, Keiko OKIMURA, Kuniharu OHNISHI, Naoki SAKURA

“…Twelve N-terminal analogs of des-fatty acyl-polymyxin B (Des-FA-[X1]-PMB, X=various amino acids or peptides) were synthesized and examined for their…”
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Regioselective Hydrolytic Cleavage of N-Terminal Myristoyl-peptide by OKIMURA, Keiko, SUGIMOTO, Kaori, OHKI, Kazuhiro, SAKURA, Naoki, HASHIMOTO, Tadashi

“…To develop a simple chemical deblocking method for Myr-Gly-peptide, we investigated the susceptibility and stability of the internal peptide linkages of model…”
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Study on Surfactin, a Cyclic Depsipeptide. II. Synthesis of Surfactin B2 Produced by Bacillus natto KMD 2311 by NAGAI, Sotoo, OKIMURA, Keiko, KAIZAWA, Naohito, OHKI, Kazuhiro, KANATOMO, Shoichi

“…The total synthesis of surfactin B2, a cyclic depsipeptide isolated from Bacillus natto KMD 2311, was achieved to elucidate the absolute configuration of its…”
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Structure-Activity Relationships of Rat Neuromedin U for Smooth Muscle Contraction by SAKURA, Naoki, OHTA, Satoru, UCHIDA, Yoshiki, KUROSAWA, Katsuro, OKIMURA, Keiko, HASHIMOTO, Tadashi

“…Rat neuromedin U (r-NMU) and its fragment peptide amides were synthesized by solid-phase methodology. Using a chicken crop smooth muscle contraction assay, the…”
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Contractile Activity of Porcine Neuromedin U-25 and Various Neuromedin U-Related Peptide Fragments on Isolated Chicken Crop Smooth Muscle by OKIMURA, Keiko, SAKURA, Naoki, OHTA, Satoru, KUROSAWA, Katsuro, HASHIMOTO, Tadashi

“…Contractile activity of porcine neuromedin U-25 (p-NMU-25) and various neuromedin U (NMU) peptide fragment amides was examined on chicken crop smooth muscle…”
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Semi-synthesis of Polymyxin B (2-10) and Colistin (2-10) Analogs Employing the Trichloroethoxycarbonyl (Troc) Group for Side Chain Protection of [alpha],[gamma]-Diaminobutyric Acid Residues by Okimura, Keiko, Ohki, Kazuhiro, Sato, Yuki, Ohnishi, Kuniharu, Sakura, Naoki

“…Improved strategies for the chemical conversion of natural polymyxin B and colistin to their N-terminal analogs are reported. First, the protection of the side…”
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Contribution of each amino acid residue in polymyxin B(3) to antimicrobial and lipopolysaccharide binding activity by Kanazawa, Kazushi, Sato, Yuki, Ohki, Kazuhiro, Okimura, Keiko, Uchida, Yoshiki, Shindo, Mitsuno, Sakura, Naoki

“…This study on the structure-activity relationship of polymyxin B, a cyclic peptide antibiotic, used sixteen synthetic polymyxin B(3) analogs including alanine…”
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Synthesis of Neurokinin B Analogs and Their Activities as Agonists and Antagonists by HASHIMOTO, TADASHI, UCHIDA, YOSHIKI, OKIMURA, KEIKO, KUROSAWA, KATSURO

“…Nine neurokinin B (NKB) related octapeptide analogs, substituted with Arg for His3, or Gly, D-Trp, D-Ala or D-Phe for Phe6, or Gly for Val7, or D-Trp or D-Ala…”
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Agonistic and Antagonistic Activities of Neuromedin U-8 Analogs Substituted with Glycine or D-Amino Acid on Contractile Activity of Chicken Crop Smooth Muscle Preparations by HASHIMOTO, Tadashi, MASUI, Hiroko, UCHIDA, Yoshiki, SAKURA, Naoki, OKIMURA, Keiko

“…To study the structure-actibity relationships of neuromedin U-8 (NMU-8) (H-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2) and to develop a NMU-8 antagonist, twenty-three…”
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