Anti-Hyperglycemic and Anti-Inflammatory Activities of Polyphenolic-Rich Extract of Linn Leaves in Alloxan-Induced Diabetic Rats

Anti-Hyperglycemic and Anti-Inflammatory Activities of Polyphenolic-Rich Extract of Linn Leaves in Alloxan-Induced Diabetic Rats

In this study, anti-hyperglycemic and anti-inflammatory activities of polyphenolic-rich extract of Syzygium cumini leaves in alloxan-induced diabetic rats were determined. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg body weight) in female Wistar rats. The rats we...

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Bibliographic Details
Published in:Journal of evidence-based integrative medicine Vol. 23
Main Authors: Basiru O. Ajiboye PhD, Oluwafemi A. Ojo MSc, Olivia S. Akuboh BSc, Okesola M. Abiola MSc, Olajumoke Idowu MSc, Aliyu O. Amuzat MSc
Format: Journal Article
Language:English
Published: SAGE Publishing 01-05-2018
Online Access:Get full text
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Summary:In this study, anti-hyperglycemic and anti-inflammatory activities of polyphenolic-rich extract of Syzygium cumini leaves in alloxan-induced diabetic rats were determined. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg body weight) in female Wistar rats. The rats were orally administered with 400 mg/kg free phenol, 400 mg/kg bound phenol, and 5 mg/kg metformin, respectively. On the 14th day of oral administration, the animals were sacrificed, anti-hyperglycemic and anti-inflammatory were assessed. Fasting blood glucose and glycated hemoglobin levels; homeostasis model assessment–insulin resistance scores, lipid peroxidation concentration, glucose-6-phosphatase activity, and all concentrations of anti-inflammatory studied in alloxan-induced diabetic rats were significantly ( P < .05) reduced with the administration of polyphenolic-rich extract of Syzygium cumini leaves. Also there was significant ( P < .05) increase in glycogen and insulin concentrations, pancreatic β-cell scores, antioxidant enzymes and hexokinase activities, as well as glucose transporter levels in diabetic animals administered with polyphenolic-rich extract of S cumini leaves. The results indicate that S cumini leaves possess anti-hyperglycemic and anti-inflammatory activities.
ISSN:2515-690X
DOI:10.1177/2515690X18770630