Search Results - "Okerholm, R A"

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation by Yun, C H, Okerholm, R A, Guengerich, F P

“…The antihistaminic drug terfenadine, alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1- piperidinebutanol (Seldane), is of interest because of…”
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The Pharmacokinetics of Sodium Oxybate Oral Solution following Acute and Chronic Administration to Narcoleptic Patients by Borgen, Lowell A., Okerholm, Richard A., Lai, Allen, Scharf, Martin B.

“…This trial was conducted to evaluate the pharmacokinetics and safety of a sodium oxybate (gamma‐hydroxybutyrate [GHB]) oral solution in narcoleptic patients…”
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Determination of the metabolites of terfenadine in human urine by thermospray liquid chromatography-mass spectrometry by Chen, T M, Chan, K Y, Coutant, J E, Okerholm, R A

“…Thermospray liquid chromatography-mass spectrometry (TSP LC-MS) was used to determine human urinary metabolites of terfenadine after oral administration of…”
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Determination of MDL 73,005 in human plasma by solid-phase extraction and high-performance liquid chromatography by Chan, K Y, Satonin, D K, Cheng, L K, Okerholm, R A

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Pharmacokinetics of vigabatrin following single and multiple oral doses in normal volunteers by Hoke, J F, Yuh, L, Antony, K K, Okerholm, R A, Elberfeld, J M, Sussman, N M

“…The pharmacokinetics of vigabatrin were investigated after single and multiple oral doses in two groups of 24 healthy male volunteers. Vigabatrin was well…”
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Clinical pharmacology of intravenous enoximone: pharmacodynamics and pharmacokinetics in patients with heart failure by Smith, N A, Kates, R E, Lebsack, C, Ruder, M A, Mead, R H, Bekele, T, Okerholm, R A, Rubin, G M, Winkle, R A

“…Twenty-one patients with heart failure (New York Heart Association [NYHA] class II to IV) received a 24-hour infusion of enoximone followed by a 12-hour…”
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Pharmacology and pharmacokinetics of enoximone by Dage, R C, Okerholm, R A

“…Enoximone is an inotropic vasodilating agent. Its principal effects are positive inotropism and vasodilation, which are not accompanied by changes in…”
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Pharmacokinetics of terfenadine in healthy elderly subjects by Eller, M G, Walker, B J, Westmark, P A, Ruberg, S J, Antony, K K, McNutt, B E, Okerholm, R A

“…The pharmacokinetics of the terfenadine active metabolite, metabolite I, was examined in ten healthy elderly adults and ten younger adults after single-dose…”
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Quantitative analysis of vigabatrin in plasma and urine by reversed-phase high-performance liquid chromatography by Smithers, J A, Lang, J F, Okerholm, R A

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Bioavailability of terfenadine in man by Okerholm, R A, Weiner, D L, Hook, R H, Walker, B J, Leeson, G A, Biedenbach, S A, Cawein, M J, Dusebout, T D, Wright, G J, Myers, M, Schindler, V, Cook, C E

“…Fourteen normal male subjects were given either 60mg or 180mg of terfenadine suspension in a randomized two-way crossover study. Peak plasma concentrations of…”
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Acute hemodynamic effect of oral MDL 17,043 in severe congestive heart failure by Uretsky, Barry F., Generalovich, Thomas, Reddy, P.S., Salerni, Rosemarie, Valdes, Anita M., Spangenberg, Robert B., Lang, James F., Okerholm, Richard A.

“…MDL 17,043, when administered intravenously in humans, produces a significant and salutary hemodynamic response. To determine its acute effect when…”
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Absence of food effects on the pharmacokinetics of terfenadine by Eller, M G, Walker, B J, Yuh, L, Antony, K K, McNutt, B E, Okerholm, R A

“…Administration of terfenadine (Seldane) immediately after a high fat breakfast slightly affects the rate but not the extent of absorption relative to fasting…”
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Human serum and plasma protein binding of enoximone and its sulfoxide metabolite by Hook, R H, Boxenbaum, H, Thompson, G A, Okerholm, R A

“…Experimental factors and determinants of the protein binding of enoximone (a new cardiotonic agent) were investigated in human serum from healthy, drug-free…”
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Comparison of the pharmacokinetics of two nicotine transdermal systems: nicoderm and habitrol by Gupta, S K, Okerholm, R A, Eller, M, Wei, G, Rolf, C N, Gorsline, J

“…This randomized, crossover study compared the nicotine and cotinine pharmacokinetic parameters and plasma concentration profiles of two different nicotine…”
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Method of analysis of the new cardiotonic agent, MDL 19,205, in plasma and urine and its application in a dog pharmacokinetic study by Keeley, F J, Theile, J D, Garteiz, D A, Weiner, D L, Okerholm, R A

“…A high-performance liquid chromatographic method has been developed for the analysis of plasma and urine concentrations of a new cardiotonic agent, MDL 19,205…”
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Quantitative analysis of melperone in human plasma by gas chromatography--mass spectrometry--selected ion monitoring by Chan, K Y, Okerholm, R A

“…A sensitive, specific and reliable assay utilizing a combined gas chromatography--mass spectrometry--selected ion monitoring technique is described for the…”
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Single- and multiple-dose pharmacokinetics of Nicoderm (Nicotine Transdermal System) by Gupta, S K, Okerholm, R A, Coen, P, Prather, R D, Gorsline, J

“…The pharmacokinetics and tolerability of single and multiple applications of Nicotine Transdermal Systems (NTS), designed to deliver 14 mg of nicotine per 24…”
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Radioimmunoassay for terfenadine in human plasma by Cook, C E, Williams, D L, Myers, M, Tallent, C R, Leeson, G A, Okerholm, R A, Wright, G J

“…A radioimmunoassay procedure was developed for the antihistamine terfenadine…”
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The metabolism of gemfibrozil by Okerholm, R A, Keeley, F J, Peterson, F E, Glazko, A J

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Determination of terfenadine and terfenadine acid metabolite in plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection by Coutant, J E, Westmark, P A, Nardella, P A, Walter, S M, Okerholm, R A

“…This work describes the methodology for the analysis of terfenadine and the acid metabolite of terfenadine in plasma using high-performance liquid…”
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