Search Results - "Okello, Aren"

An early and late peak in microglial activation in Alzheimer's disease trajectory by Fan, Zhen, Brooks, David J, Okello, Aren, Edison, Paul

“…Amyloid-β deposition, neuroinflammation and tau tangle formation all play a significant role in Alzheimer's disease. We hypothesized that there is microglial…”
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Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer's disease by Fan, Zhen, Okello, Aren A, Brooks, David J, Edison, Paul

“…Amyloid deposition, tangle formation, neuroinflammation and neuronal dysfunction are pathological processes involved in Alzheimer's disease. However, the…”
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Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers by KNIGHT, William D, OKELLO, Aren A, RYAN, Natalie S, TURKHEIMER, Federico E, RODRIGUEZ MARTINEZ DE LLANO, Sofia, EDISON, Paul, DOUGLAS, Jane, FOX, Nick C, BROOKS, David J, ROSSOR, Martin N

“…(11)Carbon-Pittsburgh compound B positron emission tomography studies have suggested early and prominent amyloid deposition in the striatum in presenilin 1…”
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A European multicentre PET study of fibrillar amyloid in Alzheimer’s disease by Nordberg, Agneta, Carter, Stephen F., Rinne, Juha, Drzezga, Alexander, Brooks, David J., Vandenberghe, Rik, Perani, Daniela, Forsberg, Anton, Långström, Bengt, Scheinin, Noora, Karrasch, Mira, Någren, Kjell, Grimmer, Timo, Miederer, Isabelle, Edison, Paul, Okello, Aren, Van Laere, Koen, Nelissen, Natalie, Vandenbulcke, Mathieu, Garibotto, Valentina, Almkvist, Ove, Kalbe, Elke, Hinz, Rainer, Herholz, Karl

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A European multicentre PET study of fibrillar amyloid in Alzheimer’s disease by Nordberg, Agneta, Carter, Stephen F., Rinne, Juha, Drzezga, Alexander, Brooks, David J., Vandenberghe, Rik, Perani, Daniela, Forsberg, Anton, Långström, Bengt, Scheinin, Noora, Karrasch, Mira, Någren, Kjell, Grimmer, Timo, Miederer, Isabelle, Edison, Paul, Okello, Aren, Van Laere, Koen, Nelissen, Natalie, Vandenbulcke, Mathieu, Garibotto, Valentina, Almkvist, Ove, Kalbe, Elke, Hinz, Rainer, Herholz, Karl

“…Purpose Amyloid PET tracers have been developed for in vivo detection of brain fibrillar amyloid deposition in Alzheimer’s disease (AD). To serve as an early…”
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P1‐283: An Early and Late Peak in Microglial Activation in Alzheimer’s Disease Trajectory: A Longitudinal Pet Study by Fan, Zhen, Brooks, David J., Okello, Aren, Edison, Paul

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ANALYSIS OF AN ADULT DUCHENNE MUSCULAR DYSTROPHY POPULATION: TEN YEARS ON by Wu, Kit, Rigaudy, Axelle, Christodoulou, Loucas, Okello, Aren, Ballard, Emily, Hart, Nicholas, Howard, Robin

“…BackgroundDuchenne muscular dystrophy (DMD) is a progressive, multi-systemic condition, management of which has benefitted from improvements in research and…”
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AN EARLY AND LATE PEAK IN MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE TRAJECTORY: A LONGITUDINAL PET STUDY by Fan, Zhen, Brooks, David J, Okello, Aren, Edison, Paul

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11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study by Rinne, Juha O, Brooks, David J, Rossor, Martin N, Fox, Nick C, Bullock, Roger, Klunk, William E, Mathis, Chester A, Blennow, Kaj, Barakos, Jerome, Okello, Aren A, de LIano, Sofia Rodriguez Martinez, Liu, Enchi, Koller, Martin, Gregg, Keith M, Schenk, Dale, Black, Ronald, Grundman, Michael

“…Carbon-11-labelled Pittsburgh compound B ( 11C-PiB) PET is a marker of cortical fibrillar amyloid-β load in vivo. We used 11C-PiB PET to investigate whether…”
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sup 11^C-PiB PET assessment of change in fibrillar amyloid-[beta] load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study by Rinne, Juha O, Brooks, David J, Rossor, Martin N, Fox, Nick C, Bullock, Roger, Klunk, William E, Mathis, Chester A, Blennow, Kaj, Barakos, Jerome, Okello, Aren A, de LIano, Sofia Rodriguez Martinez, Liu, Enchi, Koller, Martin, Gregg, Keith M, Schenk, Dale, Black, Ronald, Grundman, Michael

“…Carbon-11-labelled Pittsburgh compound B ((11)C-PiB) PET is a marker of cortical fibrillar amyloid-beta load in vivo. We used (11)C-PiB PET to investigate…”
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super(11)C-PiB PET assessment of change in fibrillar amyloid- beta load in patients with Alzheimer' s disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study by Rinne, Juha O, Brooks, David J, Rossor, Martin N, Fox, Nick C, Bullocksych, Roger, Klunk, William E, Mathis, Chester A, Blennow, Kaj, Barakos, Jerome, Okello, Aren A, De LIano, Sofia Rodriguez Martinez, Liu, Enchi, Koller, Martin, Gregg, Keith M, Schenk, Dale, Black, Ronald, Grundman, Michael

“…Carbon-11-labelled Pittsburgh compound B ( super(11)C-PiB) PET is a marker of cortical fibrillar amyloid- beta load in vivo. We used super(11)C-PiB PET to…”
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O3‐06‐03: Early subcortical amyloid deposition in familial Alzheimer's disease is accompanied by changes in tissue volume and diffusivity by Ryan, Natalie S., Okello, Aren, Knight, William D., Lehmann, Manja, Malone, Ian, Clarkson, Matthew J., Bartlett, Jonathan, Ridgway, Gerard R., Mancini, Laura, Thornton, John, Ourselin, Sebastian, Brooks, David J., Rossor, Martin N., Fox, Nick C.

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11 C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study by Rinne, Juha O, MD, Brooks, David J, MD, Rossor, Martin N, FRCP, Fox, Nick C, FRCP, Bullock, Roger, MRCPsych, Klunk, William E, MD, Mathis, Chester A, PhD, Blennow, Kaj, MD, Barakos, Jerome, MD, Okello, Aren A, MRCP, de LIano, Sofia Rodriguez Martinez, MD, Liu, Enchi, PhD, Koller, Martin, MD, Gregg, Keith M, PhD, Schenk, Dale, PhD, Black, Ronald, MD, Grundman, Michael, MD

“…Summary Background Carbon-11-labelled Pittsburgh compound B (11 C-PiB) PET is a marker of cortical fibrillar amyloid-β load in vivo. We used11 C-PiB PET to…”
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Pet studies on disease progression and treatment efficacy in alzheimer's disease and mild cognitive impairment by Okello, Aren Atiti

“…Alzheimer’s disease (AD) is the most common cause of dementia. Mild cognitive impairment (MCI) is a transitional state between normal ageing and dementia…”
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Early subcortical amyloid deposition in familial Alzheimer's disease is accompanied by changes in tissue volume and diffusivity by Ryan, Natalie S, Okello, Aren, Knight, William D, Lehmann, Manja, Malone, Ian, Clarkson, Matthew J, Bartlett, Jonathan, Ridgway, Gerard R, Mancini, Laura, Thornton, John, Ourselin, Sebastian, Brooks, David J, Rossor, Martin N, Fox, Nick C

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IC‐S1‐03: PET Amyloid imaging and cognition in patients with Alzheimer's disease, Mild Cognitive Impairment (MCI) and healthy controls: a European multicenter study by Nordberg, Agneta, Rinne, Juha, Drzezga, Alexander, Brooks, David J., Vandenberghe, Rik, Perani, Daniela, Almkvist, Ove, Scheinin, Noora, Grimmer, Timo, Okello, Aren, Van Laere, Koen, Hinz, Rainer, Carter, Stephen F., Kalbe, Elke, Herholz, Karl

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PET Amyloid imaging and cognition in patients with Alzheimer's disease, Mild Cognitive Impairment (MCI) and healthy controls: a European multicenter study by Nordberg, Agneta, Rinne, Juha, Drzezga, Alexander, Brooks, David J, Vandenberghe, Rik, Perani, Daniela, Almkvist, Ove, Scheinin, Noora, Grimmer, Timo, Okello, Aren, Van Laere, Koen, Hinz, Rainer, Carter, Stephen F, Kalbe, Elke, Herholz, Karl

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O3-06-05: Amyloid deposition and cerebral glucose metabolism in Alzheimer’s disease: A longitudinal 11C-PIB and 18F-FDG PET study by Edison, Paul, Okello, Aren, Archer, Hilary, Hinz, Rainer, Fox, Nick, Rossor, Martin, Brooks, David J.

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O3–06–05: Amyloid deposition and cerebral glucose metabolism in Alzheimer's disease: A longitudinal 11 C–PIB and 18 F–FDG PET study by Edison, Paul, Okello, Aren, Archer, Hilary, Hinz, Rainer, Fox, Nick, Rossor, Martin, Brooks, David J.

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P2–120: Amyloid deposition and cerebral glucose metabolism in mild cognitive impairment : A longitudinal 11 C–PIB and 18 F–FDG PET study by Okello, Aren, Edison, Paul, Archer, Hilary, Hinz, Rainer, Fox, Nick, Rossor, Martin, Brooks, David

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