Search Results - "Okayasu, R"

Radiosensitization Effect of PARP Inhibitor in Cells Exposed to Low and High LET Radiation by Hirai, T, Shirai, H, Okayasu, R, Sasai, K, Masutani, M

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1053 poster EFFECTS OF CARBON ION BEAM ON PUTATIVE COLON CANCER STEM CELLS AND ITS CORRELATION WITH RADIOCURABILITY by Sai, S, Oonishi, K, Yamada, S, Kamada, T, Okayasu, R

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Single extreme low dose low dose rate irradiation causes alteration in lifespan and genome instability in primary human cells by OKADA, M, OKABE, A, UCHIHORI, Y, KITAMURA, H, SEKINE, E, EBISAWA, S, SUZUKI, M, OKAYASU, R

“…To investigate the long-term biological effect of extreme low dose ionising radiation, we irradiated normal human fibroblasts (HFLIII) with carbon ions (290…”
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Relative biological effects of neutron mixed-beam irradiation for boron neutron capture therapy on cell survival and DNA double-strand breaks in cultured mammalian cells by Okumura, Kakuji, Kinashi, Yuko, Kubota, Yoshihisa, Kitajima, Erika, Okayasu, Ryuichi, Ono, Koji, Takahashi, Sentaro

“…Understanding the biological effects of neutron mixed-beam irradiation used for boron neutron capture therapy (BNCT) is important in order to improve the…”
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Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene by Yu, Y., Okayasu, R., Weil, M. M., Silver, A., McCarthy, M., Zabriskie, R., Long, S., Cox, R., Ullrich, R. L.

“…Female BALB/c mice are unusually radiosensitive and more susceptible than C57BL/6 and other tested inbred mice to ionizing radiation (IR)-induced mammary…”
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A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse by Okayasu, R., Suetomi, K., Yu, Y., Silver, A., Bedford, J. S., Cox, R., Ullrich, R. L.

“…We have studied the efficiency of DNA double strand break (DSB) rejoining in primary cells from mouse strains that show large differences in in vivo…”
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Overview and Initial Results of the Very Long Baseline Interferometry Space Observatory Programme by Hirabayashi, H., Hirosawa, H., Kobayashi, H., Murata, Y., Edwards, P. G., Fomalont, E. B., Fujisawa, K., Ichikawa, T., Kii, T., Lovell, J. E. J., Moellenbrock, G. A., Okayasu, R., Inoue, M., Kawaguchi, N., Kameno, S., Shibata, K. M., Asaki, Y., Bushimata, T., Enome, S., Horiuchi, S., Miyaji, T., Umemoto, T., Migenes, V., Wajima, K., Nakajima, J., Morimoto, M., Ellis, J., Meier, D. L., Murphy, D. W., Preston, R. A., Smith, J. G., Tingay, S. J., Traub, D. L., Wietfeldt, R. D., Benson, J. M., Claussen, M. J., Flatters, C., Romney, J. D., Ulvestad, J. S., D'Addario, L. R., Langston, G. I., Minter, A. H., Carlson, B. R., Dewdney, P. E., Jauncey, D. L., Reynolds, J. E., Taylor, A. R., McCulloch, P. M., Cannon, W. H., Gurvits, L. I., Mioduszewski, A. J., Schilizzi, R. T., Booth, R. S.

“…High angular resolution images of extragalactic radio sources are being made with the Highly Advanced Laboratory for Communications and Astronomy (HALCA)…”
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Induction of DNA DSB and its rejoining in clamped and non-clamped tumours after exposure to carbon ion beams in comparison to X rays by Hirayama, R, Uzawa, A, Matsumoto, Y, Noguchi, M, Kase, Y, Takase, N, Ito, A, Koike, S, Ando, K, Okayasu, R, Furusawa, Y

“…We studied double-strand breaks (DSB) induction and rejoining in clamped and non-clamped transplanted tumours in mice leg after exposure to 80 keV µm(-1)…”
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Biological effects of naturally occurring and man-made fibres: in vitro cytotoxicity and mutagenesis in mammalian cells by OKAYASU, R, WU, L, HEI, T. K

“…Cytotoxicity and mutagenicity of tremolite, erionite and the man-made ceramic (RCF-1) fibre were studied using the human-hamster hybrid A(L) cells. Results…”
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Inhibition of Repair of Radiation-Induced DNA Double-Strand Breaks by Nickel and Arsenite by Takahashi, Sentaro, Takeda, Eriko, Kubota, Yoshihisa, Okayasu, Ryuichi

“…Takahashi, S., Takeda, E., Kubota, Y. and Okayasu, R. Inhibition of Repair of Radiation-Induced DNA Double-Strand Breaks by Nickel and Arsenite. The effect of…”
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Cellular signal transduction events as a function of linear energy transfer (LET) by Fürweger, C., Hajek, M., Vana, N., Kodym, R., Okayasu, R.

“…In order to obtain a deeper insight into the molecular mechanism controlling the cellular response to high-linear energy transfer (LET) radiation, the number…”
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The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes quiescent but not proliferating MG-63 human osteosarcoma cells to radiation by Kubota, N., Ozawa, F., Okada, S., Inada, T., Komatsu, K., Okayasu, R.

“…Recent genetic and biochemical studies indicate that DNA-dependent protein kinase (DNA-PK) plays an important role in DNA double-strand break (dsb) repair and…”
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Introduction to NIRS International Open Laboratory (IOL) by Okayasu, Ryuichi

“…Objectives of IOL: We have two primary objectives: (i) To conduct world premier research in radiation sciences by collaborating with distinguished scientists…”
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Ionizing Radiation Induces Two Forms of Interphase Chromosome Breaks in Chinese Hamster Ovary Cells That Rejoin with Different Kinetics and Show Different Sensitivity to Treatment in Hypertonic Medium or β-araA by Okayasu, Ryuichi, Iliakis, George

“…We have shown previously that incubation of irradiated plateau-phase CHO cells in hypertonic growth medium during the period normally allowed for chromosome…”
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Radiosensitivity throughout the cell cycle and repair of potentially lethal damage and DNA double-strand breaks in an X-ray-sensitive CHO mutant by Iliakis, G E, Okayasu, R

“…The response to ionizing radiation of synchronized and plateau-phase populations of xrs-5 cells was studied at the DNA and cellular level. Induction and repair…”
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Mechanism of Radiosensitization by Halogenated Pyrimidines: Effect of BrdU on Radiation Induction of DNA and Chromosome Damage and Its Correlation with Cell Killing by Iliakis, George, Kurtzman, Steven, Pantelias, Gabriel, Okayasu, Ryuichi

“…The effect of BrdU incorporation on cell radiosensitivity as well as on the induction of DNA double-strand breaks (DSB) and chromosome damage by radiation was…”
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Evidence That the Product of the xrs Gene Is Predominantly Involved in the Repair of a Subset of Radiation-Induced Interphase Chromosome Breaks Rejoining with Fast Kinetics by Okayasu, Ryuichi, Iliakis, George

“…We classified interphase chromosome breaks into α and β forms to study the requirement for the xrs gene product in the repair of each of these forms of damage…”
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Arsenic accumulation, elimination, and interaction with copper, zinc and manganese in liver and kidney of rats by Cui, Xing, Okayasu, Ryuichi

“…The arsenic accumulation, distribution and influences on metallothionein-1 (MT-1) expression and other trace elements in various organs were examined in rats…”
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Hypertonic Treatment Does Not Affect the Radiation Yield of Interphase Chromosome Breaks in DNA Double-Strand Break Repair-Deficient xrs-5 Cells by Okayasu, Ryuichi, Varlotto, John, Iliakis, George

“…A DNA double-strand break (DSB) repair-deficient CHO cell line, xrs-5, was used to evaluate the effect of hypertonic treatment on the radiation yield of…”
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In vitro rejoining of double-strand breaks in cellular DNA by factors present in extracts of HeLa cells by Cheong, N, Okayasu, R, Shah, S, Ganguly, T, Mammen, P, Iliakis, G

“…We described previously a cell-free assay, that could be employed to study the rejoining of radiation-induced DNA double-strand breaks (dsb) in agarose…”
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