TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility

COVID-19 has a wide range of clinical presentations, and the susceptibility to SARS-CoV-2 infection and the mortality rate also vary by region and ethnicity. Here, we found that rs12329760 in the gene, a missense variant common in East Asian populations, contributes to protection against SARS-CoV-2...

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Bibliographic Details
Published in:	Frontiers in microbiology Vol. 13; p. 943877
Main Authors:	Sekiya, Takeshi, Ogura, Yukino, Kai, Hirayasu, Kawaguchi, Atsushi, Okawa, Shino, Hirohama, Mikako, Kuroki, Takahiro, Morii, Wataru, Hara, Akira, Hiramatsu, Yuji, Hitomi, Shigemi, Kawakami, Yasushi, Arakawa, Yoshihiro, Maruo, Kazushi, Chiba, Shigeru, Suzuki, Hiromichi, Kojima, Hiroshi, Tachikawa, Hirokazu, Yamagata, Kunihiro
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 30-11-2022
Subjects:	COVID-19 Microbiology SARS-CoV-2 SNP tmprss2 virus entry COVID-19 virus entry SARS-CoV-2 SNP tmprss2
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Summary:	COVID-19 has a wide range of clinical presentations, and the susceptibility to SARS-CoV-2 infection and the mortality rate also vary by region and ethnicity. Here, we found that rs12329760 in the gene, a missense variant common in East Asian populations, contributes to protection against SARS-CoV-2 infection. TMPRSS2 is a protease responsible for SARS-CoV-2 entry and syncytium formation. rs12329760 (c.478G>A, p. V160M) was associated with a reduced risk of moderate symptoms. The enzymatic activity of Met -TMPRSS2 was lower than that of Val -TMPRSS2, and thus the viral entry and the syncytium formation of SARS-CoV-2 were impaired. Collectively, these results indicate that the genetic variation in , which is common in East Asians, is one of the molecular determinants of COVID-19 susceptibility.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Masako Nomaguchi, Tokushima University, Japan These authors have contributed equally to this work This article was submitted to Virology, a section of the journal Frontiers in Microbiology Reviewed by: Ludmila Prokunina-Olsson, National Institutes of Health, United States; Anand Bhushan, Cleveland Clinic, United States
ISSN:	1664-302X 1664-302X
DOI:	10.3389/fmicb.2022.943877