Search Results - "Okasinski, Gregory F."

Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties by Liu, Gang, Huth, Jeffrey R, Olejniczak, Edward T, Mendoza, Renaldo, DeVries, Peter, Leitza, Sandra, Reilly, Edward B, Okasinski, Gregory F, Fesik, Stephen W, von Geldern, Thomas W

“…The interaction between leukocyte function-associated antigen-1 (LFA-1) and intracellular adhesion molecule-1 (ICAM-1) has been implicated in inflammatory and…”
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Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 1. Identification of an Additional Binding Pocket Based on an Anilino Diaryl Sulfide Lead by Liu, Gang, Link, J. T, Pei, Zhonghua, Reilly, Edward B, Leitza, Sandra, Nguyen, Bach, Marsh, Kennan C, Okasinski, Gregory F, von Geldern, Thomas W, Ormes, Mark, Fowler, Kerry, Gallatin, Mike

“…The interaction between leukocyte function-associated antigen-1 (LFA-1), a member of the β2-integrin family of adhesion molecules, and intracellular adhesion…”
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Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 4. Structure−Activity Relationship of Substituents on the Benzene Ring of the Cinnamide by Winn, Martin, Reilly, Edward B, Liu, Gang, Huth, Jeffrey R, Jae, Hwan-Soo, Freeman, Jennifer, Pei, Zhonghua, Xin, Zhili, Lynch, John, Kester, Jeff, von Geldern, Thomas W, Leitza, Sandra, DeVries, Peter, Dickinson, Robert, Mussatto, Donna, Okasinski, Gregory F

“…We have shown that p-arylthio cinnamides can inhibit the interaction of LFA-1 and ICAM-1, which is involved in cell adhesion and the inflammatory process. We…”
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Selective Inhibition of ICAM-1 and E-Selectin Expression in Human Endothelial Cells. 2. Aryl Modifications of 4-(Aryloxy)thieno[2,3-c]pyridines with Fine-Tuning at C-2 Carbamides by Zhu, Gui-Dong, Arendsen, David L, Gunawardana, Indrani W, Boyd, Steven A, Stewart, Andrew O, Fry, Dennis G, Cool, Barbara L, Kifle, Lemma, Schaefer, Verlyn, Meuth, Joseph, Marsh, Kennan C, Kempf-Grote, Anita J, Kilgannon, Patrick, Gallatin, W. Michael, Okasinski, Gregory F

“…The elevated expression of cell adhesion molecules (CAMs) on the lumenal surface of vascular endothelial cells is a critical early event in the complex…”
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Synthesis and mode of action of (125)I- and (3)H-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression by Zhu, Gui-Dong, Schaefer, Verlyn, Boyd, Steven A, Okasinski, Gregory F

“…A series of thieno[2,3-c]pyridine antagonists of cell adhesion molecule (CAM) expression, such as A-205804 (1) and A-249377 (2), selectively suppressed the…”
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Synthesis and Mode of Action of 125I- and 3H-Labeled Thieno[2,3-c]pyridine Antagonists of Cell Adhesion Molecule Expression by Zhu, Gui-Dong, Schaefer, Verlyn, Boyd, Steven A., Okasinski, Gregory F.

“…A series of thieno[2,3-c]pyridine antagonists of cell adhesion molecule (CAM) expression, such as A-205804 (1) and A-249377 (2), selectively suppressed the…”
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A novel stimulus, oncogene, induces expression of CD80 (B7-1) gene by Zhang, H, Haasch, D, Patterson, B, Dickinson, B, Kifle, L, Fry, D G, Okasinski, G F

“…CD80, a cell surface molecule found on antigen-presenting cells which particpates in costimulatory signaling, is frequently detected on transformed and tumor…”
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Expression of CD80 promoter in transgenic mice by Zhang, Haiying, Haasch, Deanna, Patterson, Bob, Dickinson, Bob, Okasinski, Gregory F

“…CD80 is a very potent co-stimulatory factor which is required for complete T-cell activation. Here, we use transgenic mice as a tool to map the promoter of the…”
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Synthesis and Mode of Action of 125 I- and 3 H-Labeled Thieno[2,3- c ]pyridine Antagonists of Cell Adhesion Molecule Expression by Zhu, Gui-Dong, Schaefer, Verlyn, Boyd, Steven A., Okasinski, Gregory F.

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Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression by Stewart, Andrew O, Bhatia, Pramila A, McCarty, Catherine M, Patel, Meena V, Staeger, Michael A, Arendsen, David L, Gunawardana, Indrani W, Melcher, Laura M, Zhu, Gui-Dong, Boyd, Steven A, Fry, Dennis G, Cool, Barbara L, Kifle, Lemma, Lartey, Kraig, Marsh, Kennan C, Kempf-Grote, Anita J, Kilgannon, Patrick, Wisdom, Wendy, Meyer, Joey, Gallatin, W. Michael, Okasinski, Gregory F

“…A critical early event in the inflammatory cascade is the induced expression of cell adhesion molecules on the lumenal surface of vascular endothelial cells…”
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Expression, Purification, and Characterization of Human Recombinant Thrombopoietin in Chinese Hamster Ovary Cells by Kaszubska, Wiweka, Zhang, Haiying, Patterson, Robert L., Suhar, Thomas S., Uchic, Marie E., Dickinson, Robert W., Schaefer, Verlyn G., Haasch, Deanna, Janis, Richard S., DeVries, Peter J., Okasinski, Gregory F., Meuth, Joseph L.

“…Thrombopoietin (TPO) is a primary regulator of megakaryocytopoiesis, a process through which megakaryocytes proliferate and mature into platelets. Recombinant…”
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Isolation and promoter mapping of the gene encoding murine co-stimulatory factor B7-1 by Zhang, Haiying, Haasch, Deanna, Idler, Kenneth B., Okasinski, Gregory F.

“…B7-1 is one of the co-stimulatory factors which plays an important role in immunity. We have cloned and functionally mapped the promoter of the murine B7-1…”
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