Search Results - "Okasha, Rawda M."
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Successful Green Synthesis of Gold Nanoparticles using a Corchorus olitorius Extract and Their Antiproliferative Effect in Cancer Cells
Published in International journal of molecular sciences (03-09-2018)“…A facile bottom-up "green" synthetic route of gold nanoparticles (Au NPs) is described, using a leaf extract of the plant as a reducing and stabilizing agent…”
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A New Family of Benzo[ h ]Chromene Based Azo Dye: Synthesis, In-Silico and DFT Studies with In Vitro Antimicrobial and Antiproliferative Assessment
Published in International journal of molecular sciences (10-03-2021)“…The high biological activity of the chromene compounds coupled with the intriguing optical features of azo chromophores prompted our desire to construct novel…”
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Synthesis and Characterization of a New Class of Chromene-Azo Sulfonamide Hybrids as Promising Anticancer Candidates with the Exploration of Their EGFR, hCAII, and MMP-2 Inhibitors Based on Molecular Docking Assays
Published in International journal of molecular sciences (01-12-2023)“…In this study, novel selective antitumor compounds were synthesized based on their fundamental pharmacophoric prerequisites associated with EGFR inhibitors. A…”
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DFT and In-silico Investigations, along with In-vitro Antitumor and Antimicrobial Assessments of Pharmacological Molecules
Published in Current organic synthesis (01-01-2023)“…Molecules bearing an active methylene bridge are one of the most fruitful and remarkable precursors that have been incorporated into the synthetic strategy of…”
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Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels
Published in Journal of enzyme inhibition and medicinal chemistry (01-12-2023)“…A series of 1H-benzo[f]chromene moieties (4a-z) were synthesised under Ultrasonic irradiation and confirmed with spectral analyses. Derivative 4i solely…”
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Synthesis, Biological Assessment, and Structure Activity Relationship Studies of New Flavanones Embodying Chromene Moieties
Published in Molecules (Basel, Switzerland) (27-01-2020)“…Novel flavanones that incorporate chromene motifs are synthesized via a one-step multicomponent reaction. The structures of the new chromenes are elucidated by…”
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Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions
Published in Molecules (Basel, Switzerland) (18-03-2017)“…A series of novel 4 -benzo[ ]chromenes , - , , ; 7 -benzo[ ]chromeno[2,3- ]pyrimidines - , , and 14 -benzo[ ]chromeno[3,2- ][1,2,4]triazolo[1,5- ]pyrimidine…”
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Design and Synthesis of Novel Heterocyclic-Based 4H-benzo[h]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis
Published in Molecules (Basel, Switzerland) (18-03-2019)“…Novel fused chromenes (4,7–11) and pyrimidines (12–16) were designed, synthesized, and evaluated for their mammary gland breast cancer (MCF-7), human colon…”
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Design of Novel Oligomeric Mixed Ligand Complexes: Preparation, Biological Applications and the First Example of Their Nanosized Scale
Published in International journal of molecular sciences (10-02-2019)“…A successful oligomerization of ternary metal complexes, cobalt (II), nickel (II), copper (II), zinc (II), chromium (III) and ferric sulfate (III) with…”
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Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect
Published in Journal of enzyme inhibition and medicinal chemistry (01-01-2018)“…In our effort to develop novel and powerful agents with anti-proliferative activity, two new series of 1H-benzo[f]chromene derivatives, 4a-h and 6a-h, were…”
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Structural Characterization and Antimicrobial Activities of 7H-Benzo[h]chromeno[2,3-d]pyrimidine and 14H-Benzo[h]chromeno[3,2-e][1,2,4]triazolo[1,5-c] pyrimidine Derivatives
Published in Molecules (Basel, Switzerland) (01-11-2016)“…Three new series of chromene molecules have been synthesized in order to explore their antimicrobial activity. The series encompass 2-substituted…”
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Cationic Cyclopentadienyliron Complex as a Novel and Successful Nucleating Agent on the Crystallization Behavior of the Biodegradable PHB Polymer
Published in Molecules (Basel, Switzerland) (19-10-2018)“…Cationic cyclopentadienyliron (CpFe⁺) is one of the most fruitful organometallic moieties that has been utilized to mediate the facile synthesis of a massive…”
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Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors
Published in International journal of molecular sciences (08-11-2019)“…Protein kinases orchestrate diverse cellular functions; however, their dysregulation is linked to metabolic dysfunctions, associated with many diseases,…”
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Novel 2-Hydroselenonicotinonitriles and Selenopheno[2, 3-b]pyridines: Efficient Synthesis, Molecular Docking-DFT Modeling, and Antimicrobial Assessment
Published in Frontiers in chemistry (10-05-2021)“…Selenium containing heterocyclic compounds gained great interest as bioactive molecules as of late. This report explores the design, synthesis,…”
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Synthesis, Cytotoxic Activity, Crystal Structure, DFT, Molecular Docking Study of β-Enaminonitrile Incorporating 1H-Benzo[f]Chromene Moiety
Published in Crystals (Basel) (01-01-2023)“…In this work, we used microwave irradiation conditions to synthesize β-enaminonitrile (4), which was affirmed using single crystal X-ray diffraction and the…”
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The Crystal Structure of 3-Amino-1-(4-Chlorophenyl)-9-Methoxy-1H-Benzo[f]Chromene-2-Carbonitrile: Antimicrobial Activity and Docking Studies
Published in Crystals (Basel) (01-07-2022)“…Compound 3-amino-1-(4-chlorophenyl)-9-methoxy-1H-benzo[f]chromene-2-carbonitrile (4), was synthesized via the reaction of 7-methoxynaphthalen-2-ol (1),…”
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The Crystal Structure of 2-Amino-4-(2,3-Dichlorophenyl)-6-Methoxy-4H-Benzo[h]chromene-3-Carbonitrile: Antitumor and Tyrosine Kinase Receptor Inhibition Mechanism Studies
Published in Crystals (Basel) (01-05-2022)“…The target compound, 2-amino-4-(2,3-dichlorophenyl)-6-methoxy-4H-benzo[h]chromene -3-carbonitrile (4), was synthesized via the reaction of…”
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Catalytic Activity of Sulfated and Phosphated Catalysts towards the Synthesis of Substituted Coumarin
Published in Catalysts (01-01-2018)“…New modified acidic catalysts were prepared from the treatment of silica, titania and silica prepared from hydrolyzed tetraethyl orthosilicate (TEOS) with…”
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Design of Thermochromic Polynorbornene Bearing Spiropyran Chromophore Moieties: Synthesis, Thermal Behavior and Dielectric Barrier Discharge Plasma Treatment
Published in Polymers (22-11-2017)“…A new class of thermochromic polynorbornene with pendent spiropyran moieties has been synthesized. Functionalization of norbornene monomers with…”
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Effect of dopant on the conductivity and stability of three different cotton fabrics impregnated with PEDOT:PSS
Published in Cellulose (London) (2020)“…This study has investigated the electrical conductivity (sheet resistance) and morphological properties of dental cotton, textile cotton and gauze cotton after…”
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