Search Results - "Okamura, W."

1alpha,25-Dihydroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action by Shi, H, Norman, A W, Okamura, W H, Sen, A, Zemel, M B

“…We reported recently that suppression of the renal 1alpha,25-dihyroxyvitamin D3 (1lpha,25-(OH)2-D3) production in aP2-agouti transgenic mice by increasing…”
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Structure-function relationships in the vitamin D endocrine system by Bouillon, R, Okamura, W H, Norman, A W

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Identification of a specific binding protein for 1 alpha,25-dihydroxyvitamin D3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachia by Nemere, I, Dormanen, M C, Hammond, M W, Okamura, W H, Norman, A W

“…The steroid hormone 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3) elicits biological responses by both genomic and nongenomic pathways. This report…”
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Demonstration that 1 beta, 25-dihydroxyvitamin D3 is an antagonist of the nongenomic but not genomic biological responses and biological profile of the three A-ring diastereomers of 1 alpha, 25-dihydroxyvitamin D3 by Norman, A.W, Bouillon, R, Farach-Carson, M.C, Bishop, J.E, Zhou, L.X, Nemere, I, Zhao, J, Muralidharan, K.R, Okamura, W.H

“…The steroid hormone 1alpha,25-dihydroxyvitamin D3 (1alpha,25-(OH)2D3) generates biological responses via both genomic and nongenomic mechanisms. This article…”
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Structure-function studies of 1,25-dihydroxyvitamin D3 and the vitamin D endocrine system. 1,25-dihydroxy-pentadeuterio-previtamin D3 (as a 6-s-cis analog) stimulates nongenomic but not genomic biological responses by NORMAN, A. W, OKAMURA, W. H, FARACH-CARSON, M. C, ALLEWAERT, K, BRANISTEANU, D, NEMERE, I, MURALIDHARAN, K. R, BOUILLON, R

“…The hormone 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) generates biological responses via both genomic and nongenomic mechanisms. This article addresses activity…”
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Ultrahigh-efficiency power amplifier for space radar applications by Quach, T.K., Watson, P.M., Okamura, W., Kaneshiro, E.N., Gutierrez-Aitken, A., Block, T.R., Eldredge, J.W., Jenkins, T.J., Kehias, L.T., Oki, A.K., Sawdai, D., Welch, R.J., Worley, R.D.

“…This paper describes a broad-band switch mode power amplifier based on the indium phosphide (InP) double heterojunction bipolar transistor (DHBT) technology…”
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Profile of ligand specificity of the vitamin D binding protein for 1α,25‐dihydroxyvitamin d3 and its analogs by Bishop, June E., Collins, Elaine D., Okamura, William H., Norman, Anthony W.

“…The profile of structural preference for the ligand binding domain of the human vitamin D binding protein (DBP) was determined by steroid competition assay of…”
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Ligands for the vitamin D endocrine system: different shapes function as agonists and antagonists for genomic and rapid response receptors or as a ligand for the plasma vitamin D binding protein by Norman, Anthony W., Ishizuka, Seiichi, Okamura, William H.

“…The integrated operation of the vitamin D endocrine system which produces the steroid hormone 1α,25(OH) 2-vitamin D 3 (1α,25(OH) 2D 3) is dependent on four…”
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Production of 1α, 25-dihydroxy-3-epi-vitamin D3 in two rat osteosarcoma cell lines (UMR 106 and ROS 17/2.8) : Existence of the C-3 epimerization pathway in ROS 17/2.8 cells in which the C-24 oxidation pathway is not expressed by SIU-CALDERA, M.-L, SEKIMOTO, H, REDDY, G. S, WEISKOPF, A, VOUROS, P, MURALIDHARAN, K. R, OKAMURA, W. H, BISHOP, J, NORMAN, A. W, USKOKOVIC, M. R, SCHUSTER, I

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Chemistry and conformation of vitamin D molecules by Okamura, William H., Midland, M.Mark, Hammond, Marion W., Abd.Rahman, Noorsaadah, Dormanen, Murray C., Nemere, Ilka, Norman, Anthony W.

“…1α,25-Dihydroxyvitamin D 3 (1,25) is a structurally unique steroid hormone because it not only possesses the complete 25-hydroxycholesterol side chain, but…”
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Development of a Novel 1,25 (OH)2-Vitamin D3 Analog With Potent Ability to Induce HL-60 Cell Differentiation Without Modulating Calcium Metabolism by Zhou, Jian-Yuan, Norman, Anthony W., Akashi, Makoto, Chen, Dan-Lin, Uskokovic, Milan R., Aurrecoechea, J.M., Dauben, William G., Okamura, William H., Koeffler, H.Phillip

“…We describe several novel analogs of the seco-steroid 1,25(OH)2-vitamin D3[1,25(OH)2D3] and their effects on differentiation and proliferation of HL-60 human…”
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Vitamin D: structure-function analyses and the design of analogs by Okamura, W H, Palenzuela, J A, Plumet, J, Midland, M M

“…There is continuing and emerging new interest in the development of vitamin D analogs resulting from the recognition that analogs of 1…”
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Highest efficiency, linear X-band performance using InP DHBTs - 48% PAE at 30 dB C/IM3 by Kehias, L., Jenkins, T., Quach, T., Watson, P., Welch, R., Worley, R., Oki, A.K., Yen, H.C., Gutierrez-Aitken, A., Okamura, W., Kaneshiro, E.

“…InP single heterojunction bipolar transistors have previously demonstrated 5-10 dB lower third-order intermodulation products (IM3) compared to GaAs…”
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14-epi stereoisomers of 25-hydroxy- and 1α,25-dihydroxyvitamin D3 : synthesis, isomerization to previtamins, and biological studies by MAYNARD, D. F, TRANKLE, W. G, NORMAN, A. W, OKAMURA, W. H

“…The C-14 epimers of vitamin D, 14-epi-25-hydroxyvitamin D3 (4) and 14-epi-1 alpha, 25-dihydroxyvitamin D3 (5), were synthesized, and their isomerization via…”
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Ligand structure-function relationships in the vitamin D endocrine system from the perspective of drug development (including cancer treatment) by Norman, Anthony W, Mizwicki, Mathew T, Okamura, William H

“…It has become readily apparent to many scientists and pharmaceutical companies that the vitamin D endocrine system offers a wide array of drug development…”
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Selective biological response by target organs (intestine, kidney, and bone) to 1,25-dihydroxyvitamin D3 and two analogues by NORMAN, A. W, SERGEEV, I. N, BISHOP, J. E, OKAMURA, W. H

“…The hormonally active form of vitamin D, 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] stimulates biological responses related to calcium homeostasis,…”
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1 beta, 25 (OH)2-vitamin D3 is an antagonist of 1 alpha,25 (OH)2-vitamin D3 stimulated transcaltachia (the rapid hormonal stimulation of intestinal calcium transport) by Norman, A W, Nemere, I, Muralidharan, K R, Okamura, W H

“…The steroid hormone 1 alpha,25-dihydroxyvitamin-D3 [1 alpha,25(OH)2D3] stimulates biological responses via both genomic mechanisms and nongenomic mechanisms…”
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Ultra-efficient X-band and linear-efficient Ka-band power amplifiers using indium phosphide double heterojunction bipolar transistors by Quach, T., Okamura, W., Gutierrez-Aitken, A., Jenkins, T., Kaneshiro, E., Kehias, L., Sawdai, D., Watson, P., Welch, R., Worley, R., Yen, H.C.

“…We report on an ultra-efficient circuit at X-band and a linear-efficient circuit at Ka-band using InP double heterojunction bipolar transistors (DHBTs). The…”
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Studies on the A-ring diastereomers of 1α,25-dihydroxyvitamin D3 by RAMAN MURALIDHARAN, K, DE LERA, A. R, ISAEFF, S. D, NORMAN, A. W, OKAMURA, W. H

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Conformationally restricted mimics of vitamin D rotamers by Okamura, William H., Do, Steven, Kim, Hoim, Jeganathan, S., Vu, Thong, Zhu, Gui-Dong, Norman, Anthony W.

“…Drug developments in the vitamin D field have continued to focus on structure-function studies of analogs produced by chemically modifying the structure of…”
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