Search Results - "Okamura, Tomio"

Cigarette smoking impairs nitric oxide-mediated cerebral blood flow increase: Implications for Alzheimer's disease by Toda, Noboru, Okamura, Tomio

“…Cerebral blood flow is mainly regulated by nitrergic (parasympathetic, postganglionic) nerves and nitric oxide (NO) liberated from endothelial cells in…”
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Factors influencing the soluble guanylate cyclase heme redox state in blood vessels by Tawa, Masashi, Okamura, Tomio

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Cerebral Blood Flow Regulation by Nitric Oxide: Recent Advances by Toda, Noboru, Ayajiki, Kazuhide, Okamura, Tomio

“…Nitric oxide (NO) is undoubtedly quite an important intercellular messenger in cerebral and peripheral hemodynamics. This molecule, formed by constitutive…”
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Hyperhomocysteinemia impairs regional blood flow: involvements of endothelial and neuronal nitric oxide by Toda, Noboru, Okamura, Tomio

“…Increasing evidence support the idea that hyperhomocysteinemia (HHcy) is responsible for pathogenesis underlying cerebral, coronary, renal, and other vascular…”
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Obesity impairs vasodilatation and blood flow increase mediated by endothelial nitric oxide: An overview by Toda, Noboru, Okamura, Tomio

“…Obesity dramatically increases the risk of development of cardiovascular and metabolic diseases. Endothelial dysfunction induced by obesity is an important…”
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Cerebral blood flow regulation by nitric oxide in Alzheimer's disease by Toda, Noboru, Okamura, Tomio

“…Cerebral hypoperfusion due to impaired bioavailability of nitric oxide (NO) synthesized by endothelial nitric oxide synthase and neuronal nitric oxide synthase…”
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Impact of cigarette smoking on nitric oxide-sensitive and nitric oxide-insensitive soluble guanylate cyclase-mediated vascular tone regulation by Tawa, Masashi, Kinoshita, Takeshi, Masuoka, Takayoshi, Yamashita, Yuka, Nakano, Katsuya, Nishio, Matomo, Okamura, Tomio, Ishibashi, Takaharu

“…Cigarette smoking induces vascular endothelial dysfunction characterized by impaired nitric oxide (NO) bioavailability. There are two types of soluble…”
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Alteration of nitric oxide-mediated blood flow regulation in diabetes mellitus by Toda, Noboru, Imamura, Takeshi, Okamura, Tomio

“…Nitric oxide (NO) formed via endothelial NO synthase (eNOS) and neuronal NO synthase (nNOS) plays crucial roles in the regulation of blood flow through…”
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Segmental Difference in Vasoreactivity of the Human Right Gastroepiploic Artery by Kinoshita, Takeshi, Tawa, Masashi, Suzuki, Tomoaki, Asai, Tohru, Okamura, Tomio

“…Background:The gastroepiploic artery (GEA) plays an important role in the era of multiple arterial revascularization, but spasm is a major matter of concern…”
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The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels by Toda, Noboru, Okamura, Tomio

“…Unanticipated, novel hypothesis on nitric oxide (NO) radical, an inorganic, labile, gaseous molecule, as a neurotransmitter first appeared in late 1989 and…”
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4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation by Ishikado, Atsushi, Morino, Katsutaro, Nishio, Yoshihiko, Nakagawa, Fumiyuki, Mukose, Atsushi, Sono, Yoko, Yoshioka, Nagisa, Kondo, Keiko, Sekine, Osamu, Yoshizaki, Takeshi, Ugi, Satoshi, Uzu, Takashi, Kawai, Hiromichi, Makino, Taketoshi, Okamura, Tomio, Yamamoto, Masayuki, Kashiwagi, Atsunori, Maegawa, Hiroshi

“…Recent studies have proposed that n-3 polyunsaturated fatty acids (n-3 PUFAs) have direct antioxidant and anti-inflammatory effects in vascular tissue,…”
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Cerebral blood flow regulation by nitric oxide in neurological disorders by Toda, Noboru, Ayajiki, Kazuhide, Okamura, Tomio

“…There has been a rapid increase in the amount of information on the physiological and pathophysiological roles of nitric oxide (NO) in the brain. This…”
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Suppression of Graft Spasm by the Particulate Guanylyl Cyclase Activator in Coronary Bypass Surgery by Kinoshita, Takeshi, MD, PhD, Tawa, Masashi, PhD, Suzuki, Tomoaki, MD, PhD, Aimi, Yoshinari, MD, PhD, Asai, Tohru, MD, PhD, Okamura, Tomio, MD, PhD

“…Background Spasm of arterial grafts is still a clinical problem in coronary artery bypass surgery. The present study was designed to examine the effect of…”
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Chronological Change of Vascular Reactivity to cGMP Generators in the Balloon-Injured Rat Carotid Artery by Tawa, Masashi, Shimosato, Takashi, Sakonjo, Hiroshi, Masuoka, Takayoshi, Nishio, Matomo, Ishibashi, Takaharu, Okamura, Tomio

“…Soluble guanylate cyclase (sGC) exists as reduced, oxidized, and heme-free forms. Currently, it is unclear whether endovascular mechanical stenosis has an…”
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Soluble guanylate cyclase redox state under oxidative stress conditions in isolated monkey coronary arteries by Tawa, Masashi, Okamura, Tomio

“…Coronary artery disease is associated with oxidative stress due to the excessive generation of free radicals in the vascular wall. This study investigated the…”
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Regulation of myometrial circulation and uterine vascular tone by constitutive nitric oxide by Toda, Noboru, Toda, Hiroshi, Okamura, Tomio

“…Pregnancy is a physiological state that involves an increase in uterine blood flow, which is mediated in part by nitric oxide (NO) liberated from the…”
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Modulation of renal blood flow and vascular tone by neuronal nitric oxide synthase-derived nitric oxide by Toda, Noboru, Okamura, Tomio

“…Nitric oxide (NO) formed via neuronal nitric oxide synthase (nNOS) in renal vasculature and tissues and in the brain plays an important role in controlling…”
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Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase by Toda, Noboru, Ayajiki, Kazuhide, Okamura, Tomio

“…Nitric oxide formed by neuronal nitric oxide synthase (nNOS) in the brain, autonomic inhibitory (nitrergic) nerves, and heart plays important roles in the…”
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Effects of Atorvastatin, Amlodipine, and Their Combination on Vascular Dysfunction in Insulin-Resistant Rats by Okamura, Tomio, Tawa, Masashi, Geddawy, Ayman, Shimosato, Takashi, Iwasaki, Hirotaka, Shintaku, Haruo, Yoshida, Yuichi, Masada, Masahiro, Shinozaki, Kazuya, Imamura, Takeshi

“…Deficiency of tetrahydrobiopterin (BH4) in the vascular tissue contributes to endothelial dysfunction through reduced eNOS activity and increased superoxide…”
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Chronic Administration of Nicotine-Free Cigarette Smoke Extract Impaired Endothelium-Dependent Vascular Relaxation in Rats via Increased Vascular Oxidative Stress by Shimosato, Takashi, Geddawy, Ayman, Tawa, Masashi, Imamura, Takeshi, Okamura, Tomio

“…Cigarette smoking has been implicated in the initiation and progression of cardiovascular disorders and atherosclerosis. Here, we examined the effects of…”
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