Search Results - "Okamura, A."

Principal Component Analysis to Distinguish Seizure Liability of Drugs in Human iPS Cell-Derived Neurons by Ishibashi, Y, Odawara, A, Kinoshita, K, Okamura, A, Shirakawa, T, Suzuki, I

“…Abstract Screening for drug discovery targeting the central nervous system requires the establishment of efficient and highly accurate toxicity test methods…”
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Raster plots machine learning to predict the seizure liability of drugs and to identify drugs by Matsuda, N., Odawara, A., Kinoshita, K., Okamura, A., Shirakawa, T., Suzuki, I.

“…In vitro microelectrode array (MEA) assessment using human induced pluripotent stem cell (iPSC)-derived neurons holds promise as a method of seizure and…”
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Mechanics of Flexible Needles Robotically Steered through Soft Tissue by Misra, S., Reed, K.B., Schafer, B.W., Ramesh, K.T., Okamura, A.M.

“…The tip asymmetry of a bevel-tip needle results in the needle naturally bending when it is inserted into soft tissue. This enables robotic needle steering,…”
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Verification of the seizure liability of compounds based on their in vitro functional activity in cultured rat cortical neurons and co-cultured human iPSC-derived neurons with astrocytes and in vivo extrapolation to cerebrospinal fluid concentration by Ishibashi, Y., Nagafuku, N., Kinoshita, K., Okamura, A., Shirakawa, T., Suzuki, I.

“…Methodical screening of safe and efficient drug candidate compounds is crucial for drug development. A high-throughput and accurate compound evaluation method…”
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Methods for haptic feedback in teleoperated robot-assisted surgery by Okamura, A.M.

“…Teleoperated minimally invasive surgical robots can significantly enhance a surgeon's accuracy, dexterity and visualization. However, current commercially…”
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Oesophagectomy with or without supraclavicular lymphadenectomy after neoadjuvant treatment for squamous cell carcinoma of the oesophagus by Mine, S., Watanabe, M., Kumagai, K., Okamura, A., Yamashita, K., Hayami, M., Yuda, M., Imamura, Y., Ishizuka, N.

“…Background Treatment of supraclavicular nodes remains controversial among patients with oesophageal squamous cell carcinoma. This study assessed the outcomes…”
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Prospective Study of Dental Intervention for Hematopoietic Malignancy by Tsuji, K., Shibuya, Y., Akashi, M., Furudoi, S., Yakushijin, K., Kawamoto, S., Okamura, A., Matsuoka, H., Komori, T.

“…Various chemotherapeutic agents used in patients with hematopoietic malignancy cause serious side effects, including myelosuppression and immunosuppression…”
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Comparison of mediastinal lymph node metastases from adenocarcinoma of the esophagogastric junction versus lower esophageal squamous cell carcinoma with involvement of the esophagogastric junction by Mine, S, Watanabe, M, Kumagai, K, Okamura, A, Yuda, M, Hayami, M, Yamashita, K, Imamura, Y, Ishizuka, N

“…The distribution of mediastinal lymph node metastasis in patients with adenocarcinoma of the esophagogastric junction (AEG) remains unclear. Additionally, the…”
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Failure of neoadjuvant chemotherapy for resectable esophageal squamous cell carcinoma by Okamura, A., Watanabe, M., Mine, S., Kurogochi, T., Yamashita, K., Hayami, M., Imamura, Y., Ogura, M., Ichimura, T., Takahari, D., Chin, K.

“…Summary Neoadjuvant treatment has become standard care for patients with resectable esophageal cancer. However, some patients cannot undergo surgery or…”
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Construction and molecular characterization of a T-cell receptor-like antibody and CAR-T cells specific for minor histocompatibility antigen HA-1H by Inaguma, Y, Akahori, Y, Murayama, Y, Shiraishi, K, Tsuzuki-Iba, S, Endoh, A, Tsujikawa, J, Demachi-Okamura, A, Hiramatsu, K, Saji, H, Yamamoto, Y, Yamamoto, N, Nishimura, Y, Takahashi, T, Kuzushima, K, Emi, N, Akatsuka, Y

“…The genetic transfer of T-cell receptors (TCRs) directed toward target antigens into T lymphocytes has been used to generate antitumor T cells efficiently…”
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Evaluation of pharyngo‐oesophageal involvement in pemphigus vulgaris and its correlation with disease activity by Okamura, A., Nakamura, R., Yamagami, J., Ishii, K., Kawakubo, H., Omori, T., Takeuchi, H., Amagai, M., Kitagawa, Y.

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Influence of water temperature and feeding regime on otolith growth in Anguilla japonica glass eels and elvers: does otolith growth cease at low temperatures? by Fukuda, N., Kuroki, M., Shinoda, A., Yamada, Y., Okamura, A., Aoyama, J., Tsukamoto, K.

“…The influences of water temperature and feeding regime on otolith growth in Anguilla japonica glass eels and elvers were investigated using individuals reared…”
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Interleukin‐32 production associated with biliary innate immunity and proinflammatory cytokines contributes to the pathogenesis of cholangitis in biliary atresia by Okamura, A., Harada, K., Nio, M., Nakanuma, Y.

“…Summary Biliary atresia (BA) is thought to be associated with infections by viruses such as Reoviridae and is characterized histologically by fibrosclerosing…”
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Two types of strategies used by Japanese scientists, when writing research articles in English by Okamura, A.

“…In investigations of the second-language writing process the aim of interviews and questionnaires has often been to find shared difficulties among them…”
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Human-Machine Collaborative Systems for Microsurgical Applications by Kragic, D., Marayong, P., Li, M., Okamura, A. M., Hager, G. D.

“…Human-machine collaborative systems (HMCSs) are systems that amplify or assist human capabilities during the performance of tasks that require both human…”
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Force modeling for needle insertion into soft tissue by Okamura, A.M., Simone, C., O'Leary, M.D.

“…The modeling of forces during needle insertion into soft tissue is important for accurate surgical simulation, preoperative planning, and intelligent robotic…”
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The importance of organ geometry and boundary constraints for planning of medical interventions by Misra, S, Macura, K.J, Ramesh, K.T, Okamura, A.M

“…Abstract Realistic modeling of medical interventions involving tool–tissue interactions has been considered to be a key requirement in the development of…”
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Ontogenetic changes in phototactic behavior during metamorphosis of artificially reared Japanese eel Anguilla japonica larvae by Yamada, Y, Okamura, A, Mikawa, N, Utoh, T, Horie, N, Tanaka, S, Miller, MJ, Tsukamoto, K

“…The larvae of anguillid eels are termed leptocephali, among other reasons, because they differ greatly in morphology and physiology from other fish larvae…”
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The Impact of Early Rehabilitation on the Duration of Hospitalization in Patients After Allogeneic Hematopoietic Stem Cell Transplantation by Inoue, J, Ono, R, Okamura, A, Matsui, T, Takekoshi, H, Miwa, M, Kurosaka, M, Saura, R, Shimada, T

“…Abstract Background We examined the relationship between the improved physical activity by early rehabilitation and the duration of hospitalization among…”
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Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1 by Ramdhan, Doni Hikmat, Kamijima, Michihiro, Yamada, Naoyasu, Ito, Yuki, Yanagiba, Yukie, Nakamura, Daichi, Okamura, Ai, Ichihara, Gaku, Aoyama, Toshifumi, Gonzalez, Frank J., Nakajima, Tamie

“…Cytochrome P450 (CYP) 2E1 was suggested to be the major enzyme involved in trichloroethylene (TRI) metabolism and TRI-induced hepatotoxicity, although the…”
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