Search Results - "Okamoto, Yosuke"
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Effects of daytime light exposure on cognitive brain activity as measured by the ERP P300
Published in Physiology & behavior (01-01-2015)“…Abstract Exposure to light modulates not only human alertness but also cognitive functions. The present study examined the temporal dynamics of the effects of…”
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2
Molecular Pathogenesis of Cardiac Arrhythmia
Published in Biomolecules (Basel, Switzerland) (29-09-2022)“…The heart is a necessary organ for sustaining life in mammals, and it is the first organ to function during early development [...]…”
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Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes
Published in The Journal of biological chemistry (01-11-2019)“…Pulmonary veins (PVs) are the major origin of atrial fibrillation. Recently, we recorded hyperpolarization-activated Cl− current (ICl, h) in rat PV…”
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4
Azelnidipine treatment reduces the expression of Cav1.2 protein
Published in Life sciences (1973) (15-03-2021)“…Azelnidipine, a third-generation dihydropyridine calcium channel blocker (DHP CCB), has a characteristic hypotensive effect that persists even after it has…”
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5
Bioinformatic Identification of Potential RNA Alterations on the Atrial Fibrillation Remodeling from Human Pulmonary Veins
Published in International journal of molecular sciences (22-06-2023)“…Atrial fibrillation (AF) is the most frequent persistent arrhythmia. Many genes have been reported as a genetic background for AF. However, most transcriptome…”
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6
Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals
Published in Heart rhythm (01-07-2014)“…Background A reduction of complexity of heart beating interval variability that is associated with an increased morbidity and mortality in cardiovascular…”
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Pathological impact of hyperpolarization-activated chloride current peculiar to rat pulmonary vein cardiomyocytes
Published in Journal of molecular and cellular cardiology (01-01-2014)“…Abstract Pulmonary veins (PVs) are believed to be a crucial origin of atrial fibrillation. We recently reported that rat PV cardiomyocytes exhibit…”
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8
Small-volume vitrification and rapid warming yield high survivals of one-cell rat embryos in cryotubes
Published in Biology of reproduction (01-07-2021)“…To cryopreserve cells, it is essential to avoid intracellular ice formation during cooling and warming. One way to achieve this is to convert the water inside…”
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Comparative study of hyperpolarization-activated currents in pulmonary vein cardiomyocytes isolated from rat, guinea pig, and rabbit
Published in The journal of physiological sciences (11-02-2020)“…Pulmonary vein (PV) cardiomyocytes have the potential to generate spontaneous activity, in contrast to working myocytes of atria. Different…”
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10
Arrhythmogenic coupling between the Na+–Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes
Published in Journal of molecular and cellular cardiology (01-05-2012)“…Atrial fibrillation, the most common sustained arrhythmia, is believed to be triggered by ectopic electrical activity originating in the myocardial sleeves…”
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11
Mechanisms Underlying Spontaneous Action Potential Generation Induced by Catecholamine in Pulmonary Vein Cardiomyocytes: A Simulation Study
Published in International journal of molecular sciences (14-06-2019)“…Cardiomyocytes and myocardial sleeves dissociated from pulmonary veins (PVs) potentially generate ectopic automaticity in response to noradrenaline (NA), and…”
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12
Effects of light wavelength on MEG ERD/ERS during a working memory task
Published in International journal of psychophysiology (01-06-2016)“…We investigated the effects of light wavelengths on cortical oscillatory activity associated with working memory processes. Cortical activity responses were…”
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13
Direct Effects of Esmolol and Landiolol on Cardiac Function, Coronary Vasoactivity, and Ventricular Electrophysiology in Guinea-Pig Hearts
Published in Journal of Pharmacological Sciences (2012)“…The ultra-short acting, selective β1-adrenergic antagonists landiolol and esmolol are widely used perioperatively; however, little is known about their acute…”
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14
ERK5 Phosphorylates Kv4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells
Published in International journal of molecular sciences (10-07-2018)“…Extracellular signal-regulated kinase 5 (ERK5) regulates diverse physiological responses such as proliferation, differentiation, and gene expression…”
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Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells
Published in Journal of molecular and cellular cardiology (01-12-2014)“…Abstract Recent evidence indicates that the spontaneous action potential (AP) of isolated sinoatrial node cells (SANCs) is regulated by a system of stochastic…”
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16
Comparative Study of Transcriptome in the Hearts Isolated from Mice, Rats, and Humans
Published in Biomolecules (Basel, Switzerland) (20-06-2022)“…The heart is a significant organ in mammalian life, and the heartbeat mechanism has been an essential focus of science. However, few studies have focused on…”
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17
Simvastatin Induces the Odontogenic Differentiation of Human Dental Pulp Stem Cells In Vitro and In Vivo
Published in Journal of endodontics (01-03-2009)“…Abstract Statin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, is known to promote bone formation. However, it is not clear whether statin affects…”
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Preferential Expression of Ca2+-Stimulable Adenylyl Cyclase III in the Supraventricular Area, including Arrhythmogenic Pulmonary Vein of the Rat Heart
Published in Biomolecules (Basel, Switzerland) (20-05-2022)“…Ectopic excitability in pulmonary veins (PVs) is the major cause of atrial fibrillation. We previously reported that the inositol trisphosphate receptor in rat…”
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19
Temporal dynamics of EEG activity during short- and long-wavelength light exposures in the early morning
Published in BMC research notes (26-02-2014)“…It is well known that exposure to light, especially of short wavelength, enhances human alertness during the nighttime. However, more information is needed to…”
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Effect of skip lymphovascular invasion on hepatic metastasis in colorectal carcinomas
Published in International journal of clinical oncology (01-08-2015)“…Background “Skip” lymphovascular invasion presenting as discontinuous foci of tumor cells within the colon wall is now excluded from consideration when…”
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