Search Results - "Okada, Naoki"

Impact of scFv structure in chimeric antigen receptor on receptor expression efficiency and antigen recognition properties by Fujiwara, Kento, Masutani, Mizuki, Tachibana, Masashi, Okada, Naoki

“…Gene-modifying T cells expressing chimeric antigen receptor (CAR) with an extracellular domain consisting of single chain variable fragment (scFv) and an…”
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Leaf vascular architecture in temperate dicotyledons: correlations and link to functional traits by Kawai, Kiyosada, Okada, Naoki

“…Main conclusions Using 227 dicotyledonous species in temperate region, we found the relationships among densities of different-order veins, creating diversity…”
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How are leaf mechanical properties and water‐use traits coordinated by vein traits? A case study in Fagaceae by Kawai, Kiyosada, Okada, Naoki, Watling, Jenny

“…Leaf venation is a key trait determining leaf water relations, phloem transport and mechanical stability. However, since the contribution of leaf veins to…”
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New clinical diagnostic criteria for allergic bronchopulmonary aspergillosis/mycosis and its validation by Asano, Koichiro, Hebisawa, Akira, Ishiguro, Takashi, Takayanagi, Noboru, Nakamura, Yasuhiko, Suzuki, Junko, Okada, Naoki, Tanaka, Jun, Fukutomi, Yuma, Ueki, Shigeharu, Fukunaga, Koichi, Konno, Satoshi, Matsuse, Hiroto, Kamei, Katsuhiko, Taniguchi, Masami, Shimoda, Terufumi, Oguma, Tsuyoshi

“…There are several clinical diagnostic criteria for allergic bronchopulmonary aspergillosis (ABPA). However, these criteria have not been validated in detail,…”
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Clinical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch by Hirobe, Sachiko, Azukizawa, Hiroaki, Hanafusa, Takaaki, Matsuo, Kazuhiko, Quan, Ying-Shu, Kamiyama, Fumio, Katayama, Ichiro, Okada, Naoki, Nakagawa, Shinsaku

“…Abstract Transcutaneous immunization (TCI) is an attractive vaccination method compared with conventional injectable vaccines because it is easier to…”
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Tetrameric and Hexameric Porphyrin Nanorings: Template Synthesis and Photophysical Properties by Maeda, Chihiro, Toyama, Shoki, Okada, Naoki, Takaishi, Kazuto, Kang, Seongsoo, Kim, Dongho, Ema, Tadashi

“…Hexameric and tetrameric porphyrin nanorings, Z6·T6 and Z4·T4, were synthesized in 53% and 14% yields, respectively, by the Sonogashira-type…”
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The Effects of Chimeric Antigen Receptor (CAR) Hinge Domain Post-Translational Modifications on CAR-T Cell Activity by Hirobe, Sachiko, Imaeda, Keisuke, Tachibana, Masashi, Okada, Naoki

“…To improve the efficacy and safety of chimeric antigen receptor (CAR)-expressing T cell therapeutics through enhanced CAR design, we analysed CAR structural…”
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Roles of major and minor vein in leaf water deficit tolerance and structural properties in 11 temperate deciduous woody species by Kawai, Kiyosada, Okada, Naoki

“…Key message Minor vein traits have a stronger association with leaf water deficit tolerance and structural properties than major veins in deciduous woody…”
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Efficacy and safety of nintedanib for pulmonary fibrosis in severe pneumonia induced by COVID-19: An interventional study by Umemura, Yutaka, Mitsuyama, Yumi, Minami, Kensuke, Nishida, Takeshi, Watanabe, Atsushi, Okada, Naoki, Yamakawa, Kazuma, Nochioka, Kotaro, Fujimi, Satoshi

“…One of the most significant features of poor prognosis in COVID-19 is pulmonary fibrosis. Nintedanib is a new antifibrotic agent that interferes with processes…”
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Valproic acid attenuates immunosuppressive function of myeloid-derived suppressor cells by Xie, Zhiqi, Ago, Yukio, Okada, Naoki, Tachibana, Masashi

“…Immune checkpoint blockade (ICB) is a promising novel therapy for multiple cancer types; however, most patients show limited or no clinical response…”
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Rapid clearance of mepolizumab-resistant bronchial mucus plugs in allergic bronchopulmonary aspergillosis with benralizumab treatment by Tomomatsu, Katsuyoshi, Sugino, Yasuteru, Okada, Naoki, Tanaka, Jun, Oguma, Tsuyoshi, Asano, Koichiro

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Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold by Fujiwara, Kento, Tsunei, Ayaka, Kusabuka, Hotaka, Ogaki, Erika, Tachibana, Masashi, Okada, Naoki

“…Chimeric antigen receptor (CAR)-T cells have demonstrated significant clinical potential; however, their strong antitumor activity may cause severe adverse…”
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Immunogenicity of Milk Protein-Containing Hydrophilic Gel Patch for Epicutaneous Immunotherapy for Milk Allergy by Ito, Sayami, Hirobe, Sachiko, Kuwabara, Yu, Nagao, Mizuho, Saito, Mio, Quan, Ying-Shu, Kamiyama, Fumio, Fujisawa, Takao, Okada, Naoki

“…Purpose Epicutaneous immunotherapy (EPIT) involving the skin’s immune system is easy to use, painless and has a low risk of systemic side effects; it can be…”
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HIV-associated CD8+ T-cell Skin Infiltrative Disease and EBV-associated Polymorphic B-cell Lymphoproliferative Disorder in an AIDS Patient Who Improved Dramatically with Antiretroviral Therapy Alone by Okada, Naoki, Saito, Kenki, Watanabe, Momoko, Ohtani, Toshio, Notohara, Kenji, Wada, Hideho, Ueda, Yasunori

“…Human immunodeficiency virus (HIV)-associated CD8+ T-cell skin infiltrative disease with severe erythroderma has rarely been reported. While HIV-positive…”
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Valproic acid attenuates CCR2-dependent tumor infiltration of monocytic myeloid-derived suppressor cells, limiting tumor progression by Xie, Zhiqi, Ikegami, Tamami, Ago, Yukio, Okada, Naoki, Tachibana, Masashi

“…Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that promote tumor progression by inhibiting anti-tumor immunity and may be the cause of…”
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Structure of the Signal Transduction Domain in Second-Generation CAR Regulates the Input Efficiency of CAR Signals by Fujiwara, Kento, Kitaura, Masaki, Tsunei, Ayaka, Kusabuka, Hotaka, Ogaki, Erika, Okada, Naoki

“…T cells that are genetically engineered to express chimeric antigen receptor (CAR) have a strong potential to eliminate tumor cells, yet the CAR-T cells may…”
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Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice by Xie, Zhiqi, Zhou, Haoyang, Obana, Masanori, Fujio, Yasushi, Okada, Naoki, Tachibana, Masashi

“…Viral pneumonia is a global health burden with a high mortality rate, especially in the elderly and in patients with underlying diseases. Recent studies have…”
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Combination therapy for hepatocellular carcinoma with diacylglycerol kinase alpha inhibition and anti-programmed cell death-1 ligand blockade by Okada, Naoki, Sugiyama, Ko, Shichi, Shunsuke, Shirai, Yasuhito, Goto, Kaoru, Sakane, Fumio, Kitamura, Hidemitsu, Taketomi, Akinobu

“…Activation of diacylglycerol kinase alpha (DGKα) augments proliferation and suppresses apoptosis of cancer cells and induces T lymphocyte anergy. We…”
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Analysis of Skin Permeability and Toxicological Properties of Amorphous Silica Particles by Matsuo, Kazuhiko, Hirobe, Sachiko, Okada, Naoki, Nakagawa, Shinsaku

“…Nanomaterials (NMs) are defined as those which have nanostructured components less than 100 nm in diameter. They are widely used in various fields such as…”
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Characteristics of immune induction by transcutaneous vaccination using dissolving microneedle patches in mice by Hirobe, Sachiko, Susai, Ryo, Takeuchi, Honoka, Eguchi, Ryosuke, Ito, Sayami, Quan, Ying-Shu, Kamiyama, Fumio, Okada, Naoki

“…[Display omitted] •We conducted transcutaneous vaccination using a dissolving microneedle patch.•We verified the immune induction mechanism of transcutaneous…”
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