Search Results - "Okada, Muneyoshi"

A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain by Okada, Muneyoshi, Yamawaki, Hideyuki

“…Type IV collagen is a main component of basement membrane extracellular matrix. Canstatin, a non-collagenous C-terminal fragment of type IV collagen α2 chain,…”
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Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts by Kanazawa, Hiroki, Imoto, Keisuke, Okada, Muneyoshi, Yamawaki, Hideyuki

“…A hypoxic stress which causes apoptosis of cardiomyocytes is the main problem in the ischemic heart disease. Canstatin, a non-collagenous fragment of type IV…”
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Histone Deacetylase 4 Controls Neointimal Hyperplasia via Stimulating Proliferation and Migration of Vascular Smooth Muscle Cells by Usui, Tatsuya, Morita, Tomoka, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Histone deacetylases (HDACs) are transcriptional coregulators. Recently, we demonstrated that HDAC4, one of class IIa family members, promotes reactive oxygen…”
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Eukaryotic elongation factor 2 kinase inhibitor, A484954 lowered blood pressure in spontaneously hypertensive rats via inducing vasorelaxation by Kodama, Tomoko, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) suppresses protein translation. We previously reported eEF2K expression was upregulated in mesenteric…”
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Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension by Yamamoto, Atsunori, Otani, Kosuke, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Adipocytokine chemerin is a biologically active molecule secreted from adipose tissue. Chemerin elicits a variety of functions via chemokine-like receptor 1…”
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Long-term administration of recombinant canstatin prevents adverse cardiac remodeling after myocardial infarction by Sugiyama, Akira, Ito, Rumi, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Myocardial infarction (MI) still remains a leading cause of mortality throughout the world. An adverse cardiac remodeling, such as hypertrophy and fibrosis, in…”
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Adipocytokine, omentin inhibits doxorubicin-induced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species by Kazama, Kyosuke, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Omentin is a relatively novel adipocyte-derived cytokine mainly expressed in visceral adipose tissues. Blood omentin level decreases in the patients with…”
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Protective effect of T3 peptide, an active fragment of tumstatin, against ischemia/reperfusion injury in rat heart by Yasuda, Jumpei, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Ischemia/reperfusion (I/R)-induced oxidative stress is a serious clinical problem in the reperfusion therapy for ischemic diseases. Tumstatin is an endogenous…”
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Preventive Effect of Canstatin against Ventricular Arrhythmia Induced by Ischemia/Reperfusion Injury: A Pilot Study by Sugiyama, Akira, Shimizu, Yurie, Okada, Muneyoshi, Otani, Kosuke, Yamawaki, Hideyuki

“…Ventricular arrhythmia induced by ischemia/reperfusion (I/R) injury is a clinical problem in reperfusion therapies for acute myocardial infarction. Ca overload…”
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Endostatin stimulates proliferation and migration of adult rat cardiac fibroblasts through PI3K/Akt pathway by Okada, Muneyoshi, Oba, Yoko, Yamawaki, Hideyuki

“…Endostatin, a non-collagenous fragment of type XVIII collagen, has anti-angiogenic roles. Although the expression level of endostatin increases in some…”
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Death-Associated Protein Kinase 3 Mediates Vascular Inflammation and Development of Hypertension in Spontaneously Hypertensive Rats by Usui, Tatsuya, Okada, Muneyoshi, Hara, Yukio, Yamawaki, Hideyuki

“…Death-associated protein kinase (DAPK) is a Ca/calmodulin-regulated serine/threonine kinase that mediates cell death. Our recent study demonstrated that DAPK3…”
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Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes by Otani, Kosuke, Funada, Hiroshi, Teranishi, Risa, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Zucker fatty diabetes mellitus (ZFDM) rats harboring the missense mutation (fa) in a leptin receptor gene have been recently established as a novel animal…”
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Mechanisms underlying the relaxation by A484954, a eukaryotic elongation factor 2 kinase inhibitor, in rat isolated mesenteric artery by Kodama, Tomoko, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Eukaryotic elongation factor 2 kinase (eEF2K) is a calmodulin-related protein kinase which regulates protein translation. A484954 is an inhibitor of eEF2K. In…”
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Pathophysiological roles of canstatin on myofibroblasts after myocardial infarction in rats by Sugiyama, Akira, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Myofibroblasts play an important role during remodeling process after myocardial infarction through proliferation, migration, production and degradation of…”
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Chemerin promotes the proliferation and migration of vascular smooth muscle and increases mouse blood pressure by Kunimoto, Hidemizu, Kazama, Kyosuke, Takai, Mizuho, Oda, Mayuko, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Blood chemerin concentration shows positive correlation not only with body mass index and serum triglyceride level but also with systolic blood pressure. While…”
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Eukaryotic elongation factor 2 kinase inhibitor, A484954 induced diuresis via nitric oxide production in spontaneously hypertensive rats by KODAMA, Tomoko, OTANI, Kosuke, OKADA, Muneyoshi, YAMAWAKI, Hideyuki

“…Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a protein kinase that inactivates eEF2, a protein that mediates a peptidyl-tRNA translocation during an…”
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Endostatin Stimulates Proliferation and Migration of Myofibroblasts Isolated from Myocardial Infarction Model Rats by Sugiyama, Akira, Hirano, Yuka, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Myofibroblasts contribute to the healing of infarcted areas after myocardial infarction through proliferation, migration, and production of extracellular…”
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Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling by Kameshima, Satoshi, Kazama, Kyosuke, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Pulmonary arterial (PA) hypertension (PAH) is a progressive and lethal disease that is caused by increased vascular contractile reactivity and structural…”
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Optimal Isolation Method of Small Extracellular Vesicles from Rat Plasma by Otani, Kosuke, Fujioka, Yusei, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Small extracellular vesicles (sEVs) mediate cell-to-cell communication. We recently reported that circulating sEVs regulate systolic blood pressure in an…”
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A novel adipocytokine, omentin, inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell migration through antioxidative mechanism by Kazama, Kyosuke, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Omentin is a novel adipocytokine expressed in visceral adipose tissue. Secretion and blood concentration of omentin decrease in the obese subjects. We…”
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