Search Results - "Okada, Kumiko"

A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells by Kasahara, Nanaho, Imi, Yukiko, Amano, Reina, Shinohara, Masakazu, Okada, Kumiko, Hosokawa, Yusei, Imamori, Makoto, Tomimoto, Chiaki, Kunisawa, Jun, Kishino, Shigenobu, Ogawa, Jun, Ogawa, Wataru, Hosooka, Tetsuya

“…The antidiabetic drug pioglitazone ameliorates insulin resistance by activating the transcription factor PPARγ. In addition to its blood glucose–lowering…”
Get full text

Muscle Protein Dok-7 Is Essential for Neuromuscular Synaptogenesis by Okada, Kumiko, Inoue, Akane, Okada, Momoko, Murata, Yoji, Kakuta, Shigeru, Jigami, Takafumi, Kubo, Sachiko, Shiraishi, Hirokazu, Eguchi, Katsumi, Motomura, Masakatsu, Akiyama, Tetsu, Iwakura, Yoichiro, Higuchi, Osamu, Yamanashi, Yuji

“…The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the…”
Get full text

Modulation of lipid mediator profile may contribute to amelioration of chronic inflammation in adipose tissue of obese mice by pioglitazone by Okada, Kumiko, Hosooka, Tetsuya, Shinohara, Masakazu, Ogawa, Wataru

“…Thiazolidinediones exert their antidiabetic effect in part by ameliorating chronic inflammation in adipose tissue. However, the precise mechanism of this…”
Get full text

Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation by Inoue, Akane, Setoguchi, Kiyoko, Matsubara, Yosuke, Okada, Kumiko, Sato, Nozomi, Iwakura, Yoichiro, Higuchi, Osamu, Yamanashi, Yuji

“…The formation of the neuromuscular junction (NMJ) is orchestrated by the muscle-specific receptor tyrosine kinase MuSK and by neural agrin, an extracellular…”
Get more information

Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway by Nakajima, Kuniko, Inagawa, Masayo, Uchida, Chiharu, Okada, Kumiko, Tane, Shoji, Kojima, Mizuyo, Kubota, Misae, Noda, Masatsugu, Ogawa, Satoko, Shirato, Haruki, Sato, Michio, Suzuki-Migishima, Rika, Hino, Toshiaki, Satoh, Yukio, Kitagawa, Masatoshi, Takeuchi, Takashi

“…In general, cell proliferation and differentiation show an inverse relationship, and are regulated in a coordinated manner during development. Embryonic…”
Get full text

Total synthesis of spiruchostatin B aided by an automated synthesizer by Fuse, Shinichiro, Okada, Kumiko, Iijima, Yusuke, Munakata, Asami, Machida, Kazuhiro, Takahashi, Takashi, Takagi, Motoki, Shin-ya, Kazuo, Doi, Takayuki

“…The total synthesis of a natural product HDAC inhibitor, spiruchostatin B, was successfully achieved. A 5-step synthesis that included an asymmetric aldol…”
Get more information

Design, synthesis and biological evaluation of novel pyridine derivatives as gut-selective NaPi2b inhibitors by Ushiki, Yasunobu, Kawabe, Kenichi, Yamamoto-Okada, Kumiko, Uneuchi, Fumito, Asanuma, Yuta, Yamaguchi, Chitose, Ohta, Hiroshi, Shibata, Tsuyoshi, Abe, Tomohiro, Okumura-Kitajima, Lisa, Kosai, Yuki, Endo, Mayumi, Otake, Katsumasa, Munetomo, Eiji, Takahashi, Teisuke, Kakinuma, Hiroyuki

“…[Display omitted] We previously reported thiophene derivatives as gut-selective (minimally systemic) and potent sodium-dependent phosphate transport protein 2b…”
Get full text

Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitors by Ushiki, Yasunobu, Kawabe, Kenichi, Yamamoto-Okada, Kumiko, Uneuchi, Fumito, Asanuma, Yuta, Yamaguchi, Chitose, Ohta, Hiroshi, Shibata, Tsuyoshi, Abe, Tomohiro, Okumura-Kitajima, Lisa, Kosai, Yuki, Endo, Mayumi, Otake, Katsumasa, Munetomo, Eiji, Takahashi, Teisuke, Kakinuma, Hiroyuki

“…[Display omitted] Intestinal sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors are expected to be potential new candidates for…”
Get full text

Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective NaPi2b inhibitors by Ushiki, Yasunobu, Kawabe, Kenichi, Yamamoto-Okada, Kumiko, Uneuchi, Fumito, Asanuma, Yuta, Yamaguchi, Chitose, Ohta, Hiroshi, Shibata, Tsuyoshi, Abe, Tomohiro, Okumura-Kitajima, Lisa, Kosai, Yuki, Endo, Mayumi, Otake, Katsumasa, Munetomo, Eiji, Takahashi, Teisuke, Kakinuma, Hiroyuki

“…[Display omitted] Intestinal sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors are expected to be potential new candidates for…”
Get full text

Effective use of the Pig-a gene mutation assay for mutagenicity screening: measuring CD59-deficient red blood cells in rats treated with genotoxic chemicals by Kimoto, Takafumi, Chikura, Satsuki, Suzuki-Okada, Kumiko, Kobayashi, Xiao-mei, Itano, Yasuhiro, Miura, Daishiro, Kasahara, Yoshinori

“…The Pig-a gene mutation assay using perpherial blood erythrocytes is being investigated as a screening tool for assessing mutagenicity in vivo. In this study,…”
Get full text

Recombinant aryl hydrocarbon receptors for bioassay of aryl hydrocarbon receptor ligands in transgenic tobacco plants by Kodama, Susumu, Okada, Kumiko, Akimoto, Keiko, Inui, Hideyuki, Ohkawa, Hideo

“…Dioxin residues widely contaminate soil and agricultural products at low concentrations and may accumulate in organisms at the top of food chains owing to…”
Get more information

Mutations Causing DOK7 Congenital Myasthenia Ablate Functional Motifs in Dok-7 by Hamuro, Johko, Higuchi, Osamu, Okada, Kumiko, Ueno, Makiko, Iemura, Shun-ichiro, Natsume, Tohru, Spearman, Hayley, Beeson, David, Yamanashi, Yuji

“…Dok-7 is a cytoplasmic activator of muscle-specific receptor-tyrosine kinase (MuSK). Both Dok-7 and MuSK are required for neuromuscular synaptogenesis…”
Get full text

Abstract PO2-06-04: Prospective study on eribulin efficacy in advanced and metastatic breast cancer: changes in TGF-β compared to other standard chemotherapy agents (KBCSG-TR 2018, POTENTIAL) by Nakayama, Takahiro, Yoshinami, Tersuhiro, Fujisawa, Fumie, Nishio, Minako, Yamanaka, Takashi, Yamashita, Toshinari, Oshiro, Chiya, Izui, Ayaka, Tomioka, Nobumoto, Maeda, Hideki, Shimoda, Masafumi, Shimazu, Kenzo, Tsuneizumi, Michiko, Matsunuma, Ryoichi, Bando, Hiroko, Ueda, Aya, Yasojima, Hiroyuki, Okada, Kumiko, Inoue, Kenichi, Kai, Yuichiro, Yoshidome, Katsuhide, Kawaguchi, Hidetoshi, Nagahashi, Masayuki, Oshima, Kazuteru, Kashiwagi, Shinichiro, Iwasa, Tsutomu, Taruno, Kanae, Tsuyuki, Shigeru, Tsukamoto, Fumine, Morimoto, Takashi, Kittaka, Nobuyoshi, Higuchi, Toru, Naito, Yoichi, Saita, Ryotaro, Nishikawa, Hiroyoshi, Sugiyama, Daisuke, Miyoshi, Yasuo, Uchida, Yohei, Yamada, Tomomi, Masuda, Norikazu

“…Introduction Eribulin (E) has been demonstrated to improve overall survival (OS) compared to standard chemotherapies in pivotal phase III clinical trials…”
Get full text

Salt Effect on Critical Micelle Concentrations of Nonionic Surfactants, N-Acyl-N-methylglucamides (MEGA-n) by Miyagishi, Shigeyoshi, Okada, Kumiko, Asakawa, Tsuyoshi

“…Salting-out effects on critical micelle concentrations (cmc's) of N-acyl-N-methylglucamides (MEGA-8, -9, and -10) were examined for 16 kinds of salts. The…”
Get full text

Effective use of the Pig-a gene mutation assay for mutagenicity screening by Kimoto, Takafumi, Chikura, Satsuki, Suzuki-Okada, Kumiko, Kobayashi, Xiao-mei, Itano, Yasuhiro, Miura, Daishiro, Kasahara, Yoshinori

“…The Pig-a gene mutation assay using perpherial blood erythrocytes is being investigated as a screening tool for assessing mutagenicity in vivo. In this study,…”
Get full text

Aryl hydrocarbon receptor (AhR)-mediated reporter gene expression systems in transgenic tobacco plants by Kodama, Susumu, Okada, Kumiko, Inui, Hideyuki, Ohkawa, Hideo

“…In mammals, the aryl hydrocarbon receptor (AhR) mediates expression of certain genes, including CYP1A1, in response to exposure to dioxins and related…”
Get full text

Oxidation of 7,8-diaminotheophylline with lead tetraacetate and reaction of the oxidation product, 6-cyanoimino-5-diazo-1,3-dimethylpyrimidine-2,4-dione with alcohols or amines by Ueda, Taisei, Yatsuzuka, Naoyoshi, Nagai, Shin-Ichi, Okada, Kumiko, Takeichi, Emi, Segi, Hiromi, Sakakibara, Jinsaku

“…Oxidation of 7,8‐diaminotheophylline (1) with lead tetraacetate in refluxing toluene gave a mixture of…”
Get full text