Search Results - "Oka, J A"

IgA induced activation of human mesangial cells: Independent of FcαR1 (CD 89) by Diven, Steven C., Caflisch, Carlton R., Hammond, Dianne K., Weigel, Paul H., Oka, Janet A., Goldblum, Randall M.

“…IgA induced activation of human mesangial cells: Independent of FcαR1 (CD 89). IgA nephropathy (IgAN) is characterized by deposition of polymers of IgA1 in the…”
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Hyperosmolarity inhibits galactosyl receptor-mediated but not fluid phase endocytosis in isolated rat hepatocytes by Oka, J A, Christensen, M D, Weigel, P H

“…We have investigated the effects of hyperosmolarity induced by sucrose on the fluid phase endocytosis of the fluorescent dye lucifer yellow CH (LY) and the…”
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Regulation of asialoglycoprotein receptor activity by a novel inactivation/reactivation cycle. Receptor reactivation in permeable rat hepatocytes is mediated by fatty acyl coenzyme A by Weigel, P H, Oka, J A

“…We previously reported that a subpopulation of asialoglycoprotein receptors (ASGP-Rs), designated State 2 ASGP-Rs, can be inactivated in…”
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The large intracellular pool of asialoglycoprotein receptors functions during the endocytosis of asialoglycoproteins by isolated rat hepatocytes by Weigel, P H, Oka, J A

“…The function of intracellular asialoglycoprotein receptors during the endocytosis of asialo-orosomucoid in isolated hepatocytes was assessed by following…”
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The surface content of asialoglycoprotein receptors on isolated hepatocytes is reversibly modulated by changes in temperature by Weigel, P H, Oka, J A

“…We have investigated the effect of temperature on the content of surface asialoglycoprotein receptors on isolated rat hepatocytes. Receptor was determined by…”
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Ethanol Feeding Causes Inactivation of Both State 1 and State 2 Rat Hepatic Asialoglycoprotein Receptors by Tworek, Benita L., Oka, Janet A., Casey, Carol A., Weigel, Paul H.

“…Previous studies have shown that ethanol feeding in rats causes inactivation and redistribution of ˜50% of the total asialoglycoprotein receptors (ASGPRs) in…”
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Recycling of the asialoglycoprotein receptor in isolated rat hepatocytes. Dissociation of internalized ligand from receptor occurs in two kinetically and thermally distinguishable compartments by Oka, J A, Weigel, P H

“…We have examined the rate of dissociation of internalized 125I-asialo-orosomucoid-receptor complexes in freshly isolated rat hepatocytes. Cell suspensions were…”
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Degradation of asialoglycoproteins mediated by the galactosyl receptor system in isolated hepatocytes. Evidence for two parallel pathways by Clarke, B L, Oka, J A, Weigel, P H

“…The ability of rat hepatocytes to degrade internalized surface-bound 125I-asialoorosomucoid (ASOR) was determined by measuring the appearance of acid-soluble…”
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Temperature dependence of endocytosis mediated by the asialoglycoprotein receptor in isolated rat hepatocytes. Evidence for two potentially rate-limiting steps by Weigel, P H, Oka, J A

“…The rate of endocytosis of cell surface-bound [3H]-asialo-orosomucoid was determined as a function of temperature. Freshly isolated rat hepatocytes were…”
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Recycling of the hepatic asialoglycoprotein receptor in isolated rat hepatocytes. Receptor-ligand complexes in an intracellular slowly dissociating pool return to the cell surface prior to dissociation by Weigel, P H, Oka, J A

“…We recently reported that the dissociation of internalized receptor-125I-asialo-orosomucoid (ASOR) complexes by isolated hepatocytes is a biphasic process;…”
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The surface activity of the same subpopulation of galactosyl receptors on isolated rat hepatocytes is modulated by colchicine, monensin, ATP depletion, and chloroquine by MCABEE, D. D, CLARKE, B. L, OKA, J. A, WEIGEL, P. H

“…In this study, we characterized and compared the ligand-independent loss of surface galactosyl (Gal) receptor activity on isolated rat hepatocytes treated with…”
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The rat hepatic lectin 1 subunit of the rat asialoglycoprotein receptor is a phosphoprotein and contains phosphotyrosine by Haynes, P A, Oka, J A, Weigel, P H

“…The rat asialoglycoprotein receptor (ASGPR) is an integral transmembrane glycoprotein composed of three polypeptide subunits, designated rat hepatic lectins…”
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Endocytosis and degradation mediated by the asialoglycoprotein receptor in isolated rat hepatocytes by Weigel, P H, Oka, J A

“…super(125)I- and ( super(3)H)asialo-orosomucoid were compared and found to be virtually equivalent probes with respect to their binding to and endocytosis into…”
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Binding and spreading of hepatocytes on synthetic galactose culture surfaces occur as distinct and separable threshold responses by Oka, J A, Weigel, P H

“…Isolated rat hepatocytes bind to synthetic flat polyacrylamide matrices containing covalently attached galactose residues in a sugar-specific and…”
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Purification and Subunit Characterization of the Rat Liver Endocytic Hyaluronan Receptor by Zhou, B, Oka, J A, Singh, A, Weigel, P H

“…The endocytic hyaluronan (HA) receptor of liver sinusoidal endothelial cells (LECs) is responsible for the clearance of HA and other glycosaminoglycans from…”
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The pathways for fluid phase and receptor mediated endocytosis in rat hepatocytes are different but thermodynamically equivalent by Oka, J A, Weigel, P H

“…In isolated rat hepatocytes fluid phase endocytosis, determined by the uptake of the fluorescent dye lucifer yellow (LY), and receptor mediated endocytosis,…”
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Quantitation of intracellular membrane-bound enzymes and receptors in digitonin-permeabilized cells by Weigel, P H, Ray, D A, Oka, J A

“…The distribution of membrane-bound receptors and enzymes between the cell surface and the cell interior can be determined without solubilization or gross…”
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Vanadate modulates the activity of a subpopulation of asialoglycoprotein receptors on isolated rat hepatocytes: active surface receptors are internalized and replaced by inactive receptors by Oka, J A, Weigel, P H

“…In the absence of ligand, sodium vanadate causes a time- and dose-dependent loss of up to approximately 50% of the surface galactosyl receptor (GalR) activity…”
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Monensin inhibits ligand dissociation only transiently and partially and distinguishes two galactosyl receptor pathways in isolated rat hepatocytes by Oka, J A, Weigel, P H

“…Monensin has been shown to inhibit the dissociation of internalized asialoorosomucoid (ASOR) from galactosyl (Gal) receptors in hepatocytes (Harford et al., J…”
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Coated pits and asialoglycoprotein receptors redistribute to the substratum during hepatocyte adhesion to galactoside surfaces by Weigel, P H, Oka, J A

“…Rat hepatocytes bind in a sugar-specific and concentration-dependent manner to flat polyacrylamide matrices containing covalently attached galactosyl (Gal)…”
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