Search Results - "Oka, Hisayoshi"

Comparisons of cardiovascular dysautonomia and cognitive impairment between de novo Parkinson’s disease and de novo dementia with Lewy bodies by Oka, Hisayoshi, Umehara, Tadashi, Nakahara, Atsuo, Matsuno, Hiromasa

“…Abstract Background Cognitive impairment may be correlated with cardiovascular dysautonomia, including blood pressure (BP) dysregulation, in Parkinson’s…”
Get full text

Endosomal dysfunction in iPSC-derived neural cells from Parkinson’s disease patients with VPS35 D620N by Bono, Keiko, Hara-Miyauchi, Chikako, Sumi, Shunsuke, Oka, Hisayoshi, Iguchi, Yasuyuki, Okano, Hirotaka James

“…Abstract Mutations in the Vacuolar protein sorting 35 ( VPS35 ) gene have been linked to familial Parkinson’s disease (PD), PARK17. VPS35 is a key component of…”
Get full text

Rasagiline does not exacerbate autonomic blood pressure dysregulation in early or mild Parkinson’s disease by Oka, Hisayoshi, Sengoku, Renpei, Nakahara, Atsuo, Yamazaki, Mikihiro

“…•Blood pressure dysregulation is important in Parkinson’s disease.•Anti-Parkinsonian drugs that have less effect on blood pressure should be used.•Some…”
Get full text

Clinical and neuroendocrinological characteristics of delayed orthostatic hypotension in Parkinson’s disease by Shiraishi, Tomotaka, Umehara, Tadashi, Oka, Hisayoshi, Nakahara, Atsuo, Sato, Takeo, Matsuno, Hiromasa, Komatsu, Teppei, Omoto, Shusaku, Murakami, Hidetomo, Iguchi, Yasuyuki

“…Purpose Delayed orthostatic hypotension (DOH), a fall in blood pressure after a 3-min cutoff, is clinically meaningful. The aim of this study was to elucidate…”
Get full text

Olfactory dysfunction and cardiovascular dysautonomia in Parkinson’s disease by Oka, Hisayoshi, Toyoda, Chizuko, Yogo, Makiko, Mochio, Soichiro

“…Several studies have reported that olfactory dysfunction is an early neuropathological manifestation of Parkinson’s disease (PD). Reduced cardiac…”
Get full text

Sympathetic nervous activity and hemoglobin levels in de novo Parkinson’s disease by Umehara, Tadashi, Oka, Hisayoshi, Nakahara, Atsuo, Shiraishi, Tomotaka, Sato, Takeo, Matsuno, Hiromasa, Komatsu, Teppei, Omoto, Shusaku, Murakami, Hidetomo, Iguchi, Yasuyuki

“…Purpose Sympathetic nervous denervation may be associated with the development of anemia. We aimed to investigate the association between sympathetic nervous…”
Get full text

Risk factors, etiology, and outcome of ischemic stroke in young adults: A Japanese multicenter prospective study by Kono, Yu, Terasawa, Yuka, Sakai, Kenichiro, Iguchi, Yasuyuki, Nishiyama, Yasuhiro, Nito, Chikako, Suda, Satoshi, Kimura, Kazumi, Kanzawa, Takao, Imafuku, Ichiro, Nakayama, Takahiro, Ueda, Masayuki, Iwanaga, Takeshi, Kono, Tomoyuki, Yamashiro, Kazuo, Tanaka, Ryota, Okubo, Seiji, Nakajima, Makoto, Nakajima, Nobuhito, Mishina, Masahiro, Yaguchi, Hiroshi, Oka, Hisayoshi, Suzuki, Masahiko, Osaki, Masato, Kaneko, Nobuyuki, Kitagawa, Kazuo, Okamoto, Sadahisa, Nomura, Koichi, Yamazaki, Mineo, Nagao, Takehiko, Murakami, Yoshitaka

“…This study aimed to evaluate the risk factors, etiology, and outcomes of ischemic stroke (IS) in Japanese young adults. This was a prospective multicenter…”
Get full text

Reduced cardiac 123I-MIBG uptake reflects cardiac sympathetic dysfunction in de novo Parkinson’s disease by Oka, Hisayoshi, Toyoda, Chizuko, Yogo, Makiko, Mochio, Soichiro

“…It remains unclear whether cardiac iodine-123-labeled metaiodobenzylguanidine ( 123 I-MIBG) uptake is clinically related to autonomic dysfunction on…”
Get full text

Differential leukocyte count is associated with clinical phenotype in Parkinson's disease by Umehara, Tadashi, Oka, Hisayoshi, Nakahara, Atsuo, Matsuno, Hiromasa, Murakami, Hidetomo

“…Elevated proinflammatory cytokines are associated with disease progression in patients with Parkinson's disease (PD). The aim of study is to investigate…”
Get full text

The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease by Shiraishi, Tomotaka, Bono, Keiko, Hiraki, Hiromi, Manome, Yoko, Oka, Hisayoshi, Iguchi, Yasuyuki, Okano, Hirotaka James

“…VPS35 plays a key role in neurodegenerative processes in Alzheimer’s disease and Parkinson’s disease (PD). Many genetic studies have shown a close relationship…”
Get full text

Association between sebum secretion and cardiac sympathetic dysfunction in Parkinson's disease by Kitagawa, Tomomichi, Sengoku, Renpei, Ozawa, Masakazu, Matsuno, Hiromasa, Umehara, Tadashi, Nakahara, Atsuo, Oka, Hisayoshi

“…Patients with Parkinson's disease (PD) have α-synuclein (α-Syn) deposition in the skin, and decreased sebum secretion due to epidermal dysfunction. However,…”
Get full text

Frontal lobe dysfunction is associated with reduced DAT-SPECT accumulation in Lewy body disease by Nakahara, Atsuo, Sengoku, Renpei, Umehara, Tadashi, Matsuno, Hiromasa, Yamazaki, Mikihiro, Oka, Hisayoshi

“…Lewy body disease (LBD) causes olfactory or cognitive dysfunction even before motor symptoms emerge. Recent reports indicate that the dopamine transporter…”
Get full text

Predictors of postprandial hypotension in elderly patients with de novo Parkinson’s disease by Umehara, Tadashi, Nakahara, Atsuo, Matsuno, Hiromasa, Toyoda, Chizuko, Oka, Hisayoshi

“…Postprandial hypotension is one of the most important autonomic disorders in Parkinson’s disease. However, its predictors remain unclear. We investigated which…”
Get full text

Clinical characteristics of supine hypertension in de novo Parkinson disease by Umehara, Tadashi, Matsuno, Hiromasa, Toyoda, Chizuko, Oka, Hisayoshi

“…Purpose Supine hypertension is frequently associated with autonomic failure. However, its clinical characteristics in patients with Parkinson disease (PD)…”
Get full text

Serum phosphorus levels associated with nigrostriatal dopaminergic deficits in drug-naïve Parkinson's disease by Umehara, Tadashi, Mimori, Masahiro, Kokubu, Tatsushi, Ozawa, Masakazu, Shiraishi, Tomotaka, Sato, Takeo, Onda, Asako, Matsuno, Hiromasa, Omoto, Shusaku, Murakami, Hidetomo, Oka, Hisayoshi, Iguchi, Yasuyuki

“…A major component of Lewy bodies is phosphorylated α-synuclein. This post-translational modification of α-synuclein, phosphorylation, may consume a great…”
Get full text

High norepinephrinergic orthostatic hypotension in early Parkinson's disease by Umehara, Tadashi, Oka, Hisayoshi, Nakahara, Atsuo, Matsuno, Hiromasa, Toyoda, Chizuko

“…Plasma norepinephrine concentration reflects lesions causing OH. We investigate whether patients with high norepinephrinergic orthostatic hypotension (OH)…”
Get full text

Peripheral immune profile in drug-naïve dementia with Lewy bodies by Umehara, Tadashi, Mimori, Masahiro, Kokubu, Tatsushi, Ozawa, Masakazu, Shiraishi, Tomotaka, Sato, Takeo, Onda, Asako, Matsuno, Hiromasa, Omoto, Shusaku, Sengoku, Renpei, Murakami, Hidetomo, Oka, Hisayoshi, Iguchi, Yasuyuki

“…Background Accumulating evidence suggests that peripheral inflammation is associated with the pathogenesis of Parkinson’s disease (PD). We examined peripheral…”
Get full text

Postprandial hypotension in de novo Parkinson's disease: A comparison with orthostatic hypotension by Umehara, Tadashi, Toyoda, Chizuko, Oka, Hisayoshi

“…Abstract Background Postprandial hypotension (PPH) is often associated with Parkinson's disease (PD). However, its mechanism remains to be fully defined. We…”
Get full text

Thyroid hormone level is associated with motor symptoms in de novo Parkinson’s disease by Umehara, Tadashi, Matsuno, Hiromasa, Toyoda, Chizuko, Oka, Hisayoshi

“…Sympathetic denervation has been observed not only in the myocardium but also in the thyroid of patients with Parkinson’s disease (PD). We investigated whether…”
Get full text

Association between heart rate variability and striatal dopamine depletion in Parkinson’s disease by Kitagawa, Tomomichi, Umehara, Tadashi, Oka, Hisayoshi, Shiraishi, Tomotaka, Sato, Takeo, Takatsu, Hiroki, Nakahara, Atsuo, Matsuno, Hiromasa, Bono, Keiko, Omoto, Shusaku, Murakami, Hidetomo, Sengoku, Renpei, Iguchi, Yasuyuki

“…Striatal dopamine depletion is associated with not only motor symptom but also non-motor symptoms in patients with Parkinson’s disease (PD). The purpose is to…”
Get full text