Search Results - "Ojima, Hidenori"

Landscape of immune microenvironment in hepatocellular carcinoma and its additional impact on histological and molecular classification by Kurebayashi, Yutaka, Ojima, Hidenori, Tsujikawa, Hanako, Kubota, Naoto, Maehara, Junki, Abe, Yuta, Kitago, Minoru, Shinoda, Masahiro, Kitagawa, Yuko, Sakamoto, Michiie

“…Immune cells constitute an important element of tumor tissue. Accumulating evidence indicates their clinicopathological significance in predicting prognosis…”
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Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma by Arai, Yasuhito, Totoki, Yasushi, Hosoda, Fumie, Shirota, Tomoki, Hama, Natsuko, Nakamura, Hiromi, Ojima, Hidenori, Furuta, Koh, Shimada, Kazuaki, Okusaka, Takuji, Kosuge, Tomoo, Shibata, Tatsuhiro

“…Cholangiocarcinoma is an intractable cancer, with limited therapeutic options, in which the molecular mechanisms underlying tumor development remain poorly…”
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Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer by Fujimoto, Akihiro, Furuta, Mayuko, Totoki, Yasushi, Tsunoda, Tatsuhiko, Kato, Mamoru, Shiraishi, Yuichi, Tanaka, Hiroko, Taniguchi, Hiroaki, Kawakami, Yoshiiku, Ueno, Masaki, Gotoh, Kunihito, Ariizumi, Shun-ichi, Wardell, Christopher P, Hayami, Shinya, Nakamura, Toru, Aikata, Hiroshi, Arihiro, Koji, Boroevich, Keith A, Abe, Tetsuo, Nakano, Kaoru, Maejima, Kazuhiro, Sasaki-Oku, Aya, Ohsawa, Ayako, Shibuya, Tetsuo, Nakamura, Hiromi, Hama, Natsuko, Hosoda, Fumie, Arai, Yasuhito, Ohashi, Shoko, Urushidate, Tomoko, Nagae, Genta, Yamamoto, Shogo, Ueda, Hiroki, Tatsuno, Kenji, Ojima, Hidenori, Hiraoka, Nobuyoshi, Okusaka, Takuji, Kubo, Michiaki, Marubashi, Shigeru, Yamada, Terumasa, Hirano, Satoshi, Yamamoto, Masakazu, Ohdan, Hideki, Shimada, Kazuaki, Ishikawa, Osamu, Yamaue, Hiroki, Chayama, Kazuki, Miyano, Satoru, Aburatani, Hiroyuki, Shibata, Tatsuhiro, Nakagawa, Hidewaki

“…Hidewaki Nakagawa and colleagues report a comprehensive genome-wide mutational landscape of 300 liver cancers from Japanese individuals. They identify…”
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Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer by Shibata, Tatsuhiro, Kokubu, Akiko, Gotoh, Masahiro, Ojima, Hidenori, Ohta, Tsutomu, Yamamoto, Masayuki, Hirohashi, Setsuo

“…Background & Aims: Biliary tract cancer (BTC) is a highly malignant tumor, and identification of effective therapeutic targets to improve prognosis is urgently…”
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Immunovascular classification of HCC reflects reciprocal interaction between immune and angiogenic tumor microenvironments by Kurebayashi, Yutaka, Matsuda, Kosuke, Ueno, Akihisa, Tsujikawa, Hanako, Yamazaki, Ken, Masugi, Yohei, Kwa, Wit Thun, Effendi, Kathryn, Hasegawa, Yasushi, Yagi, Hiroshi, Abe, Yuta, Kitago, Minoru, Ojima, Hidenori, Sakamoto, Michiie

“…Background and Aims Immune cells and tumor vessels constitute important elements in tumor tissue; however, their detailed relationship in human tumors,…”
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Aberrant DNA methylation results in altered gene expression in non-alcoholic steatohepatitis-related hepatocellular carcinomas by Tian, Ying, Arai, Eri, Makiuchi, Satomi, Tsuda, Noboru, Kuramoto, Junko, Ohara, Kentaro, Takahashi, Yoriko, Ito, Nanako, Ojima, Hidenori, Hiraoka, Nobuyoshi, Gotoh, Masahiro, Yoshida, Teruhiko, Kanai, Yae

“…Purpose The aim of this study was to investigate DNA methylation alterations in non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinomas (HCCs)…”
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Characterization of spatial distribution of tumor-infiltrating CD8+ T cells refines their prognostic utility for pancreatic cancer survival by Masugi, Yohei, Abe, Tokiya, Ueno, Akihisa, Fujii-Nishimura, Yoko, Ojima, Hidenori, Endo, Yutaka, Fujita, Yusuke, Kitago, Minoru, Shinoda, Masahiro, Kitagawa, Yuko, Sakamoto, Michiie

“…The abundance of cytotoxic T-cell infiltrates has important implications for patient outcome and therapeutic design for pancreatic ductal adenocarcinoma…”
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Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells by Sakamoto, Akihisa, Hino, Shinjiro, Nagaoka, Katsuya, Anan, Kotaro, Takase, Ryuta, Matsumori, Haruka, Ojima, Hidenori, Kanai, Yae, Arita, Kazunori, Nakao, Mitsuyoshi

“…The hallmark of most cancer cells is the metabolic shift from mitochondrial to glycolytic metabolism for adapting to the surrounding environment. Although…”
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Silencing of microRNA‐122 is an early event during hepatocarcinogenesis from non‐alcoholic steatohepatitis by Takaki, Yoko, Saito, Yoshimasa, Takasugi, Azusa, Toshimitsu, Kohta, Yamada, Shoji, Muramatsu, Toshihide, Kimura, Masaki, Sugiyama, Kazuo, Suzuki, Hiromu, Arai, Eri, Ojima, Hidenori, Kanai, Yae, Saito, Hidetsugu

“…Non‐alcoholic steatohepatitis (NASH) has emerged as a common cause of chronic liver disease and virus‐independent hepatocellular carcinoma (HCC) in patients…”
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Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity by Fujimoto, Akihiro, Furuta, Mayuko, Shiraishi, Yuichi, Gotoh, Kunihito, Kawakami, Yoshiiku, Arihiro, Koji, Nakamura, Toru, Ueno, Masaki, Ariizumi, Shun-ichi, Hai Nguyen, Ha, Shigemizu, Daichi, Abe, Tetsuo, Boroevich, Keith A., Nakano, Kaoru, Sasaki, Aya, Kitada, Rina, Maejima, Kazihiro, Yamamoto, Yujiro, Tanaka, Hiroko, Shibuya, Tetsuo, Shibata, Tatsuhiro, Ojima, Hidenori, Shimada, Kazuaki, Hayami, Shinya, Shigekawa, Yoshinobu, Aikata, Hiroshi, Ohdan, Hideki, Marubashi, Shigeru, Yamada, Terumasa, Kubo, Michiaki, Hirano, Satoshi, Ishikawa, Osamu, Yamamoto, Masakazu, Yamaue, Hiroki, Chayama, Kazuaki, Miyano, Satoru, Tsunoda, Tatsuhiko, Nakagawa, Hidewaki

“…Intrahepatic cholangiocarcinoma and combined hepatocellular cholangiocarcinoma show varying degrees of biliary epithelial differentiation, which can be defined…”
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Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan™) platform by Qiao, Zhiwei, Pan, Xiaoqing, Parlayan, Cuneyd, Ojima, Hidenori, Kondo, Tadashi

“…Vascular invasion is a pathological hallmark of hepatocellular carcinoma (HCC), associated with poor prognosis; it is strongly related to the early recurrence…”
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FOXP3+ Regulatory T Cells Affect the Development and Progression of Hepatocarcinogenesis by KOBAYASHI, Noritoshi, HIRAOKA, Nobuyoshi, YAMAGAMI, Wataru, OJIMA, Hidenori, KANAI, Yae, KOSUGE, Tomoo, NAKAJIMA, Atsushi, HIROHASHI, Setsuo

“…Purpose: Tumor-infiltrating lymphocytes represent the host immune response to cancer. CD4 + CD25 + FOXP3 + regulatory T cells (Tregs) suppress the immune…”
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High-resolution characterization of a hepatocellular carcinoma genome by Totoki, Yasushi, Tatsuno, Kenji, Yamamoto, Shogo, Arai, Yasuhito, Hosoda, Fumie, Ishikawa, Shumpei, Tsutsumi, Shuichi, Sonoda, Kohtaro, Totsuka, Hirohiko, Shirakihara, Takuya, Sakamoto, Hiromi, Wang, Linghua, Ojima, Hidenori, Shimada, Kazuaki, Kosuge, Tomoo, Okusaka, Takuji, Kato, Kazuto, Kusuda, Jun, Yoshida, Teruhiko, Aburatani, Hiroyuki, Shibata, Tatsuhiro

“…Tatsuhiro Shibata and colleagues report the sequencing of a hepatocellular carcinoma. The authors identified 63 somatic non-synonymous substitutions and 22…”
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Establishment of various biliary tract carcinoma cell lines and xenograft models for appropriate preclinical studies by Ojima, Hidenori, Yamagishi, Seri, Shimada, Kazuaki, Shibata, Tatsuhiro

“…We recently reported several driver genes of biliary tract carcinoma(BTC) that are known to play important roles in oncogenesis and disease progression…”
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Steatotic and nonsteatotic scirrhous hepatocellular carcinomas reveal distinct clinicopathological features by Hatano, Mami, Ojima, Hidenori, Masugi, Yohei, Tsujikawa, Hanako, Hiraoka, Nobuyoshi, Kanai, Yae, Shimada, Kazuaki, Shinoda, Masahiro, Sakamoto, Michiie

“…We investigated the clinicopathological and molecular characteristics of scirrhous hepatocellular carcinoma (HCC) to elucidate its uniqueness. Samples from 120…”
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PI3K-mTOR pathway identified as a potential therapeutic target in biliary tract cancer using a newly established patient-derived cell panel assay by Sakamoto, Yasunari, Yamagishi, Seri, Tanizawa, Yoshinori, Tajimi, Masaomi, Okusaka, Takuji, Ojima, Hidenori

“…We evaluated four new molecular targeting agents using our cell line panel with 17 biliary tract carcinoma cell lines. PI3K/mTOR inhibitor showed promising…”
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Precision pathology analysis of the development and progression of hepatocellular carcinoma: Implication for precision diagnosis of hepatocellular carcinoma by Ueno, Akihisa, Masugi, Yohei, Yamazaki, Ken, Kurebayashi, Yutaka, Tsujikawa, Hanako, Effendi, Kathryn, Ojima, Hidenori, Sakamoto, Michiie

“…Outcomes for patients with hepatocellular carcinoma (HCC) remain poor because the condition is often unresponsive to the available treatments. Consequently,…”
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Extrahepatic approach for taping the common trunk of the middle and left hepatic veins or the left hepatic vein alone in laparoscopic hepatectomy (with videos) by Nakano, Yutaka, Abe, Yuta, Kitago, Minoru, Yagi, Hiroshi, Hasegawa, Yasushi, Hori, Shutaro, Koizumi, Wataru, Ojima, Hidenori, Imanishi, Nobuaki, Kitagawa, Yuko

“…Background Outflow control is difficult, and techniques required for effectively handling intraoperative hemorrhage during laparoscopic hepatectomy have not…”
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Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma by Kondo, Shunsuke, Ojima, Hidenori, Tsuda, Hitoshi, Hashimoto, Jun, Morizane, Chigusa, Ikeda, Masafumi, Ueno, Hideki, Tamura, Kenji, Shimada, Kazuaki, Kanai, Yae, Okusaka, Takuji

“…Background c-Met is an oncogene encoding a receptor for hepatocyte growth factor and, as such, plays a key role in hepatocellular carcinomas (HCC). We…”
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DNA methylation status of the SPHK1 and LTB genes underlies the clinicopathological diversity of non-alcoholic steatohepatitis-related hepatocellular carcinomas by Tsuda, Noboru, Tian, Ying, Fujimoto, Mao, Kuramoto, Junko, Makiuchi, Satomi, Ojima, Hidenori, Gotoh, Masahiro, Hiraoka, Nobuyoshi, Yoshida, Teruhiko, Kanai, Yae, Arai, Eri

“…Purpose This study was performed to identify the DNA methylation profiles underlying the clinicopathological diversity of non-alcoholic steatohepatitis…”
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