Search Results - "Ojala, Juha R.M."

The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen by Swystun, Laura L., Ogiwara, Kenichi, Lai, Jesse D., Ojala, Juha R. M., Rawley, Orla, Lassalle, Fanny, Notley, Colleen, Rengby, Olle, Michels, Alison, Nesbitt, Kate, Tryggvason, Karl, Lillicrap, David

“…Background Scavenger receptors play a significant role in clearing aged proteins from the plasma, including the large glycoprotein coagulation factors von…”
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Lmx1b and FoxC combinatorially regulate podocin expression in podocytes by He, Bing, Ebarasi, Lwaki, Zhao, Zhe, Guo, Jing, Ojala, Juha R M, Hultenby, Kjell, De Val, Sarah, Betsholtz, Christer, Tryggvason, Karl

“…Podocin is a key protein of the kidney podocyte slit diaphragm protein complex, an important part of the glomerular filtration barrier. Mutations in the human…”
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Crystal Structure of the Cysteine-rich Domain of Scavenger Receptor MARCO Reveals the Presence of a Basic and an Acidic Cluster That Both Contribute to Ligand Recognition by Ojala, Juha R.M., Pikkarainen, Timo, Tuuttila, Ari, Sandalova, Tatyana, Tryggvason, Karl

“…MARCO is a trimeric class A scavenger receptor of macrophages and dendritic cells that recognizes polyanionic particles and pathogens. The distal, scavenger…”
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Ab initio solution of macromolecular crystal structures without direct methods by McCoy, Airlie J., Oeffner, Robert D., Wrobel, Antoni G., Ojala, Juha R. M., Tryggvason, Karl, Lohkamp, Bernhard, Read, Randy J.

“…The majority of macromolecular crystal structures are determined using the method of molecular replacement, in which known related structures are rotated and…”
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Culturing functional pancreatic islets on α5-laminins and curative transplantation to diabetic mice by Sigmundsson, Kristmundur, Ojala, Juha R.M., Öhman, Miina K., Österholm, Anne-May, Moreno-Moral, Aida, Domogatskaya, Anna, Chong, Li Yen, Sun, Yang, Chai, Xiaoran, Steele, Joseph A.M., George, Benjamin, Patarroyo, Manuel, Nilsson, Ann-Sofie, Rodin, Sergey, Ghosh, Sujoy, Stevens, Molly M., Petretto, Enrico, Tryggvason, Karl

“…The efficacy of islet transplantation for diabetes treatment suffers from lack of cadaver-derived islets, islet necrosis and long transfer times prior to…”
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Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information by Horejs, Christine-Maria, St-Pierre, Jean-Philippe, Ojala, Juha R. M., Steele, Joseph A. M., da Silva, Patricia Barros, Rynne-Vidal, Angela, Maynard, Stephanie A., Hansel, Catherine S., Rodríguez-Fernández, Clara, Mazo, Manuel M., You, Amanda Y. F., Wang, Alex J., von Erlach, Thomas, Tryggvason, Karl, López-Cabrera, Manuel, Stevens, Molly M.

“…Matrix metalloproteinases (MMPs) contribute to the breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis. Here we developed…”
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Genetic and biological effects of sodium-chloride cotransporter (SLC12A3) in diabetic nephropathy by Abu Seman, Norhashimah, He, Bing, Ojala, Juha R M, Wan Mohamud, Wan Nazaimoon, Östenson, Claes-Göran, Brismar, Kerstin, Gu, Harvest F

“…Solute carrier family 12 member 3 (SLC12A3) encodes a sodium/chloride transporter in kidneys. Previous reports suggest that Arg913Gln polymorphism in this gene…”
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Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes by Mao, Jianhua, Wang, Dayan, Mataleena, Parikka, He, Bing, Niu, Dadi, Katayama, Kan, Xu, Xiangjun, Ojala, Juha Rm, Wang, Wenjing, Shu, Qiang, Du, Lizhong, Liu, Aimin, Pikkarainen, Timo, Patrakka, Jaakko, Tryggvason, Karl

“…Podocytes serve as an important constituent of the glomerular filtration barrier. Recently, we and others identified Myo1e as a key molecular component of the…”
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A remote cis-acting variant at 3q links glomerular NCK1 to diabetic nephropathy by He, Bing, Österholm, Anne-May, Ojala, Juha R M, Andersson, Ann-Charlotte, Tryggvason, Karl

“…We have previously reported genetic association of a single nucleotide polymorphism (SNP), rs1866813, at 3q locus with increased risk of diabetic nephropathy…”
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A Phage Display Screen and Binding Studies with Acetylated Low Density Lipoprotein Provide Evidence for the Importance of the Scavenger Receptor Cysteine-rich (SRCR) Domain in the Ligand-binding Function of MARCO by Chen, Yunying, Sankala, Marko, Ojala, Juha R.M., Sun, Yi, Tuuttila, Ari, Isenman, David E., Tryggvason, Karl, Pikkarainen, Timo

“…MARCO is a class A scavenger receptor capable of binding both Gram-negative and -positive bacteria. Using the surface plasmon resonance technique, we show here…”
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