Search Results - "Oitzl, M. S."

Relevance of Stress and Female Sex Hormones for Emotion and Cognition by ter Horst, J. P., de Kloet, E. R., Schächinger, H., Oitzl, M. S.

“…There are clear sex differences in incidence and onset of stress-related and other psychiatric disorders in humans. Yet, rodent models for psychiatric…”
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Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior by Fitzsimons, C P, van Hooijdonk, L W A, Schouten, M, Zalachoras, I, Brinks, V, Zheng, T, Schouten, T G, Saaltink, D J, Dijkmans, T, Steindler, D A, Verhaagen, J, Verbeek, F J, Lucassen, P J, de Kloet, E R, Meijer, O C, Karst, H, Joels, M, Oitzl, M S, Vreugdenhil, E

“…Glucocorticoids (GCs) secreted after stress reduce adult hippocampal neurogenesis, a process that has been implicated in cognitive aspects of psychopathology,…”
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Stress or no stress: Mineralocorticoid receptors in the forebrain regulate behavioral adaptation by ter Horst, J.P., van der Mark, M.H., Arp, M., Berger, S., de Kloet, E.R., Oitzl, M.S.

“…► This study demonstrates the relevance of MR for adaptive behavior. ► MR forebrain deficient mice (MRCaMKCre) need more time to learn a spatial task. ► Stress…”
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Stress and estrous cycle affect strategy but not performance of female C57BL/6J mice by ter Horst, J.P., Kentrop, J., de Kloet, E.R., Oitzl, M.S.

“…► There is a sex difference in the use of learning strategies. ► Stress induces a switch from stimulus–response toward spatial strategy in female mice. ►…”
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Mineralocorticoid receptors in control of emotional arousal and fear memory by Brinks, V., Berger, S., Gass, P., de Kloet, E.R., Oitzl, M.S.

“…The stress hormone corticosterone acts via two receptor types in the brain: the mineralocorticoid (MR) and the glucocorticoid receptor (GR). Both receptors are…”
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Hypothalamic-Pituitary-Adrenal Axis Activity of Newborn Mice Rapidly Desensitizes to Repeated Maternal Absence but Becomes Highly Responsive to Novelty by Enthoven, L, Oitzl, M. S, Koning, N, van der Mark, M, de Kloet, E. R

“…In CD1 mice we investigated the hypothalamic-pituitary-adrenal (HPA) axis response to maternal separation for 8 h daily from postnatal d 3 to 5. At d 3 a slow…”
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Corticosterone facilitates extinction of fear memory in BALB/c mice but strengthens cue related fear in C57BL/6 mice by Brinks, V., de Kloet, E.R., Oitzl, M.S.

“…Corticosterone, the naturally occurring glucocorticoid of rodents is secreted in response to stressors and is known for its facilitating and detrimental…”
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Sex differences in fear memory and extinction of mice with forebrain-specific disruption of the mineralocorticoid receptor by ter Horst, J. P., Carobrez, A. P., van der Mark, M. H., de Kloet, E. R., Oitzl, M. S.

“…Previous studies showed that the mineralocorticoid receptor (MR) is needed for behavioral flexibility in a fear conditioning paradigm. Female mice with…”
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Stress and cognition: are corticosteroids good or bad guys? by de Kloet, E. Ron, Oitzl, Melly S., Joëls, Marian

“…Corticosteroid hormones secreted by the adrenal cortex protect the brain against adverse events and are essential for cognitive performance. However, in recent…”
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Recovery from Disrupted Ultradian Glucocorticoid Rhythmicity Reveals a Dissociation Between Hormonal and Behavioural Stress Responsiveness by Sarabdjitsingh, R. A., Spiga, F., Oitzl, M. S., Kershaw, Y., Meijer, O. C., Lightman, S. L., De Kloet, E. R.

“…Ultradian release of glucocorticoids is thought to be essential for homeostasis and health. Furthermore, deviation from this pulsatile release pattern is…”
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The Dynamics of the Hypothalamic-Pituitary-Adrenal Axis During Maternal Deprivation by Schmidt, M., Enthoven, L., Van Woezik, J. H. G., Levine, S., De Kloet, E. R., Oitzl, M. S.

“…A close contact between the dam and the litter is essential for the normal development of the hypothalamic‐pituitary‐adrenal (HPA) axis in rats and mice…”
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Glucocorticoid Receptor Blockade Disinhibits Pituitary-Adrenal Activity during the Stress Hyporesponsive Period of the Mouse by Schmidt, M, Levine, S, Oitzl, M. S, van der Mark, M, Müller, M. B, Holsboer, F, de Kloet, E. R

“…During postnatal development, mice undergo a period of reduced responsiveness of the pituitary-adrenal axis, the stress hyporesponsive period (SHRP), which is…”
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The postnatal development of the hypothalamic–pituitary–adrenal axis in the mouse by Schmidt, M., Enthoven, L., Mark, M., Levine, S., Kloet, E.R., Oitzl, M.S.

“…The main characteristic of the postnatal development of the stress system in the rat is the so‐called stress hypo‐responsive period (SHRP). Lasting from…”
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Correlations between Hypothalamus-Pituitary-Adrenal Axis Parameters Depend on Age and Learning Capacity by Meijer, O. C, Topic, B, Steenbergen, P. J, Jocham, G, Huston, J. P, Oitzl, M. S

“…Glucocorticoid hormones are released after activation of the hypothalamus-pituitary-adrenal (HPA) axis and in the brain can modulate synaptic plasticity and…”
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Differential and Age-Dependent Effects of Maternal Deprivation on the Hypothalamic-Pituitary-Adrenal Axis of Brown Norway Rats from Youth to Senescence by Workel, J. O., Oitzl, M. S., Fluttert, M., Lesscher, H., Karssen, A., De Kloet, E. R.

“…In this study, the hypothesis was tested that infants deprived from maternal care show persistent changes in hypothalamic‐pituitary‐adrenal activity. For this…”
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Effects of maternal deprivation of CD1 mice on performance in the water maze and swim stress by Enthoven, L., de Kloet, E.R., Oitzl, M.S.

“…Rat pups subjected to a single 24 h maternal deprivation show altered stress responsiveness and cognitive performance in the water maze in adulthood. Here we…”
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Maternal deprivation affects behaviour from youth to senescence: amplification of individual differences in spatial learning and memory in senescent Brown Norway rats by Oitzl, Melly S., Workel, Judith O., Fluttert, Marc, Frösch, Fawzia, De Kloet, E. Ron

“…Previous studies have shown that deprivation of the infant rat from maternal care has pronounced effects on the stress system during ontogeny. Here we test the…”
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Differential development of stress system (re)activity at weaning dependent on time of disruption of maternal care by Enthoven, L, de Kloet, E.R, Oitzl, M.S

“…Abstract Maternal deprivation, a separation of mother and pups for 24 h in the first weeks of life has long-lasting consequences for the glucocorticoid stress…”
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Brain mineralocorticoid receptors and centrally regulated functions by de Kloet, E. Ronald, van Acker, Saskia A.B.E., Sibug, Rosana M., Oitzl, Melly S., Meijer, Onno C., Rahmouni, Kamal, de Jong, Wybren

“…Brain mineralocorticoid receptors and centrally regulated functions. Mineralocorticoid receptors (MRs) expressed in limbic neurons, notably of hippocampus,…”
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Regulation of the developing hypothalamic–pituitary–adrenal axis in corticotropin releasing hormone receptor 1-deficient mice by Schmidt, M, Oitzl, M.S, Müller, M.B, Ohl, F, Wurst, W, Holsboer, F, Levine, S, De Kloet, E.R

“…During postnatal development, mice undergo a so-called stress hyporesponsive period, which is characterized by low basal corticosterone levels and the…”
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