Search Results - "Oikonen, V"

Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease by KEMPPAINEN, N. M, AALTO, S, PARKKOLA, R, RINNE, J. O, WILSON, I. A, NAGREN, K, HELIN, S, BRÜCK, A, OIKONEN, V, KAILAJÄRVI, M, SCHEININ, M, VIITANEN, M

“…PET studies with N-methyl-[(11)C]2-(4':-methylaminophenyl)-6-hydroxybenzothiazole ([(11)C]PIB) have revealed an increased tracer uptake in several brain…”
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PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment by KEMPPAINEN, N. M, AALTO, S, PARKKOLA, R, RINNE, J. O, WILSON, I. A, NAGREN, K, HELIN, S, BRÜCK, A, OIKONEN, V, KAILAJÄRVI, M, SCHEININ, M, VIITANEN, M

“…Patients with mild cognitive impairment (MCI) have increased risk to develop Alzheimer disease (AD). In AD increased brain amyloid burden has been demonstrated…”
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Validation of [18F]fluorodeoxyglucose and positron emission tomography (PET) for the measurement of intestinal metabolism in pigs, and evidence of intestinal insulin resistance in patients with morbid obesity by Honka, H., Mäkinen, J., Hannukainen, J. C., Tarkia, M., Oikonen, V., Teräs, M., Fagerholm, V., Ishizu, T., Saraste, A., Stark, C., Vähäsilta, T., Salminen, P., Kirjavainen, A., Soinio, M., Gastaldelli, A., Knuuti, J., Iozzo, P., Nuutila, P.

“…Aims/hypothesis The role of the intestine in the pathogenesis of metabolic diseases is gaining much attention. We therefore sought to validate, using an animal…”
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Cholinergic dysfunction after traumatic brain injury: Preliminary findings from a PET study by OSTBERG, A, VIRTA, J, RINNE, J. O, OIKONEN, V, LUOTO, P, NAGREN, K, ARPONEN, E, TENOVUO, O

“…There is evidence that the cholinergic system is frequently involved in the cognitive consequences of traumatic brain injury (TBI). We studied whether the…”
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Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer’s disease by Rinne, J O, Kaasinen, V, Järvenpää, T, Någren, K, Roivainen, A, Yu, M, Oikonen, V, Kurki, T

“…Objective: Brain acetylcholinesterase activity was determined in healthy controls and in patients with mild cognitive impairment and early Alzheimer’s disease…”
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Kinetic modeling of [(18)F]FDG in skeletal muscle by PET: a four-compartment five-rate-constant model by Bertoldo, A, Peltoniemi, P, Oikonen, V, Knuuti, J, Nuutila, P, Cobelli, C

“…Various modeling strategies have been developed to convert regional [(18)F]fluorodeoxyglucose ([(18)F]FDG) concentration measured by positron emission…”
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Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson's disease by KAASINEN, V, NAGREN, K, HIETALA, J, OIKONEN, V, VILKMAN, H, FARDE, L, HALLDIN, C, RINNE, J. O

“…To investigate whether dopamine D2 and D3 receptor subtypes (D2/3Rs) outside the caudate-putamen are affected in PD. Alterations in striatal D2-like dopamine…”
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Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver by IOZZO, P, LAUTAMAKI, R, GEISLER, F, VIRTANEN, K. A, OIKONEN, V, HAAPARANTA, M, YKI-JARVINEN, H, FERRANNINI, E, KNUUTI, J, NUUTILA, P

“…We investigated the effect of elevated circulating NEFA on insulin-mediated hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy…”
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Exercise Restores Skeletal Muscle Glucose Delivery But Not Insulin-Mediated Glucose Transport and Phosphorylation in Obese Subjects by Slimani, L., Oikonen, V., Hällsten, K., Savisto, N., Knuuti, J., Nuutila, P., Iozzo, P.

“…Context/Objective: Insulin resistance in obese subjects results in the impaired disposal of glucose by skeletal muscle. The current study examined the effects…”
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Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and [carbonyl-11C]WAY-100635—considerations on the validity of cerebellum as a reference region by Hirvonen, Jussi, Kajander, J., Allonen, T., Oikonen, V., Någren, K., Hietala, J.

“…Background: The selective and potent radioligand [carbonyl-11C]WAY-100635 provides a useful tool for the in vivo measurement of 5-HT1A receptor binding with…”
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[11C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: Correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology by LAMUSUO, S, PITKÄNEN, A, VAPALAHTI, M, VAINIO, P, RINNE, J. O, JUTILA, L, YLINEN, A, PARTANEN, K, KÄLVIÄINEN, R, RUOTTINEN, H.-M, OIKONEN, V, NAGREN, K, LEHIKOINEN, P

“…To detect reduced [11C]flumazenil in patients with temporal lobe epilepsy (TLE) and to relate binding to histopathology. The authors studied 16 patients who…”
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Striatal uptake of a novel PET ligand, [18F]β-CFT, is reduced in early Parkinson's disease by Rinne, J.O., Bergman, J., Ruottinen, H., Haaparanta, M., Eronen, E., Oikonen, V., Sonninen, P., Solin, O.

“…[18F]β‐CFT is a novel PET ligand for dopamine reuptake sites. In this study, [18F]β‐CFT uptake was studied in nine patients with early Parkinson's disease (PD)…”
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[18F]fluorodopa PET shows striatal dopaminergic dysfunction in juvenile neuronal ceroid lipofuscinosis by Ruottinen, H M, Rinne, J O, Haaparanta, M, Solin, O, Bergman, J, Oikonen, V J, Järvelä, I, Santavuori, P

“…OBJECTIVES: To investigate whether nigrostriatal dopaminergic hypofunction is related to the extrapyramidal symptoms in patients with juvenile neuronal ceroid…”
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Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin by Orava, Janne, Nuutila, Pirjo, Lidell, Martin E., Oikonen, Vesa, Noponen, Tommi, Viljanen, Tapio, Scheinin, Mika, Taittonen, Markku, Niemi, Tarja, Enerbäck, Sven, Virtanen, Kirsi A.

“…We investigated the metabolism of human brown adipose tissue (BAT) in healthy subjects by determining its cold-induced and insulin-stimulated glucose uptake…”
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Evidence for dissociation of insulin stimulation of blood flow and glucose uptake in human skeletal muscle: studies using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and positron emission tomography by Raitakari, M., Nuutila, P., Ruotsalainen, U., Laine, H., Teras, M., Iida, H., Makimattila, S., Utriainen, T., Oikonen, V., Sipila, H., Haaparanta, M., Solin, O., Wegelius, U., Knuuti, J., Yki-Jarvinen, H.

“…Evidence for dissociation of insulin stimulation of blood flow and glucose uptake in human skeletal muscle: studies using [15O]H2O,…”
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Human Bone Marrow Adipose Tissue is a Metabolically Active and Insulin-Sensitive Distinct Fat Depot by Pham, Tam T, Ivaska, Kaisa K, Hannukainen, Jarna C, Virtanen, Kirsi A, Lidell, Martin E, Enerbäck, Sven, Mäkelä, Keijo, Parkkola, Riitta, Piirola, Sauli, Oikonen, Vesa, Nuutila, Pirjo, Kiviranta, Riku

“…Abstract Context Bone marrow (BM) in adult long bones is rich in adipose tissue, but the functions of BM adipocytes are largely unknown. We set out to…”
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PET studies on brain monoamine transporters with carbon-11-β-CIT in Parkinson's disease by LAIHINEN, A. O, RINNE, J. O, NAGREN, K. A, LEHIKOINEN, P. K, OIKONEN, V. J, RUOTSALAINEN, U. H, RUOTTINEN, H. M, RINNE, U. K

“…The cocaine analog 2 beta-carbomethoxy-3 beta-[4-iodophenyl]tropane (beta-CIT) labeled with 11C was used to study dopamine reuptake sites with PET. Three…”
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Impact of metabolic substrate modification on myocardial efficiency in a rat model of obesity and diabetes by Virta, J, M U Silvola, J, Kiugel, M, Liljenback, H, Berglund, L M, Garcia-Vaz, E, Dutius Andersson, A M, Zetterqvist, A, Oikonen, V, Jauhianen, M, Knuuti, J, Nuutila, P, Roivainen, A, F Gomez, M, Saraste, A

“…Abstract Background Congenic leptin receptor deficient rat generated by introgression of the Koletsky leptin receptor mutation into BioBreeding Diabetes…”
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[11C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue by Sun, Lihua, Aarnio, Richard, Herre, Erika Atencio, Kärnä, Salli, Palani, Senthil, Virtanen, Helena, Liljenbäck, Heidi, Virta, Jenni, Honkaniemi, Aake, Oikonen, Vesa, Han, Chunlei, Laurila, Sanna, Bucci, Marco, Helin, Semi, Yatkin, Emrah, Nummenmaa, Lauri, Nuutila, Pirjo, Tang, Jing, Roivainen, Anne

“…Purpose Photoperiod determines the metabolic activity of brown adipose tissue (BAT) and affects the food intake and body mass of mammals. Sympathetic…”
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Quantification of the purinergic P2X7 receptor with [11C]SMW139 improves through correction for brain-penetrating radiometabolites by Brumberg, Joachim, Aarnio, Richard, Forsberg, Anton, Marjamäki, Päivi, Kerstens, Vera, Moein, Mohammad M, Nag, Sangram, Wahlroos, Saara, Kassiou, Michael, Windhorst, Albert D, Halldin, Christer, Haaparanta-Solin, Merja, Fazio, Patrik, Oikonen, Vesa, Rinne, Juha O, Varrone, Andrea

“…The membrane-based purinergic 7 receptor (P2X7R) is expressed on activated microglia and the target of the radioligand [11C]SMW139 for in vivo assessment of…”
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