Search Results - "Oikawa, Ichiro"

Effect of single and multiple doses of elobixibat, an ileal bile acid transporter inhibitor, on chronic constipation: A randomized controlled trial by Kumagai, Yuji, Amano, Hideki, Sasaki, Yoshinobu, Nakagawa, Chie, Maeda, Mika, Oikawa, Ichiro, Furuie, Hidetoshi

“…Aims Elobixibat is a minimally absorbed ileal bile acid transporter inhibitor. This study aimed to investigate the safety, tolerability, efficacy,…”
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Appraisal of ICH E14/S7B Q&As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects by Kambayashi, Ryuichi, Goto, Ai, Izumi-Nakaseko, Hiroko, Oikawa, Ichiro, Ikeda, Naoki, Matsuda, Kazuki, Takei, Yoshinori, Matsumoto, Akio, Kumagai, Yuji, Sugiyama, Atsushi

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Efficacy and safety of once-monthly risedronate in osteoporosis subjects with mild-to-moderate chronic kidney disease: a post hoc subgroup analysis of a phase III trial in Japan by Sugimoto, Toshitsugu, Inoue, Daisuke, Maehara, Masayuki, Oikawa, Ichiro, Shigematsu, Takashi, Nishizawa, Yoshiki

“…Limited data are available on the safety and efficacy of anti-resorptive agents, particularly once-monthly bisphosphonates, for use in osteoporotic patients…”
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Cadence-Based Pedometer App With Financial Incentives to Enhance Moderate-to-Vigorous Physical Activity: Development and Single-Arm Feasibility Study by Hayashi, Kosuke, Imai, Hiromitsu, Oikawa, Ichiro, Ishihara, Yugo, Wakuda, Hirokazu, Miura, Iori, Uenohara, Shingo, Kuwae, Asuka, Kai, Megumi, Furuya, Ken'ichi, Uemura, Naoto

“…High levels of physical activity are key to improving health outcomes, yet many people fail to take action. Using pedometers to target steps per day and…”
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Efficacy and safety of nateglinide plus sitagliptin combination therapy in type 2 diabetes patients inadequately controlled by sitagliptin monotherapy: a phase 3, multicenter, open-label, long-term study by Hirose, Takahisa, Saitoh, Chihiro, Oikawa, Ichiro, Kondo, Nobuo

“…Background Combination therapies of drugs with distinct mechanisms of action are emerging as ways to achieve strict glycemic control, thus preventing the onset…”
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Effects of rifampicin on the pharmacokinetics and safety of carotegrast methyl in healthy subjects: A randomized 2 × 2 crossover study by Imai, Hiromitsu, Oikawa, Ichiro, Koyama, Tetsuya, Matsuki, Shunji

“…Aims To evaluate the effect of the combination of carotegrast methyl with rifampicin, a potent inhibitor of organic anion transporter polypeptide, on the…”
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Evaluation of the potential drug–drug interactions of carotegrast methyl with midazolam, prednisolone or atorvastatin in healthy adults by Matsuki, Shunji, Oikawa, Ichiro, Koyama, Tetsuya, Imai, Hiromitsu

“…Aims This study evaluated drug–drug interactions between the CYP3A4 inhibitor carotegrast methyl and the other CYP3A4 substrates, midazolam, atorvastatin and…”
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Assessing Immunogenicity in Drug Reviews and Prescribing Information in Japan by Ishibai, Mitsuru, Kai, Megumi, Wakuda, Hirokazu, Oikawa, Ichiro, Uemura, Naoto

“…Anti-drug antibodies (ADAs) generated in response to biopharmaceuticals can significantly impact pharmacokinetics (PK) and overall drug efficacy. Thus, the ICH…”
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AJM300, a novel oral antagonist of α4‐integrin, sustains an increase in circulating lymphocytes: A randomised controlled trial in healthy male subjects by Fukase, Hiroyuki, Kajioka, Toshifumi, Oikawa, Ichiro, Ikeda, Naoki, Furuie, Hidetoshi

“…Aims AJM300 is an oral antagonist of α4‐integrin that reduces inflammation by blocking leucocyte trafficking. This study aimed to investigate safety,…”
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Flecainide Toxicity From Clinical Pharmacology Perspectives by Otani, Naoyuki, Wakuda, Hirokazu, Oikawa, Ichiro, Uemura, Naoto, Yasu, Takanori

“…We report a case comparing the measured half-life of flecainide with the half-life stated on the label. An 84-year-old woman presented with symptoms of…”
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Food Effect on a Single High Dose of Carotegrast Methyl, an Oral Antagonist of α4-Integrin, in Healthy Male Subjects: A Randomised, Placebo-Controlled, Double-Blind Study by Fukase, Hiroyuki, Kajioka, Toshifumi, Oikawa, Ichiro, Ikeda, Naoki, Furuie, Hidetoshi

“…Background and Objectives Carotegrast methyl, a novel prodrug, oral antagonist of α4-integrin, is in development for the treatment of active ulcerative…”
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Appraisal of ICH E14/S7B Q As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects by Ryuichi Kambayashi, Ai Goto, Hiroko Izumi-Nakaseko, Ichiro Oikawa, Naoki Ikeda, Kazuki Matsuda, Yoshinori Takei, Akio Matsumoto, Yuji Kumagai, Atsushi Sugiyama

“…We investigated how a lack of placebo control affects the interpretation of results of thorough QT/QTc (TQT) study. Results of TQT study in 48 healthy Japanese…”
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An updated review of gastric cancer in the next-generation sequencing era:Insights from bench to bedside and vice versa by Yamamoto, Hiroyuki, Watanabe, Yoshiyuki, Maehata, Tadateru, Morita, Ryo, Yoshida, Yoshihito, Oikawa, Ritsuko, Ishigooka, Shinya, Ozawa, Shun-Ichiro, Matsuo, Yasumasa, Hosoya, Kosuke, Yamashita, Masaki, Taniguchi, Hiroaki, Nosho, Katsuhiko, Suzuki, Hiromu, Yasuda, Hiroshi, Shinomura, Yasuhisa, Itoh, Fumio

“…Gastric cancer(GC)is one of the most common malignancies and remains the second leading cause of cancer-related death worldwide.There is an increasing…”
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