Search Results - "Oikarinen, Lasse"

Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses by Sánez Tähtisalo, Heini, Ruotsalainen, Sanni, Mars, Nina, Porthan, Kimmo, Oikarinen, Lasse, Virolainen, Juha, Fyhrquist, Frej, Ripatti, Samuli, Kontula, Kimmo K., Hiltunen, Timo P.

“…Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of…”
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Relationship Between Testosterone Level and Early Repolarization on 12-Lead Electrocardiograms in Men by Junttila, M. Juhani, MD, Tikkanen, Jani T., MD, Porthan, Kimmo, MD, Oikarinen, Lasse, MD, Jula, Antti, MD, Kenttä, Tuomas, PhD, Salomaa, Veikko, MD, Huikuri, Heikki V., MD

“…After ECG analysis for all 2,755 male subjects in the study (mean age, 51 ± 14 years), serum testosterone levels were determined with an Architect ci8200…”
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Effect of four classes of antihypertensive drugs on cardiac repolarization heterogeneity: A double-blind rotational study by Sánez Tähtisalo, Heini, Hiltunen, Timo P, Kenttä, Tuomas, Junttila, Juhani, Oikarinen, Lasse, Virolainen, Juha, Kontula, Kimmo K, Porthan, Kimmo

“…T-wave area dispersion (TW-Ad) is a novel electrocardiographic (ECG) repolarization marker associated with sudden cardiac death. However, limited data is…”
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Prediction of sudden cardiac death with automated high-throughput analysis of heterogeneity in standard resting 12-lead electrocardiograms by Kenttä, Tuomas V., PhD, Nearing, Bruce D., PhD, Porthan, Kimmo, MD, PhD, Tikkanen, Jani T., MD, PhD, Viitasalo, Matti, MD, PhD, Nieminen, Markku S., MD, PhD, Salomaa, Veikko, MD, PhD, Oikarinen, Lasse, MD, PhD, Jula, Antti, MD, PhD, Kontula, Kimmo, MD, PhD, Newton-Cheh, Chris, PhD, Huikuri, Heikki V., MD, PhD, Verrier, Richard L., PhD, FHRS

“…Background Heterogeneity of depolarization and repolarization underlies the development of lethal arrhythmias. Objective We investigated whether quantification…”
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Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients by Rimpelä, Jenni M, Pörsti, Ilkka H, Jula, Antti, Lehtimäki, Terho, Niiranen, Teemu J, Oikarinen, Lasse, Porthan, Kimmo, Tikkakoski, Antti, Virolainen, Juha, Kontula, Kimmo K, Hiltunen, Timo P

“…Reduced nocturnal fall (non-dipping) of blood pressure (BP) is a predictor of cardiovascular target organ damage. No genome-wide association studies (GWAS) on…”
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A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern by Sinner, Moritz F., MD, MPH, Porthan, Kimmo, MD, PhD, Noseworthy, Peter A., MD, Havulinna, Aki S., DSc(tech), Tikkanen, Jani T., MD, Müller-Nurasyid, Martina, PhD, Peloso, Gina, PhD, Ulivi, Sheila, PhD, Beckmann, Britt Maria, MD, Brockhaus, A. Catharina, MSc, Cooper, Rebecca R., MA, Gasparini, Paolo, MD, Hengstenberg, Christian, MD, Hwang, Shih-Jen, PhD, Iorio, Annamaria, MD, Junttila, M. Juhani, MD, Klopp, Norman, PhD, Kähönen, Mika, MD, PhD, Laaksonen, Maarit A., PhD, Lehtimäki, Terho, MD, PhD, Lichtner, Peter, PhD, Lyytikäinen, Leo-Pekka, MD, Martens, Eimo, MD, Meisinger, Christa, MD, Meitinger, Thomas, MD, MSc, Merchant, Faisal M., MD, Nieminen, Markku S., MD, Peters, Annette, PhD, Pietilä, Arto, MSc, Perz, Siegfried, MSc, Oikarinen, Lasse, MD, PhD, Raitakari, Olli, MD, PhD, Reinhard, Wibke, MD, MBA, Silander, Kaisa, PhD, Thorand, Barbara, PhD, MPH, Wichmann, H.-Erich, MD, PhD, Sinagra, Gianfranco, MD, Viikari, Jorma, MD, PhD, O'Donnell, Christopher J., MD, MPH, Ellinor, Patrick T., MD, PhD, Huikuri, Heikki V., MD, Kääb, Stefan, MD, PhD, Newton-Cheh, Christopher, MD, MPH, Salomaa, Veikko, MD, PhD

“…Background The early repolarization pattern (ERP) is common and associated with risk of sudden cardiac death. ERP is heritable, and mutations have been…”
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Population-prevalent desmosomal mutations predisposing to arrhythmogenic right ventricular cardiomyopathy by Lahtinen, Annukka M., MSc, Lehtonen, Eero, MD, PhD, Marjamaa, Annukka, MD, PhD, Kaartinen, Maija, MD, PhD, Heliö, Tiina, MD, PhD, Porthan, Kimmo, MD, Oikarinen, Lasse, MD, PhD, Toivonen, Lauri, MD, PhD, Swan, Heikki, MD, PhD, Jula, Antti, MD, PhD, Peltonen, Leena, MD, PhD, Palotie, Aarno, MD, PhD, Salomaa, Veikko, MD, PhD, Kontula, Kimmo, MD, PhD

“…Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive myocardial disorder caused by mutations of desmosomal cell adhesion…”
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High prevalence of four long QT syndrome founder mutations in the Finnish population by Marjamaa, Annukka, Salomaa, Veikko, Newton-Cheh, Christopher, Porthan, Kimmo, Reunanen, Antti, Karanko, Hannu, Jula, Antti, Lahermo, Päivi, Väänänen, Heikki, Toivonen, Lauri, Swan, Heikki, Viitasalo, Matti, Nieminen, Markku S, Peltonen, Leena, Oikarinen, Lasse, Palotie, Aarno, Kontula, Kimmo

“…Long QT syndrome (LQTS) is an inherited arrhythmia disorder with an estimated prevalence of 0.01%-0.05%. In Finland, four founder mutations constitute up to…”
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Common Genetic Variants, QT Interval, and Sudden Cardiac Death in a Finnish Population-Based Study by Noseworthy, Peter A, Havulinna, Aki S, Porthan, Kimmo, Lahtinen, Annukka M, Jula, Antti, Karhunen, Pekka J, Perola, Markus, Oikarinen, Lasse, Kontula, Kimmo K, Salomaa, Veikko, Newton-Cheh, Christopher

“…BACKGROUND—Although sudden cardiac death (SCD) is heritable, its genetic underpinnings are poorly characterized. The QT interval appears to have a graded…”
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Predictive value of electrocardiographic QT interval and T-wave morphology parameters for all-cause and cardiovascular mortality in a general population sample by Porthan, Kimmo, MD, Viitasalo, Matti, MD, PhD, Jula, Antti, MD, PhD, Reunanen, Antti, MD, PhD, Rapola, Janne, MD, PhD, Väänänen, Heikki, MSc, Nieminen, Markku S., MD, PhD, Toivonen, Lauri, MD, PhD, FHRS, Salomaa, Veikko, MD, PhD, Oikarinen, Lasse, MD, PhD

“…Background The predictive value of ECG QT interval for mortality in the general population has been weak. Only a few population studies on the predictive value…”
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Serial assessment of the electrocardiographic strain pattern for prediction of new-onset heart failure during antihypertensive treatment: the LIFE study by Okin, Peter M., Oikarinen, Lasse, Viitasalo, Matti, Toivonen, Lauri, Kjeldsen, Sverre E., Nieminen, Markku S., Edelman, Jonathan M., Dahlöf, Björn, Devereux, Richard B.

“…Aims Although the presence of the electrocardiographic (ECG) strain pattern has been associated with an increased risk of developing heart failure (HF), the…”
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Reductions in albuminuria and in electrocardiographic left ventricular hypertrophy independently improve prognosis in hypertension: the LIFE Study by Olsen, Michael H, Wachtell, Kristian, Ibsen, Hans, Lindholm, Lars H, Dahlöf, Björn, Devereux, Richard B, Kjeldsen, Sverre E, Oikarinen, Lasse, Okin, Peter M

“…BACKGROUNDIn the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study, reduced urine albumin/creatinine ratio (UACR) as well as regression…”
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Electrocardiographic Strain Pattern and Prediction of Cardiovascular Morbidity and Mortality in Hypertensive Patients by Okin, Peter M, Devereux, Richard B, Nieminen, Markku S, Jern, Sverker, Oikarinen, Lasse, Viitasalo, Matti, Toivonen, Lauri, Kjeldsen, Sverre E, Julius, Stevo, Snapinn, Steven, Dahlöf, Björn

“…The ECG strain pattern of lateral ST depression and T-wave inversion is a marker for left ventricular hypertrophy (LVH) and adverse prognosis in population…”
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U-waves and T-wave peak to T-wave end intervals in patients with catecholaminergic polymorphic ventricular tachycardia, effects of beta-blockers by Viitasalo, Matti, MD, Oikarinen, Lasse, MD, Väänänen, Heikki, DSc, Kontula, Kimmo, MD, Toivonen, Lauri, MD, FHRS, Swan, Heikki, MD

“…Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by risk of polymorphic ventricular tachycardia (pVT) and sudden death…”
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The Early Repolarization Pattern in the General Population by Noseworthy, Peter A., MD, Tikkanen, Jani T., MB, Porthan, Kimmo, MD, Oikarinen, Lasse, MD, PhD, Pietilä, Arto, MSc, Harald, Kennet, MSc, Peloso, Gina M., MA, Merchant, Faisal M., MD, Jula, Antti, MD, PhD, Väänänen, Heikki, Lic Sc, Hwang, Shih-Jen, PhD, O'Donnell, Christopher J., MD, MPH, Salomaa, Veikko, MD, PhD, Newton-Cheh, Christopher, MD, MPH, Huikuri, Heikki V., MD

“…Objectives This study sought to describe the clinical correlates and heritability of the early repolarization pattern (ERP) in 2 large, population-based…”
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Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters by Porthan, Kimmo, MD, Marjamaa, Annukka, MD, PhD, Viitasalo, Matti, MD, PhD, Väänänen, Heikki, Lic Sc (Tech), Jula, Antti, MD, PhD, Toivonen, Lauri, MD, PhD, FHRS, Nieminen, Markku S., MD, PhD, Newton-Cheh, Christopher, MD, MPH, Salomaa, Veikko, MD, PhD, Kontula, Kimmo, MD, PhD, Oikarinen, Lasse, MD, PhD

“…Background Single-nucleotide polymorphisms (SNPs) in genes encoding cardiac ion channels and nitric oxide synthase-1 adaptor protein (NOS1AP) are associated…”
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A common variant near the KCNJ2 gene is associated with T-peak to T-end interval by Marjamaa, Annukka, MD, PhD, Oikarinen, Lasse, MD, PhD, Porthan, Kimmo, MD, PhD, Ripatti, Samuli, PhD, Peloso, Gina, PhD, Noseworthy, Peter A., MD, Viitasalo, Matti, MD, PhD, Nieminen, Markku S., MD, PhD, Toivonen, Lauri, MD, PhD, Kontula, Kimmo, MD, PhD, Peltonen, Leena, MD, PhD, Havulinna, Aki S., DSc(Tech), Jula, Antti, MD, PhD, O'Donnell, Christopher J., MD, MPH, Newton-Cheh, Christopher, MD, MPH, Perola, Markus, MD, PhD, Salomaa, Veikko, MD, PhD

“…Background T-peak to T-end (TPE) interval on the electrocardiogram is a measure of myocardial dispersion of repolarization and is associated with an increased…”
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Relation of QT interval and QT dispersion to echocardiographic left ventricular hypertrophy and geometric pattern in hypertensive patients. The LIFE study by Oikarinen, Lasse, Nieminen, Markku S, Viitasalo, Matti, Toivonen, Lauri, Wachtell, Kristian, Papademetriou, Vasilios, Jern, Sverker, Dahlöf, Björn, Devereux, Richard B, Okin, Peter M

“…OBJECTIVE In hypertensive patients, left ventricular hypertrophy (LVH) predicts increased mortality, in part due to an increased incidence of sudden death…”
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Relationship of the electrocardiographic strain pattern to left ventricular structure and function in hypertensive patients: the LIFE study by Okin, Peter M, Devereux, Richard B, Nieminen, Markku S, Jern, Sverker, Oikarinen, Lasse, Viitasalo, Matti, Toivonen, Lauri, Kjeldsen, Sverre E, Julius, Stevo, Dahlöf, Björn

“…OBJECTIVES This study was designed to assess the relation of electrocardiographic (ECG) strain to increased left ventricular (LV) mass, independent of its…”
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Changing Capacity of Electrocardiographic Ventricular Repolarization in Post-Myocardial Infarction Patients With and Without Nonfatal Cardiac Arrest by Järvenpää, Jere, MD, Oikarinen, Lasse, MD, Korhonen, Petri, MD, Väänänen, Heikki, MSc, Toivonen, Lauri, MD, Viitasalo, Matti, MD

“…Prolonged and labile ventricular repolarization and decreased heart rate variability may be associated with susceptibility to ventricular fibrillation (VF)…”
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