Search Results - "Oien, K. A."

Co-amoxiclav jaundice: clinical and histological features and HLA class II association by O'Donohue, J, Oien, K A, Donaldson, P, Underhill, J, Clare, M, MacSween, R N M, Mills, P R

“…BACKGROUND AND AIMS Jaundice associated with co-amoxiclav has been increasingly recognised. We aimed to characterise its clinical and histological features and…”
Get full text

Hepatic granulomas: a 10 year single centre experience by Gaya, D R, Thorburn, D, Oien, K A, Morris, A J, Stanley, A J

“…Background: Epithelioid granulomas have been reported in 2–15% of unselected liver biopsies, with numerous underlying aetiologies described. However, all UK…”
Get full text

Diagnostic work-up of carcinoma of unknown primary: from immunohistochemistry to molecular profiling by Oien, K A, Dennis, J L

“…Carcinoma of unknown primary (CUP) remains a common and challenging clinical problem. The aim of diagnostic work-up in CUP is to classify as specifically as…”
Get full text

Non-alcoholic steatohepatitis: a common cause of progressive chronic liver injury? by Evans, C D J, Oien, K A, MacSween, R N M, Mills, P R

“…Aim: To investigate the natural history of patients with non-alcoholic steatohepatitis by means of a prospective histological study. Methods: One thousand five…”
Get full text

Drug- not carrier-dependent haematological and biochemical changes in a repeated dose study of cyclosporine encapsulated polyester nano- and micro-particles: Size does not matter by Venkatpurwar, V.P, Rhodes, S, Oien, K.A, Elliott, M.A, Tekwe, C.D, Jørgensen, H.G, Kumar, M.N.V. Ravi

“…Highlights • The particulate delivery allows an increase in dose range without accrual of toxicities. • The altered haematological and biochemical changes are…”
Get full text

Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients by Westra, J. L., Hollema, H., Schaapveld, M., Platteel, I., Oien, K. A., Keith, W. N., Mauritz, R., Peters, G. J., Buys, C. H. C. M., Hofstra, R. M. W., Plukker, J. Th. M.

“…Background: The predictive value of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) expression on long-term survival by influencing…”
Get full text

Factors influencing p53 expression in ovarian cancer as a biomarker of clinical outcome in multicentre studies by DE GRAEFF, P, HALL, J, BROWN, R, VAN DER ZEE, A. G. J, CRIJNS, A. P. G, DE BOCK, G. H, PAUL, J, OIEN, K. A, TEN HOOR, K. A, DE JONG, S, HOLLEMA, H, BARTLETT, J. M. S

“…The prognostic impact of p53 immunostaining in a large series of tumours from epithelial ovarian cancer patients in a two-centre study was analysed. The study…”
Get full text

Loss of MSH2 protein expression is a risk factor in early stage cervical cancer by Nijhuis, E R, Nijman, H W, Oien, K A, Bell, A, ten Hoor, K A, Reesink-Peters, N, Boezen, H M, Hollema, H, van der Zee, A G J

“…Background: Loss of mismatch repair (MMR) gene expression has been associated with fewer metastases and improved prognosis in various tumour types. Aims: To…”
Get full text

Cirrhosis with steatohepatitis after adjuvant tamoxifen by Oien, Karin A, Moffat, David, Curry, Graham W, Dickson, Jeanette, Habeshaw, Tim, Mills, Peter R, MacSween, Roderick NM

“…Oien et al report on two cases of cirrhosis with steatohepatitis, which occurred in patients who received tamoxifen 20 mg daily after surgery for breast cancer…”
Get full text

Frequency of early colorectal cancer in patients undergoing colonoscopy by Smith, G. A., Oien, K. A., O'Dwyer, P. J.

“…Background: Early colorectal cancer is defined as carcinoma limited to the mucosa or submucosa. Up to 20 per cent of all colorectal cancers treated in some…”
Get full text

Hepatocellular carcinoma after long-term tamoxifen therapy by Moffat, D. F., Oien, K. A., Dickson, J., Habeshaw, T., McLellan, D. R.

“…We describe a case of hepatocellular carcinoma (HCC) after long term tamoxifen therapy in a 71-year-old woman. The patient was prescribed tamoxifen for 12…”
Get full text

A tale of two sisters by Gaya, D R, McLay, A L C, Oien, K A, Spooner, R J, Reilly, T G

“…Hereditary haemochromatosis is the most common inherited disorder in white populations, whereas non-alcoholic steatohepatitis (NASH) is becoming the most…”
Get full text

Polymorphisms of the renin-angiotensin system and the severity of fibrosis in chronic hepatitis C virus infection by Forrest, E. H., Thorburn, D., Spence, E., Oien, K. A., Inglis, G., Smith, C.-A., McCruden, E. A. B., Fox, R., Mills, P. R.

“…Patients with chronic hepatitis C virus (HCV) infection vary in their rates of fibrosis progression. The renin–angiotensin system (RAS) regulates fibrosis…”
Get full text

Attitudes and training of research fellows in surgery: national questionnaire survey by Seow, Choon S, Teo, Nee B, Wilson, Christopher R, Oien, Karin A

“…In total, 64% (58/91; 95% confidence interval 53% to 74%) of the research fellows were experienced senior house officers before carrying out their research;…”
Get full text

Iron-induced oesophageal injury and pigmentation by Nandini, C L, Lindop, G B, Gillen, D, Hendry, A, Oien, K A

Get full text

Improvement in cholestasis associated with total parenteral nutrition after treatment with an antibody against tumour necrosis factor alpha by Forrest, Ewan H., Oien, K. A., Dickson, S., Galloway, D., Mills, P. R.

“…:  Background: Many patients receiving long‐term total parenteral nutrition (TPN) develop liver disease; cholestasis is common and may be severe. Antitumour…”
Get full text

Pneumocystis carinii pneumonia in a patient with rheumatoid arthritis, not on immunosuppressive therapy and in the absence of human immunodeficiency virus infection by Oien, K A, Black, A, Hunter, J A, Madhok, R

Get more information

Time for change: a new training programme for morpho-molecular pathologists? by Moore, David A, Young, Caroline A, Morris, Hayley T, Oien, Karin A, Lee, Jessica L, Jones, J Louise, Salto-Tellez, Manuel

“…The evolution of cellular pathology as a specialty has always been driven by technological developments and the clinical relevance of incorporating novel…”
Get more information

Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation by Oien, Karin A, McGregor, Fiona, Butler, Sharlene, Ferrier, Rod K, Downie, Ian, Bryce, Steven, Burns, Sharon, Keith, W Nicol

“…Through previous large‐scale gene expression profiling we identified a transcript that was abundant in normal stomach and down‐regulated in gastric cancer…”
Get full text

Demethylation of the MCJ gene in stage III/IV epithelial ovarian cancer and response to chemotherapy by Strathdee, Gordon, Vass, J. Keith, Oien, Karin A., Siddiqui, Nadeem, Curto-Garcia, Jorge, Brown, Robert

“…Methylation of a CpG island within the Methylation controlled DNAJ ( MCJ) gene results in loss of expression in normal and neoplastic cells. Normal ovarian…”
Get full text