Search Results - "Ohwada, Jun"

Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802) by Kinoshita, Kazutomo, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Miyagi, Takuho, Kobayashi, Takamitsu, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

“…Anaplastic lymphoma kinase (ALK) receptor tyrosine kinase is considered an attractive therapeutic target for human cancers, especially non-small cell lung…”
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Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799 by Ohwada, Jun, Ebiike, Hirosato, Kawada, Hatsuo, Tsukazaki, Masao, Nakamura, Mitsuaki, Miyazaki, Takuya, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Kondoh, Osamu, Kuramoto, Shino, Ogawa, Kotaro, Aoki, Yuko, Shimma, Nobuo

“…An orally available, potent class I PI3K inhibitor, CH5132799, was discovered by structure-based drug design. Phosphatidylinositol 3-kinase (PI3K) is a lipid…”
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In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan by Yamazaki, Toshikazu, Inagaki, Yukiko, Fujii, Toshihiko, Ohwada, Jun, Tsukazaki, Masao, Umeda, Isao, Kobayashi, Kazuko, Shimma, Nobuo, Page, Malcolm G.P, Arisawa, Mikio

“…Abstract The in vitro susceptibilities of 140 laboratory reference strains of fungi, including type strains, and 165 clinical yeast isolates from Japan towards…”
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Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole by Ohwada, Jun, Tsukazaki, Masao, Hayase, Tadakatsu, Oikawa, Nobuhiro, Isshiki, Yoshiaki, Fukuda, Hiroshi, Mizuguchi, Eisaku, Sakaitani, Masahiro, Shiratori, Yasuhiko, Yamazaki, Toshikazu, Ichihara, Shigeyasu, Umeda, Isao, Shimma, Nobuo

“…A highly potent water soluble triazole antifungal prodrug, RO0098557 ( 1), has been identified from its parent, the novel antifungal agent RO0094815 ( 2). The…”
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Synthesis of novel water soluble benzylazolium prodrugs of lipophilic azole antifungals by Ohwada, Jun, Murasaki, Chikako, Yamazaki, Toshikazu, Ichihara, Shigeyasu, Umeda, Isao, Shimma, Nobuo

“…Water soluble N-benzyltriazolium or N-benzylimidazolium salt type prodrugs of several highly lipophilic triazole or imidazole antifungals have been…”
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The Selective Class I PI3K Inhibitor CH5132799 Targets Human Cancers Harboring Oncogenic PIK3CA Mutations by TANAKA, Hiroshi, YOSHIDA, Miyuki, YOSHIMURA, Yasushi, YAMAZAKI, Toshikazu, ISHII, Nobuya, KONDOH, Osamu, AOKI, Yuko, TANIMURA, Hiromi, FUJII, Toshihiko, SAKATA, Kiyoaki, TACHIBANA, Yukako, OHWADA, Jun, EBIIKE, Hirosato, KURAMOTO, Shino, MORITA, Keiichi

“…The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in cell proliferation and survival in human cancer. PIK3CA mutations, which are found in…”
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9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors by Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

“…9-Substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles were discovered as highly selective and potent anaplastic lymphoma kinase (ALK) inhibitors…”
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Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability by Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Yamamoto, Shun, Koyama, Kohei, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shinma, Nobuo, Tsukuda, Takuo, Ohwada, Jun

“…[Display omitted] Phosphoinositide 3-kinase (PI3K) is activated in various human cancer cells and well known as a cancer therapy target. We previously reported…”
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Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors by Chiba, Takashi, Ohwada, Jun, Sakamoto, Hiroshi, Kobayashi, Takamitsu, Fukami, Takaaki A., Irie, Machiko, Miura, Takaaki, Ohara, Kazuhiro, Koyano, Hiroshi

“…We conducted a high throughput screening for glyoxalase I (GLO1) inhibitors and identified 4,6-diphenyl-N-hydroxypyridone as a lead compound. Using a binding…”
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Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents by Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Yamamoto, Shun, Koyama, Kohei, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shimma, Nobuo, Tsukuda, Takuo, Ohwada, Jun

“…[Display omitted] Phosphoinositide 3-kinase (PI3K) is a promising anti-cancer target, because various mutations and amplifications are observed in human tumors…”
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Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation by Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shimma, Nobuo, Tsukuda, Takuo, Ohwada, Jun

“…Based on structure–activity relationship information and a FlexSIS docking simulation score, aminopyrimidine was identified as a bioisostere of metabolically…”
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Abstract B157: Selective class I PI3K inhibitor CH5132799 induces significant tumor regression with suppressing 4E-BP1 phosphorylation by Tanaka, Hiroshi, Yoshida, Miyuki, Tanimura, Hiromi, Ohwada, Jun, Ishii, Nobuya, Kondoh, Osamu, Aoki, Yuko

“…Abstract The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in cell proliferation and survival in human cancer. Mutations of the PIK3CA…”
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SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF A NOVEL ANTIFUNGAL AGENT, AZOXYBACILIN by OHWADA, Jun, UMEDA, Isao, ONTSUKA, Hitomi, AOKI, Yuhko, SHIMMA, Nobuo

“…A new antifungal substance, azoxybacilin (an unusual amino acid with an azoxy moiety) and its derivatives have been synthesized from Boc-L-Asp-OtBu utilizing…”
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9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5 H -benzo[ b ]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors by Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Abstract 3593: Generation of a potent and selective inhibitor of ALK, CH5424802, showing superior oral bioavailability, PK profile and in vivo efficacy by Oikawa, Nobuhiro, Kinoshita, Kazutomo, Asoh, Kohsuke, Furuichi, Noriyuki, Itoh, Toshiya, Kawada, Hatsuo, Hara, Sosuke, Miyagi, Takuho, Ohwada, Jun, Taniguchi, Saori, Hattori, Kazuo, Tsukuda, Takuo, Takanashi, Kenji, Sakamoto, Hiroshi, Tsukaguchi, Toshiyuki, Ishii, Nobuya, Aoki, Yuko, Shimma, Nobuo

“…Abstract Anaplastic lymphoma kinase (ALK) is a tyrosine kinase that is constitutively activated in some cancers, due to gene alterations such as chromosomal…”
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water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts by Endo, Mika, Miwa, Masanori, Ura, Masako, Tanimura, Hiromi, Taniguchi, Kenji, Miyazaki, Yoko, Ohwada, Jun, Tsukazaki, Masao, Niizuma, Satoshi, Murata, Takeshi, Ozawa, Sawako, Suda, Hitomi, Ogawa, Kotaro, Nanba, Eitaro, Nagao, Shunsuke, Shimma, Nobuo, Yamada-Okabe, Hisafumi

“…Purpose Identification of a novel topoisomerase I inhibitor which shows superior efficacy and less individual variation than irinotecan hydrochloride (CPT-11)…”
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Synthesis of new camptothecin analogs with improved antitumor activities by NIIZUMA, Satoshi, TSUKAZAKI, Masao, YOSHINARI, Kiyoshi, ENDO, Mika, URA, Masako, TANIMURA, Hiromi, MIYAZAKI, Yoko, TAKASUKA, Tsuyoshi, KAWASHIMA, Akira, NANBA, Eitaro, NAKANO, Kounosuke, OGAWA, Kotaro, SUDA, Hitomi, KOBAYASHI, Kazuko, OKABE, Hisafumi, UMEDA, Isao, SHIMMA, Nobuo, MURATA, Takeshi, OHWADA, Jun, OZAWA, Sawako, FUKUDA, Hiroshi, MURASAKI, Chikako, KOHCHI, Masami, MORIKAMI, Kenji

“…Novel hexacyclic camptothecin analogs containing cyclic amidine, urea, or thiourea moiety were designed and synthesized based on the proposed 3D-structure of…”
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Synthesis and biological activities of a pH-dependently activated water-soluble prodrug of a novel hexacyclic camptothecin analog by Ohwada, Jun, Ozawa, Sawako, Kohchi, Masami, Fukuda, Hiroshi, Murasaki, Chikako, Suda, Hitomi, Murata, Takeshi, Niizuma, Satoshi, Tsukazaki, Masao, Ori, Kazutomo, Yoshinari, Kiyoshi, Itezono, Yoshiko, Endo, Mika, Ura, Masako, Tanimura, Hiromi, Miyazaki, Yoko, Kawashima, Akira, Nagao, Shunsuke, Namba, Eitarou, Ogawa, Koutarou, Kobayashi, Kazuko, Okabe, Hisafumi, Umeda, Isao, Shimma, Nobuo

“…A pH-dependently activated water-soluble antitumor prodrug, CH4556300 (TP300, a hydrochloride), was designed and synthesized from a novel hexacyclic…”
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A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts by ENDO, Mika, MIWA, Masanori, OZAWA, Sawako, SUDA, Hitomi, OGAWA, Kotaro, NANBA, Eitaro, NAGAO, Shunsuke, SHIMMA, Nobuo, YAMADA-OKABE, Hisafumi, URA, Masako, TANIMURA, Hiromi, TANIGUCHI, Kenji, MIYAZAKI, Yoko, OHWADA, Jun, TSUKAZAKI, Masao, NIIZUMA, Satoshi, MURATA, Takeshi

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CMOS circuits for peripheral circuit integrated poly-Si TFT LCD fabricated at low temperature below 600°C by TAKABATAKE, M, OHWADA, J.-I, ONO, Y. A, ONO, K, MIMURA, A, KONISHI, N

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