Search Results - "Ohtomo, Natsuko"

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2 by Ikeda, Hitoshi, Watanabe, Naoko, Ishii, Isao, Shimosawa, Tatsuo, Kume, Yukio, Tomiya, Tomoaki, Inoue, Yukiko, Nishikawa, Takako, Ohtomo, Natsuko, Tanoue, Yasushi, Iitsuka, Satoko, Fujita, Ryoto, Omata, Masao, Chun, Jerold, Yatomi, Yutaka

“…Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, stimulates proliferation and contractility in hepatic stellate cells, the principal matrix-producing…”
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Autotaxin as a novel serum marker of liver fibrosis by Nakagawa, Hayato, Ikeda, Hitoshi, Nakamura, Kazuhiro, Ohkawa, Ryunosuke, Masuzaki, Ryota, Tateishi, Ryosuke, Yoshida, Haruhiko, Watanabe, Naoko, Tejima, Kazuaki, Kume, Yukio, Iwai, Tomomi, Suzuki, Atsushi, Tomiya, Tomoaki, Inoue, Yukiko, Nishikawa, Takako, Ohtomo, Natsuko, Tanoue, Yasushi, Omata, Masao, Igarashi, Koji, Aoki, Junken, Koike, Kazuhiko, Yatomi, Yutaka

“…The clinical significance of autotaxin (ATX), a key enzyme for the production of the bioactive lysophospholipid lysophosphatidic acid remains unknown. Serum…”
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Induction of p53-dependent p21 limits proliferative activity of rat hepatocytes in the presence of hepatocyte growth factor by Inoue, Yukiko, Tomiya, Tomoaki, Nishikawa, Takako, Ohtomo, Natsuko, Tanoue, Yasushi, Ikeda, Hitoshi, Koike, Kazuhiko

“…Hepatocyte growth factor (HGF), a potent mitogen for hepatocytes, enhances hepatocyte function without stimulating proliferation, depending on the…”
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Prediction of Hepatocellular Carcinoma Development by Plasma ADAMTS13 in Chronic Hepatitis B and C by IKEDA, Hitoshi, TATEISHI, Ryosuke, TOMIYA, Tomoaki, INOUE, Yukiko, NISHIKAWA, Takako, OHTOMO, Natsuko, TANOUE, Yasushi, ONO, Tomoko, KOIKE, Kazuhiko, YATOMI, Yutaka, ENOOKU, Kenichiro, YOSHIDA, Haruhiko, NAKAGAWA, Hayato, MASUZAKI, Ryota, KONDO, Yuji, GOTO, Tadashi, SHIINA, Shuichiro, KUME, Yukio

“…Chronic liver injury evokes a wound healing response, promoting fibrosis and finally hepatocellular carcinoma (HCC), in which hepatic stellate cells play an…”
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Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats by Ikeda, Hitoshi, Kume, Yukio, Tejima, Kazuaki, Tomiya, Tomoaki, Nishikawa, Takako, Watanabe, Naoko, Ohtomo, Natsuko, Arai, Masahiro, Arai, Chihiro, Omata, Masao, Fujiwara, Kenji, Yatomi, Yutaka

“…A protective effect of Rho-kinase inhibitor on various organ injuries is gaining attention. Regarding liver injury, Rho-kinase inhibitor is reported to prevent…”
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Interaction of α-taxilin Localized on Intracellular Components with the Microtubule Cytoskeleton by Horii, Yukimi, Nogami, Satoru, Kawano, Yoji, Kaneko-Kawano, Takako, Ohtomo, Natsuko, Tomiya, Tomoaki, Shirataki, Hiromichi

“…Intracellular vesicle traffic plays an essential role in the establishment and maintenance of organelle identity and biosynthetic transport. We have identified…”
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Stimulation by glutamine and proline of HGF production in hepatic stellate cells by Nishikawa, Takako, Tomiya, Tomoaki, Ohtomo, Natsuko, Inoue, Yukiko, Ikeda, Hitoshi, Tejima, Kazuaki, Watanabe, Naoko, Tanoue, Yasushi, Omata, Masao, Fujiwara, Kenji

“…Amino acids regulate cellular functions in a variety of cell types. Most notably, leucine stimulates protein production through the mammalian target of…”
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Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells by Tejima, Kazuaki, Arai, Masahiro, Ikeda, Hitoshi, Tomiya, Tomoaki, Yanase, Mikio, Inoue, Yukiko, Nishikawa, Takako, Watanabe, Naoko, Ohtomo, Natsuko, Omata, Masao, Fujiwara, Kenji

“…To elucidate the mechanisms of hepatocyte preconditioning by H2O2 to better understand the pathophysiology of ischemic preconditioning. The in vitro effect of…”
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High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential by Uranbileg, Baasanjav, Enooku, Kenichiro, Soroida, Yoko, Ohkawa, Ryunosuke, Kudo, Yotaro, Nakagawa, Hayato, Tateishi, Ryosuke, Yoshida, Haruhiko, Shinzawa, Seiko, Moriya, Kyoji, Ohtomo, Natsuko, Nishikawa, Takako, Inoue, Yukiko, Tomiya, Tomoaki, Kojima, Soichi, Matsuura, Tomokazu, Koike, Kazuhiko, Yatomi, Yutaka, Ikeda, Hitoshi

“…We previously reported the increased serum mitochondrial creatine kinase (MtCK) activity in patients with hepatocellular carcinoma (HCC), mostly due to the…”
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Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents by Kageyama, Yuko, Ikeda, Hitoshi, Watanabe, Naoko, Nagamine, Masakazu, Kusumoto, Yoshika, Yashiro, Mitsuru, Satoh, Yumiko, Shimosawa, Tatsuo, Shinozaki, Koji, Tomiya, Tomoaki, Inoue, Yukiko, Nishikawa, Takako, Ohtomo, Natsuko, Tanoue, Yasushi, Yokota, Hiromitsu, Koyama, Takatoshi, Ishimaru, Kazuhiro, Okamoto, Yasuo, Takuwa, Yoh, Koike, Kazuhiko, Yatomi, Yutaka

“…Sinusoidal vasoconstriction, in which hepatic stellate cells operate as contractile machinery, has been suggested to play a pivotal role in the pathophysiology…”
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Expression of α-taxilin in the murine gastrointestinal tract: potential implication in cell proliferation by Horii, Yukimi, Sakane, Hiroshi, Nogami, Satoru, Ohtomo, Natsuko, Tomiya, Tomoaki, Shirataki, Hiromichi

“…α-Taxilin, a binding partner of the syntaxin family, is a candidate tumor marker. To gain insight into the physiological role of α-taxilin in normal tissues,…”
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Expression of [alpha]-taxilin in the murine gastrointestinal tract: potential implication in cell proliferation by Horii, Yukimi, Sakane, Hiroshi, Nogami, Satoru, Ohtomo, Natsuko, Tomiya, Tomoaki, Shirataki, Hiromichi

“…[alpha]-Taxilin, a binding partner of the syntaxin family, is a candidate tumor marker. To gain insight into the physiological role of [alpha]-taxilin in…”
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Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C by Ikeda, Hitoshi, Ohkawa, Ryunosuke, Watanabe, Naoko, Nakamura, Kazuhiro, Kume, Yukio, Nakagawa, Hayato, Yoshida, Haruhiko, Okubo, Shigeo, Yokota, Hiromitsu, Tomiya, Tomoaki, Inoue, Yukiko, Nishikawa, Takako, Ohtomo, Natsuko, Tanoue, Yasushi, Koike, Kazuhiko, Yatomi, Yutaka

“…Bioactive lipid mediator S1P has been suggested to play pathophysiological roles in various fields of clinical science as a circulating paracrine mediator. We…”
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Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway by Tomiya, Tomoaki, Nishikawa, Takako, Inoue, Yukiko, Ohtomo, Natsuko, Ikeda, Hitoshi, Tejima, Kazuaki, Watanabe, Naoko, Tanoue, Yasushi, Omata, Masao, Fujiwara, Kenji

“…Branched chain amino acids modulate various cellular functions in addition to providing substrates for the production of proteins. We examined the mechanism…”
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Expression of α-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor by OHTOMO, Natsuko, TOMIYA, Tomoaki, KOIKE, Kazuhiko, SHIRATAKI, Hiromichi, FUJIWARA, Kenji, TANOUE, Yasushi, INOUE, Yukiko, NISHIKAWA, Takako, IKEDA, Hitoshi, SEYAMA, Yasuji, KOKUDO, Norihiro, SHIBAHARA, Junji, FUKAYAMA, Masashi

“…The membrane traffic system has been recognized to be involved in carcinogenesis and tumor progression in several types of tumors. α-taxilin is a newly…”
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Interaction of [alpha]-taxilin Localized on Intracellular Components with the Microtubule Cytoskeleton by Horii, Yukimi, Nogami, Satoru, Kawano, Yoji, Kaneko-Kawano, Takako, Ohtomo, Natsuko, Tomiya, Tomoaki, Shirataki, Hiromichi

“…Intracellular vesicle traffic plays an essential role in the establishment and maintenance of organelle identity and biosynthetic transport. We have identified…”
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Induction of p53-Dependent p21 Limits Proliferative Activity of Rat Hepatocytes in the Presence of Hepatocyte Growth Factor: e78346 by Inoue, Yukiko, Tomiya, Tomoaki, Nishikawa, Takako, Ohtomo, Natsuko, Tanoue, Yasushi, Ikeda, Hitoshi, Koike, Kazuhiko

“…Background Hepatocyte growth factor (HGF), a potent mitogen for hepatocytes, enhances hepatocyte function without stimulating proliferation, depending on the…”
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