Search Results - "Ohtomo, Gaku"

YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology by Tanaka, Hikari, Homma, Hidenori, Fujita, Kyota, Kondo, Kanoh, Yamada, Shingo, Jin, Xiaocen, Waragai, Masaaki, Ohtomo, Gaku, Iwata, Atsushi, Tagawa, Kazuhiko, Atsuta, Naoki, Katsuno, Masahisa, Tomita, Naoki, Furukawa, Katsutoshi, Saito, Yuko, Saito, Takashi, Ichise, Ayaka, Shibata, Shinsuke, Arai, Hiroyuki, Saido, Takaomi, Sudol, Marius, Muramatsu, Shin-ichi, Okano, Hideyuki, Mufson, Elliott J., Sobue, Gen, Murayama, Shigeo, Okazawa, Hitoshi

“…The timing and characteristics of neuronal death in Alzheimer’s disease (AD) remain largely unknown. Here we examine AD mouse models with an original marker,…”
Get full text

Cilostazol alleviates white matter degeneration caused by chronic cerebral hypoperfusion in mice: Implication of its mechanism from gene expression analysis by Ohtomo, Ryo, Bannai, Taro, Ohtomo, Gaku, Shindo, Akihiro, Tomimoto, Hidekazu, Tsuji, Shoji, Iwata, Atsushi

“…•Long-term administration of cilostazol alleviated white matter degeneration caused by chronic cerebral hypoperfusion.•Temporal up-regulation of the genes…”
Get full text

Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight by Bannai, Taro, Mano, Tatsuo, Chen, Xigui, Ohtomo, Gaku, Ohtomo, Ryo, Tsuchida, Takeyuki, Koshi-Mano, Kagari, Hashimoto, Tadafumi, Okazawa, Hitoshi, Iwatsubo, Takeshi, Tsuji, Shoji, Toda, Tatsushi, Iwata, Atsushi

“…Epidemiological studies have shown that atherosclerotic risk factors accelerate the pathological process underlying Alzheimer’s disease (AD) via chronic…”
Get full text

Proteomic profile of nuclei containing p62-positive inclusions in a patient with neuronal intranuclear inclusion disease by Kurihara, Masanori, Mano, Tatsuo, Eto, Fumihiro, Yao, Ikuko, Sato, Kenichiro, Ohtomo, Gaku, Bannai, Taro, Shibata, Shota, Ishiura, Hiroyuki, Ikemura, Masako, Matsubara, Tomoyasu, Morishima, Maho, Saito, Yuko, Murayama, Shigeo, Toda, Tatsushi, Setou, Mitsutoshi, Iwata, Atsushi

“…Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease characterized by eosinophilic hyaline intranuclear inclusions in the neurons,…”
Get full text

Degeneration of the Substantia Nigra Following Ipsilateral Striatal Infarction by Ohtomo, Gaku, Mano, Tatsuo, Seto, Akiko, Tsuji, Shoji

Get full text

Treadmill Exercise During Cerebral Hypoperfusion Has Only Limited Effects on Cognitive Function in Middle-Aged Subcortical Ischemic Vascular Dementia Mice by Ohtomo, Ryo, Ishikawa, Hidehiro, Kinoshita, Keita, Chung, Kelly K, Hamanaka, Gen, Ohtomo, Gaku, Takase, Hajime, Wrann, Christiane D, Katsuki, Hiroshi, Iwata, Atsushi, Lok, Josephine, Lo, Eng H, Arai, Ken

“…Clinical and basic research suggests that exercise is a safe behavioral intervention and is effective for improving cognitive function in cerebrovascular…”
Get full text

Lambert‐Eaton myasthenic syndrome with anti‐acetylcholine receptor antibody and anterior mediastinal tumor by Matsumoto, Hideyuki, Ohtomo, Gaku, Akahori, Tsugumi, Hashida, Hideji

“…This report describes the case of a 65‐year‐old male who complained of muscular weakness of the legs with easy fatigability. Blood and imaging examinations…”
Get full text

DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis by Homma, Hidenori, Tanaka, Hikari, Jin, Meihua, Jin, Xiaocen, Huang, Yong, Yoshioka, Yuki, Bertens, Christian JF, Tsumaki, Kohei, Kondo, Kanoh, Shiwaku, Hiroki, Tagawa, Kazuhiko, Akatsu, Hiroyasu, Atsuta, Naoki, Katsuno, Masahisa, Furukawa, Katsutoshi, Ishiki, Aiko, Waragai, Masaaki, Ohtomo, Gaku, Iwata, Atsushi, Yokota, Takanori, Inoue, Haruhisa, Arai, Hiroyuki, Sobue, Gen, Sone, Masaki, Fujita, Kyota, Okazawa, Hitoshi

“…The early-stage pathologies of frontotemporal lobal degeneration (FTLD) remain largely unknown. In VCP T262A -KI mice carrying VCP gene mutation linked to…”
Get full text

Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion by Ohtomo, Ryo, Kinoshita, Keita, Ohtomo, Gaku, Takase, Hajime, Hamanaka, Gen, Washida, Kazuo, Islam, Mohammad Rashedul, Wrann, Christiane D., Katsuki, Hiroshi, Iwata, Atsushi, Lok, Josephine, Lo, Eng H., Arai, Ken

Get full text

P2‐070: CHRONIC CEREBRAL HYPOPERFUSION INCREASES AMYLOID PLAQUES BY ACCELERATING AMYLOID BETA AGGREGATION IN APP/PS1 TRANSGENIC MICE by Bannai, Taro, Iwata, Atsushi, Mano, Tatsuo, Ohtomo, Ryo, Ohtomo, Gaku, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Toda, Tatsushi

Get full text

CHRONIC CEREBRAL HYPOPERFUSION INCREASES AMYLOID PLAQUES BY ACCELERATING AMYLOID BETA AGGREGATION IN APP/PS1 TRANSGENIC MICE by Bannai, Taro, Iwata, Atsushi, Mano, Tatsuo, Ohtomo, Ryo, Ohtomo, Gaku, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Toda, Tatsushi

Get full text

Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion by Ohtomo, Ryo, Kinoshita, Keita, Ohtomo, Gaku, Takase, Hajime, Hamanaka, Gen, Washida, Kazuo, Islam, Mohammad Rashedul, Wrann, Christiane D., Katsuki, Hiroshi, Iwata, Atsushi, Lok, Josephine, Lo, Eng H., Arai, Ken

“…Clinical evidence suggests that patients with subcortical ischemic vascular dementia (SIVD) perform better at cognitive tests after exercise. However, the…”
Get full text