Search Results - "Ohte, Yuki"
-
1
Specific Modification of Aged Proteasomes Revealed by Tag-Exchangeable Knock-In Mice
Published in Molecular and cellular biology (01-01-2019)“…The proteasome is the proteolytic machinery at the center of regulated intracellular protein degradation and participates in various cellular processes…”
Get full text
Journal Article -
2
In-depth Analysis of the Lid Subunits Assembly Mechanism in Mammals
Published in Biomolecules (Basel, Switzerland) (31-05-2019)“…The 26S proteasome is a key player in the degradation of ubiquitinated proteins, comprising a 20S core particle (CP) and a 19S regulatory particle (RP). The RP…”
Get full text
Journal Article -
3
Assembly mechanisms of specialized core particles of the proteasome
Published in Biomolecules (Basel, Switzerland) (16-07-2014)“…The 26S proteasome has a highly complicated structure comprising the 20S core particle (CP) and the 19S regulatory particle (RP). Along with the standard CP in…”
Get full text
Journal Article -
4
Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells
Published in Nature communications (23-06-2015)“…Positive selection in the thymus provides low-affinity T-cell receptor (TCR) engagement to support the development of potentially useful self-major…”
Get full text
Journal Article -
5
The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells
Published in EMBO reports (01-05-2015)“…The thymus provides a specialized microenvironment in which distinct subsets of thymic epithelial cells (TECs) support T‐cell development. Here, we describe…”
Get full text
Journal Article -
6
The thymic cortical epithelium determines the TCR repertoire of IL-17-producing [gamma][delta]T cells
Published in EMBO reports (01-05-2015)“…The thymus provides a specialized microenvironment in which distinct subsets of thymic epithelial cells (TECs) support T-cell development. Here, we describe…”
Get full text
Journal Article -
7
A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production
Published in JCI insight (18-05-2017)“…The Psmb11-encoded β5t subunit of the thymoproteasome, which is specifically expressed in cortical thymic epithelial cells (cTECs), is essential for the…”
Get full text
Journal Article