Search Results - "Ohtake, Yosuke"

Molecular mechanisms of scar-sourced axon growth inhibitors by Ohtake, Yosuke, Li, Shuxin

“…Abstract Astrogliosis is a defense response of the CNS to minimize primary damage and to repair injured tissues, but it ultimately generates harmful effects by…”
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ER Stress and Disease: Toward Prevention and Treatment by Kaneko, Masayuki, Imaizumi, Kazunori, Saito, Atsushi, Kanemoto, Soshi, Asada, Rie, Matsuhisa, Koji, Ohtake, Yosuke

“…Secretory and membrane proteins are synthesized in ribosomes, then mature in the endoplasmic reticulum (ER), but if ER function is impaired, immature defective…”
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Diverse functions of protein tyrosine phosphatase σ in the nervous and immune systems by Ohtake, Yosuke, Saito, Atsushi, Li, Shuxin

“…Tyrosine phosphorylation is a common means of regulating protein functions and signal transduction in multiple cells. Protein tyrosine phosphatases (PTPs) are…”
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Immunotherapies in Huntington's disease and α-Synucleinopathies by Fatoba, Oluwaseun, Ohtake, Yosuke, Itokazu, Takahide, Yamashita, Toshihide

“…Modulation of immune activation using immunotherapy has attracted considerable attention for many years as a potential therapeutic intervention for several…”
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Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity by Ando, Kanae, Maruko-Otake, Akiko, Ohtake, Yosuke, Hayashishita, Motoki, Sekiya, Michiko, Iijima, Koichi M

“…Abnormal accumulation of the microtubule-interacting protein tau is associated with neurodegenerative diseases including Alzheimer's disease (AD). β-amyloid…”
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PTEN inhibition and axon regeneration and neural repair by Ohtake, Yosuke, Hayat, Umar, Li, Shuxin

“…The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling…”
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Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy by Oka, Mikiko, Fujisaki, Naoki, Maruko-Otake, Akiko, Ohtake, Yosuke, Shimizu, Sawako, Saito, Taro, Hisanaga, Shin-Ichi, Iijima, Koichi M, Ando, Kanae

“…Abnormal deposition of the microtubule-associated protein tau is a common pathological feature of multiple neurodegenerative diseases, including Alzheimer's…”
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Neuronal activity‐dependent local activation of dendritic unfolded protein response promotes expression of brain‐derived neurotrophic factor in cell soma by Saito, Atsushi, Cai, Longjie, Matsuhisa, Koji, Ohtake, Yosuke, Kaneko, Masayuki, Kanemoto, Soshi, Asada, Rie, Imaizumi, Kazunori

“…Unfolded protein response (UPR) has roles not only in resolving the accumulation of unfolded proteins owing to endoplasmic reticulum (ER) stress, but also in…”
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Glial senescence enhances α-synuclein pathology owing to its insufficient clearance caused by autophagy dysfunction by Hong, Bin, Ohtake, Yosuke, Itokazu, Takahide, Yamashita, Toshihide

“…Parkinson’s disease (PD) is characterized by the pathological accumulation of α-synuclein (α-syn) and loss of dopaminergic neurons in the substantia nigra…”
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Two PTP receptors mediate CSPG inhibition by convergent and divergent signaling pathways in neurons by Ohtake, Yosuke, Wong, Daniella, Abdul-Muneer, P. M., Selzer, Michael E., Li, Shuxin

“…Receptor protein tyrosine phosphatase σ (PTPσ) and its subfamily member LAR act as transmembrane receptors that mediate growth inhibition of chondroitin…”
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Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1 by Iijima-Ando, Kanae, Sekiya, Michiko, Maruko-Otake, Akiko, Ohtake, Yosuke, Suzuki, Emiko, Lu, Bingwei, Iijima, Koichi M

“…Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved in the pathogenesis of Alzheimer's disease (AD); however, what…”
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Promoting Axon Regeneration in Adult CNS by Targeting Liver Kinase B1 by Ohtake, Yosuke, Sami, Armin, Jiang, Xinpei, Horiuchi, Makoto, Slattery, Kieran, Ma, Lena, Smith, George M., Selzer, Michael E., Muramatsu, Shin-ichi, Li, Shuxin

“…Liver kinase B1 (LKB1), a downstream effector of cyclic AMP (cAMP)/PKA and phosphatidylinositol 3-kinase (PI3K) pathways, is a determinant for migration and…”
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The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury by Ohtake, Yosuke, Park, Dongsun, Abdul-Muneer, P.M, Li, Hui, Xu, Bin, Sharma, Kartavya, Smith, George M, Selzer, Michael E, Li, Shuxin

“…Abstract Knockout studies suggest that PTEN limits the regenerative capacities of CNS axons as a dominant antagonist of PI3 kinase, but the transgenic approach…”
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Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated by Ando, Kanae, Oka, Mikiko, Ohtake, Yosuke, Hayashishita, Motoki, Shimizu, Sawako, Hisanaga, Shin-ichi, Iijima, Koichi M.

“…Abnormal phosphorylation of the microtubule-associated protein tau is observed in many neurodegenerative diseases, including Alzheimer's disease (AD)…”
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Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury by Ohtake, Yosuke, Matsuhisa, Koji, Kaneko, Masayuki, Kanemoto, Soshi, Asada, Rie, Imaizumi, Kazunori, Saito, Atsushi

“…•Ca2+ release from ER induced by peripheral nerve injury promotes axonal UPR activation.•Injury-induced axonal activation of UPR branches contributes to…”
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Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury by Xu, Bin, Park, Dongsun, Ohtake, Yosuke, Li, Hui, Hayat, Umar, Liu, Junjun, Selzer, Michael E, Longo, Frank M, Li, Shuxin

“…Abstract Extracellular matrix molecule chondroitin sulfate proteoglycans (CSPGs) are highly upregulated in scar tissues and form a potent chemical barrier for…”
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Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183 by Wu, Yan, Guo, Xiao Peng, Kanemoto, Soshi, Maeoka, Yujiro, Saito, Atsushi, Asada, Rie, Matsuhisa, Koji, Ohtake, Yosuke, Imaizumi, Kazunori, Kaneko, Masayuki

“…We identified 37 ubiquitin ligases containing RING-finger and transmembrane domains. Of these, we found that RNF183 is abundantly expressed in the kidney…”
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S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy by Chiku, Tomoki, Hayashishita, Motoki, Saito, Taro, Oka, Mikiko, Shinno, Kanako, Ohtake, Yosuke, Shimizu, Sawako, Asada, Akiko, Hisanaga, Shin-ichi, Iijima, Koichi M., Ando, Kanae

“…Abnormal accumulation of the microtubule-associated protein tau is thought to cause neuronal cell death in a group of age-associated neurodegenerative…”
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Reactive astrocyte scar and axon regeneration：suppressor or facilitator by Ohtake, Yosuke, Smith, George, Li, Shuxin

“…Several major factors are known to contribute to CNS axon regenerative failure after injury, including reduced intrinsic growth capacity of developed neurons…”
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The Modified High-Density Survival Assay is the Useful Tool to Predict the Effectiveness of Fractionated Radiation Exposure by Kuwahara, Yoshikazu, Mori, Miyuki, Oikawa, Toshiyuki, Shimura, Tsutomu, Ohtake, Yosuke, Mori, Shiro, Ohkubo, Yasuhito, Fukumoto, Manabu

“…The high-density survival (HDS) assay was originally elaborated to assess cancer cell responses to therapeutic agents under the influence of intercellular…”
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