MEROPENEM IN THE TREATMENT OF PATIENTS WITH SURGICAL INFECTIONS

We gave meropenem to six patients undergoing biliary drainage and studied its pharmacokinetics. We also treated 42 surgical infections in 41 patients with this drug and evaluated its clinical efficacy. In the pharmacokinetic study, 0.5 g was infused intravenously. The peak levels in plasma, 10.5 to...

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Bibliographic Details
Published in:	CHEMOTHERAPY Vol. 40; no. Supplement1; pp. 537 - 552
Main Authors:	Morimoto, Ken, Kinoshita, Hiroaki, Sakai, Katsuji, Nakatani, Shuichi, Ueda, Takami, Fujimoto, Mikio, Ohno, Koh-ichi, Kubo, Shoji, Ohta, Yasuatsu, Yamazaki, Osamu, Yamada, Tadashi, Hirata, Sanae, Muramatsu, Hideki, Ohmori, Kunio
Format:	Journal Article
Language:	Japanese
Published:	Japanese Society of Chemotherapy 25-04-1992
Subjects:	carbapenems Meropenem
Online Access:	Get full text
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Summary:	We gave meropenem to six patients undergoing biliary drainage and studied its pharmacokinetics. We also treated 42 surgical infections in 41 patients with this drug and evaluated its clinical efficacy. In the pharmacokinetic study, 0.5 g was infused intravenously. The peak levels in plasma, 10.5 to 36.0μg/ml, were at 0.5 hour. The peak levels in bile, 2.20 to 12.0μg/ml, were at 1 to 3 hours, and the level decreased from 0.1 to 1.6μg/ml at 5 to 6 hours. In the 42 surgical infections, the clinical efficacy of the drug was excellent in 20, good in 17, fair in four, and poor in one, with an efficacy rate of 88%. The bacteriological response could be evaluated in 25 of the 42 infections. The bacteria were eradicated in 19 infections, they decreased in three infections, they were replaced in one infection, and they persisted in two infections, an eradication rate of 76%. The bacteriological responses of 47 strains of organism isolated were evaluated. Forty strains were eradicated, two strains decreased, and five strains persisted, an eradication rate of 85%. The MIC levels were measured for 44 of the isolated bacterial strains. For six strains, MIC was 3.13 or more, so they probably could not be eradicated with this drug. Laboratory test results after administration of the drug were abnormal in seven patients. Changes were decreased hemoglobin and elevated transaminase, alkaline phosphatase, blood urea nitrogen, and creatinine.
ISSN:	0009-3165 1884-5894
DOI:	10.11250/chemotherapy1953.40.Supplement1_537