Search Results - "Ohsumi, Yoshinori"

Historical landmarks of autophagy research by Ohsumi, Yoshinori

“…The year of 2013 marked the 50th anniversary of C de Duve＇s coining of the term ＂autophagy＂ for the degradation process of cytoplasmic constituents in the…”
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Unveiling the Molecular Mechanisms of Plant Autophagy—From Autophagosomes to Vacuoles in Plants by Yoshimoto, Kohki, Ohsumi, Yoshinori

“…Abstract Autophagy is an evolutionarily conserved intracellular vacuolar process. Since Christian de Duve first coined the term ‘autophagy’ in 1963, it had not…”
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The Role of Atg Proteins in Autophagosome Formation by Mizushima, Noboru, Yoshimori, Tamotsu, Ohsumi, Yoshinori

“…Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of cytoplasm for delivery to the lysosome. Autophagosome…”
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Atg2 mediates direct lipid transfer between membranes for autophagosome formation by Osawa, Takuo, Kotani, Tetsuya, Kawaoka, Tatsuya, Hirata, Eri, Suzuki, Kuninori, Nakatogawa, Hitoshi, Ohsumi, Yoshinori, Noda, Nobuo N.

“…A key event in autophagy is autophagosome formation, whereby the newly synthesized isolation membrane (IM) expands to form a complete autophagosome using…”
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The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation by Kotani, Tetsuya, Kirisako, Hiromi, Koizumi, Michiko, Ohsumi, Yoshinori, Nakatogawa, Hitoshi

“…The biogenesis of double-membrane vesicles called autophagosomes, which sequester and transport intracellular material for degradation in lysosomes or…”
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Selectivity of mRNA degradation by autophagy in yeast by Makino, Shiho, Kawamata, Tomoko, Iwasaki, Shintaro, Ohsumi, Yoshinori

“…Synthesis and degradation of cellular constituents must be balanced to maintain cellular homeostasis, especially during adaptation to environmental stress. The…”
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Analysis of autophagy activated during changes in carbon source availability in yeast cells by Iwama, Ryo, Ohsumi, Yoshinori

“…Autophagy is a conserved intracellular degradation system in eukaryotes. Recent studies have revealed that autophagy can be induced not only by nitrogen…”
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Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling serine for one-carbon metabolism by May, Alexander I., Prescott, Mark, Ohsumi, Yoshinori

“…The mechanism and function of autophagy as a highly-conserved bulk degradation pathway are well studied, but the physiological role of autophagy remains poorly…”
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Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus by Mochida, Keisuke, Oikawa, Yu, Kimura, Yayoi, Kirisako, Hiromi, Hirano, Hisashi, Ohsumi, Yoshinori, Nakatogawa, Hitoshi

“…In yeast, the novel protein Atg40 is enriched in the cortical and cytoplasmic endoplasmic reticulum (ER), and loads these ER subdomains into autophagosomes to…”
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Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy by Okamoto, Koji, Kondo-Okamoto, Noriko, Ohsumi, Yoshinori

“…Mitochondria are essential organelles that produce most of the energy for a cell, but concomitantly accumulate oxidative damage. Degradation of damaged…”
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Phase separation organizes the site of autophagosome formation by Fujioka, Yuko, Alam, Jahangir Md, Noshiro, Daisuke, Mouri, Kazunari, Ando, Toshio, Okada, Yasushi, May, Alexander I., Knorr, Roland L., Suzuki, Kuninori, Ohsumi, Yoshinori, Noda, Nobuo N.

“…Many biomolecules undergo liquid–liquid phase separation to form liquid-like condensates that mediate diverse cellular functions 1 , 2 . Autophagy is able to…”
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Liquidity Is a Critical Determinant for Selective Autophagy of Protein Condensates by Yamasaki, Akinori, Alam, Jahangir Md, Noshiro, Daisuke, Hirata, Eri, Fujioka, Yuko, Suzuki, Kuninori, Ohsumi, Yoshinori, Noda, Nobuo N.

“…Clearance of biomolecular condensates by selective autophagy is thought to play a crucial role in cellular homeostasis. However, the mechanism underlying…”
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Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion by Matoba, Kazuaki, Kotani, Tetsuya, Tsutsumi, Akihisa, Tsuji, Takuma, Mori, Takaharu, Noshiro, Daisuke, Sugita, Yuji, Nomura, Norimichi, Iwata, So, Ohsumi, Yoshinori, Fujimoto, Toyoshi, Nakatogawa, Hitoshi, Kikkawa, Masahide, Noda, Nobuo N.

“…The molecular function of Atg9, the sole transmembrane protein in the autophagosome-forming machinery, remains unknown. Atg9 colocalizes with Atg2 at the…”
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Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae by Suzuki, Kuninori, Akioka, Manami, Kondo-Kakuta, Chika, Yamamoto, Hayashi, Ohsumi, Yoshinori

“…Autophagy is a bulk degradation system mediated by biogenesis of autophagosomes under starvation conditions. In Saccharomyces cerevisiae, a membrane sac called…”
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Autophagy induction under carbon starvation conditions is negatively regulated by carbon catabolite repression by Adachi, Atsuhiro, Koizumi, Michiko, Ohsumi, Yoshinori

“…Autophagy is a conserved process in which cytoplasmic components are sequestered for degradation in the vacuole/lysosomes in eukaryotic cells. Autophagy is…”
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The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function by Obara, Keisuke, Sekito, Takayuki, Niimi, Kaori, Ohsumi, Yoshinori

“…Atg18 is essential for both autophagy and the regulation of vacuolar morphology. The latter process is mediated by phosphatidylinositol 3,5-bisphosphate…”
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Atg8-family interacting motif crucial for selective autophagy by Noda, Nobuo N., Ohsumi, Yoshinori, Inagaki, Fuyuhiko

“…Autophagy is a bulk degradation system conserved among most eukaryotes. Recently, autophagy has been shown to mediate selective degradation of various targets…”
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Hierarchy of Atg proteins in pre‐autophagosomal structure organization by Suzuki, Kuninori, Kubota, Yuka, Sekito, Takayuki, Ohsumi, Yoshinori

“…Autophagy is a bulk degradation process that is conserved in eukaryotic cells and functions in the turnover of cytoplasmic materials and organelles. When…”
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Dynamics and diversity in autophagy mechanisms: lessons from yeast by Ohsumi, Yoshinori, Nakatogawa, Hitoshi, Suzuki, Kuninori, Kamada, Yoshiaki

“…Key Points Eukaryotic cells have evolved a degradative pathway called autophagy that can deliver a large amount of cytoplasmic proteins and even whole…”
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Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae by Suzuki, Kuninori, Ohsumi, Yoshinori

“…Autophagy is a degradation process accompanied by dynamic membrane organization. In the yeast, Saccharomyces cerevisiae, about 30 ATG (autophagy-related) genes…”
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