Search Results - "Ohsugi, Takeo"

Effects of expressing human T-cell leukemia virus type 1 (HTLV-I) oncoprotein Tax on DOK1, DOK2 and DOK3 gene expression in mice by OHSUGI, Takeo

“…Transgenic mice expressing the tax gene from human T-cell leukemia virus type 1 (HTLV-I) genome developed T-cell leukemia or histiocytic sarcoma after at least…”
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Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas by Yamagishi, Makoto, Hori, Makoto, Fujikawa, Dai, Ohsugi, Takeo, Honma, Daisuke, Adachi, Nobuaki, Katano, Harutaka, Hishima, Tsunekazu, Kobayashi, Seiichiro, Nakano, Kazumi, Nakashima, Makoto, Iwanaga, Masako, Utsunomiya, Atae, Tanaka, Yuetsu, Okada, Seiji, Tsukasaki, Kunihiro, Tobinai, Kensei, Araki, Kazushi, Watanabe, Toshiki, Uchimaru, Kaoru

“…Although global H3K27me3 reprogramming is a hallmark of cancer, no effective therapeutic strategy for H3K27me3-high malignancies harboring EZH2WT/WT has yet…”
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Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines by Kozako, Tomohiro, Mellini, Paolo, Ohsugi, Takeo, Aikawa, Akiyoshi, Uchida, Yu-Ichiro, Honda, Shin-Ichiro, Suzuki, Takayoshi

“…Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide -dependent deacylases, which participates in modulation of cell cycle…”
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CDK9 Inhibitor Induces Apoptosis, Autophagy, and Suppression of Tumor Growth in Adult T-Cell Leukemia/Lymphoma by Kato, Naho, Kozako, Tomohiro, Ohsugi, Takeo, Uchida, Yuichiro, Yoshimitsu, Makoto, Ishitsuka, Kenji, Aikawa, Akiyoshi, Honda, Shin-ichiro

“…Adult T-cell leukemia/lymphoma (ATL) is a hematopoietic malignancy with a poor prognosis that develops in approximately 5% of human T-cell leukemia virus type…”
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Anti-cancer activity of the cell membrane-permeable phytic acid prodrug by Masunaga, Takuya, Murao, Naoki, Tateishi, Hiroshi, Koga, Ryoko, Ohsugi, Takeo, Otsuka, Masami, Fujita, Mikako

“…[Display omitted] •Synthesis of a prodrug of IP6 (Pro-IP6) and identification of IP6 generated from Pro-IP6 in cells.•Selective anti-cancer effects including…”
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Elucidation of the Mechanism of Host NMD Suppression by HTLV-1 Rex: Dissection of Rex to Identify the NMD Inhibitory Domain by Nakano, Kazumi, Karasawa, Nobuaki, Hashizume, Masaaki, Tanaka, Yuetsu, Ohsugi, Takeo, Uchimaru, Kaoru, Watanabe, Toshiki

“…The human retrovirus human T-cell leukemia virus type I (HTLV-1) infects human T cells by vertical transmission from mother to child through breast milk or…”
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Anesthetic effect of a mixture of alfaxalone, medetomidine, and butorphanol for inducing surgical anesthesia in ICR, BALB/c, and C57BL/6 mouse strains by TSUKAMOTO, Yoriko, YAMADA, Norihide, MIYOSHI, Kenjiro, YAMASHITA, Kazuto, OHSUGI, Takeo

“…The anesthetic effects of alfaxalone combined with medetomidine and butorphanol were investigated for ICR, BALB/c, and C57BL/6 mice. Mice were administered a…”
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Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice by Ohsugi, Takeo, Kumasaka, Toshio

“…Human T-cell leukemia virus type I (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATL) as well as inflammatory diseases…”
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New SIRT2 inhibitors: Histidine-based bleomycin spin-off by Ali, Taha F.S., Ciftci, Halil I., Radwan, Mohamed O., Koga, Ryoko, Ohsugi, Takeo, Okiyama, Yoshio, Honma, Teruki, Nakata, Akiko, Ito, Akihiro, Yoshida, Minoru, Fujita, Mikako, Otsuka, Masami

“…[Display omitted] Bleomycin is considered to exert its antitumor activity via DNA cleavage mediated by activated oxygen generated from the iron complex in its…”
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Evaluation of a combination of alfaxalone with medetomidine and butorphanol for inducing surgical anesthesia in laboratory mice by Higuchi, Shota, Yamada, Riku, Hashimoto, Asami, Miyoshi, Kenjiro, Yamashita, Kazuto, Ohsugi, Takeo

“…The anesthetic effects of alfaxalone were investigated in mice. Mice were administered alfaxalone (100 mg/kg) alone or the combinations of 0.3 mg/kg of…”
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Increased production of viral proteins by a 3'-LTR-deleted infectious clone of human T-cell leukemia virus type 1 by Ohsugi, Takeo

“…We previously reported that a full-length provirus of HTLV-1 was directly constructed from the HTLV-1-transformed cell line MT-2 using overlapping polymerase…”
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antiretroviral potency of APOBEC1 deaminase from small animal species by Ikeda, Terumasa, Ohsugi, Takeo, Kimura, Tetsuya, Matsushita, Shuzo, Maeda, Yosuke, Harada, Shinji, Koito, Atsushi

“…Although the role of the APOBEC3-dependent retroelement restriction system as an intrinsic immune defense against human immunodeficiency virus type1 (HIV-1)…”
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Development and Molecular Analysis of Synthetic Lethality By Targeting EZH1 and EZH2 in Non-Hodgkin Lymphomas by Yamagishi, Makoto, Hori, Makoto, Fujikawa, Dai, Honma, Daisuke, Adachi, Nobuaki, Ohsugi, Takeo, Nakano, Kazumi, Nakashima, Makoto, Kobayashi, Seiichiro, Iwanaga, Masako, Utsunomiya, Atae, Okada, Seiji, Tsukasaki, Kunihiro, Tobinai, Kensei, Araki, Kazushi, Watanabe, Toshiki, Uchimaru, Kaoru

“…Epigenetic program is a molecular basis of cellular identity and functions. We have shown the transcriptome (Cancer Cell, 2012) and the underlying histone…”
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Altered CD4+/CD8+ T-cell ratio in splenocytes of human T-cell leukemia virus type I Tax transgenic mice with inflammatory arthropathy by Ohsugi, Takeo, Kumasaka, Toshio

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A novel mouse model of adult T‐cell leukemia cell invasion into the spinal cord by Ohsugi, Takeo, Tanaka, Shuhei, Iwasaki, Keigo, Nagano, Yusuke, Kozako, Tomohiro, Matsuda, Kazuya, Hirose, Takuya, Takehana, Kazushige

“…Adult T‐cell leukemia (ATL) is a mature T‐cell malignancy caused by human T‐cell leukemia virus type I infection, and 10%‐25% of patients show central nervous…”
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HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)-like disease and toxic epidermal necrolysis (TEN)-like disease in HTLV-1 Tax transgenic mice by Ohsugi, Takeo, Wakamiya, Makoto, Morikawa, Saki, Matsuura, Kumi, Kumasaka, Toshio, Yamaguchi, Kazunari

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Natural infection of murine norovirus in conventional and specific pathogen-free laboratory mice by Ohsugi, Takeo, Matsuura, Kumi, Kawabe, Satomi, Nakamura, Naoko, Kumar, Jerald M, Wakamiya, Makoto, Morikawa, Saki, Urano, Toru

“…Noroviruses cause most cases of acute viral gastroenteritis worldwide. The lack of a cell culture infection model for human norovirus necessitates the use of…”
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AICAR Induces AMPK-Independent Cell Death in Adult T-Cell Leukemia/Lymphoma and Has Anti-Tumor Activity by Kozako, Tomohiro, Aikawa, Akiyoshi, Ohsugi, Takeo, Honda, Shin-Ichiro

“…Introduction: Adult T-cell leukemia/lymphoma (ATL) is an aggressive T cell leukemia/lymphoma caused by human T-cell lymphotropic virus type I (HTLV-1) and has…”
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A transgenic mouse model of human T cell leukemia virus type 1-associated diseases by Ohsugi, Takeo

“…Human T cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T cell leukemia/lymphoma (ATLL) and several inflammatory diseases. Tax, the…”
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Anti-tumor activity of 5-aminoimidazole-4-carboxamide riboside with AMPK-independent cell death in human adult T-cell leukemia/lymphoma by Aikawa, Akiyoshi, Kozako, Tomohiro, Kato, Naho, Ohsugi, Takeo, Honda, Shin-Ichiro

“…Adult T-cell leukemia/lymphoma (ATL) is an aggressive T cell leukemia/lymphoma caused by human T-cell lymphotropic virus type I (HTLV-1). Acadesine or…”
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