Search Results - "Ohsaka, Akimichi"

Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms by Araki, Marito, Yang, Yinjie, Masubuchi, Nami, Hironaka, Yumi, Takei, Hiraku, Morishita, Soji, Mizukami, Yoshihisa, Kan, Shin, Shirane, Shuichi, Edahiro, Yoko, Sunami, Yoshitaka, Ohsaka, Akimichi, Komatsu, Norio

“…Recurrent somatic mutations of calreticulin (CALR) have been identified in patients harboring myeloproliferative neoplasms; however, their role in…”
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A new highly sensitive real-time quantitative-PCR method for detection of BCR-ABL1 to monitor minimal residual disease in chronic myeloid leukemia after discontinuation of imatinib by Kitamura, Hiroaki, Tabe, Yoko, Ai, Tomohiko, Tsuchiya, Koji, Yuri, Maiko, Misawa, Shigeki, Horii, Takashi, Kawaguchi, Atsushi, Ohsaka, Akimichi, Kimura, Shinya

“…Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 fusion protein, encoded by the Philadelphia chromosome, have drastically improved the outcomes for…”
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Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface by Masubuchi, Nami, Araki, Marito, Yang, Yinjie, Hayashi, Erina, Imai, Misa, Edahiro, Yoko, Hironaka, Yumi, Mizukami, Yoshihisa, Kihara, Yoshihiko, Takei, Hiraku, Nudejima, Mai, Koike, Masato, Ohsaka, Akimichi, Komatsu, Norio

“…Studies have shown that mutant calreticulin (CALR) constitutively activates the thrombopoietin (TPO) receptor MPL and thus plays a causal role in the…”
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Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation by Araki, Marito, Yang, Yinjie, Imai, Misa, Mizukami, Yoshihisa, Kihara, Yoshihiko, Sunami, Yoshitaka, Masubuchi, Nami, Edahiro, Yoko, Hironaka, Yumi, Osaga, Satoshi, Ohsaka, Akimichi, Komatsu, Norio

“…Studies have previously shown that mutant calreticulin (CALR), found in a subset of patients with myeloproliferative neoplasms (MPNs), interacts with and…”
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Automated diagnostic support system with deep learning algorithms for distinction of Philadelphia chromosome-negative myeloproliferative neoplasms using peripheral blood specimen by Kimura, Konobu, Ai, Tomohiko, Horiuchi, Yuki, Matsuzaki, Akihiko, Nishibe, Kumiko, Marutani, Setsuko, Saito, Kaori, Kaniyu, Kimiko, Takehara, Ikki, Uchihashi, Kinya, Ohsaka, Akimichi, Tabe, Yoko

“…Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-negative MPNs) such as polycythemia vera (PV), essential thrombocythemia (ET), and primary…”
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CREB3L1 overexpression as a potential diagnostic marker of Philadelphia chromosome–negative myeloproliferative neoplasms by Morishita, Soji, Yasuda, Hajime, Yamawaki, Saya, Kawaji, Hideya, Itoh, Masayoshi, Edahiro, Yoko, Imai, Misa, Kogo, Yasushi, Tsuneda, Satoshi, Ohsaka, Akimichi, Hayashizaki, Yoshihide, Ito, Masafumi, Araki, Marito, Komatsu, Norio

“…Discrimination of Philadelphia‐negative myeloproliferative neoplasms (Ph‐MPNs) from reactive hypercytosis and myelofibrosis requires a constellation of testing…”
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Clinical impacts of the mutational spectrum in Japanese patients with primary myelofibrosis by Morishita, Soji, Ochiai, Tomonori, Misawa, Kyohei, Osaga, Satoshi, Inano, Tadaaki, Fukuda, Yasutaka, Edahiro, Yoko, Ohsaka, Akimichi, Araki, Marito, Komatsu, Norio

“…Patients with primary myelofibrosis (PMF) have a poorer prognosis than those with other subtypes of myeloproliferative neoplasms (MPNs). To investigate the…”
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Mutational subtypes of JAK2 and CALR correlate with different clinical features in Japanese patients with myeloproliferative neoplasms by Misawa, Kyohei, Yasuda, Hajime, Araki, Marito, Ochiai, Tomonori, Morishita, Soji, Shirane, Shuichi, Edahiro, Yoko, Gotoh, Akihiko, Ohsaka, Akimichi, Komatsu, Norio

“…The majority of patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) harbor JAK2 , CALR , or MPL mutations. We compared clinical…”
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Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells by Sunami, Yoshitaka, Araki, Marito, Kan, Shin, Ito, Akihiro, Hironaka, Yumi, Imai, Misa, Morishita, Soji, Ohsaka, Akimichi, Komatsu, Norio

“…Differentiation therapy with all-trans-retinoic acid (ATRA) improves the treatment outcome of acute promyelocytic leukemia (APL); however, the molecular…”
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Evidence for prevention of renal dysfunction associated with primary myelofibrosis by cytoreductive therapy by Fukuda, Yasutaka, Araki, Marito, Yamamoto, Kouji, Morishita, Soji, Inano, Tadaaki, Misawa, Kyohei, Ochiai, Tomonori, Edahiro, Yoko, Imai, Misa, Yasuda, Hajime, Gotoh, Akihiko, Ohsaka, Akimichi, Komatsu, Norio

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The 24-h reporting of Gram stains from positive blood cultures contributes to physician's use of appropriate antimicrobials: Experience at a university hospital by Nishiyama, Miki, Osawa, Kazuhiko, Nakamura, Ayako, Kawakami, Takaaki, Chonan, Masayoshi, Misawa, Shigeki, Uehara, Yuki, Naito, Toshio, Ohsaka, Akimichi

“…Although recent technological advances for the diagnosis of bloodstream infection (BSI) provide rapid and accurate results, blood culture maintains a key role…”
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Evaluation of cell count and classification capabilities in body fluids using a fully automated Sysmex XN equipped with high-sensitive Analysis (hsA) mode and DI-60 hematology analyzer system by Takemura, Hiroyuki, Ai, Tomohiko, Kimura, Konobu, Nagasaka, Kaori, Takahashi, Toshihiro, Tsuchiya, Koji, Yang, Haeun, Konishi, Aya, Uchihashi, Kinya, Horii, Takashi, Tabe, Yoko, Ohsaka, Akimichi

“…The XN series automated hematology analyzer has been equipped with a body fluid (BF) mode to count and differentiate leukocytes in BF samples including…”
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The synergetic effect of Imipenem-clarithromycin combination in the Mycobacteroides abscessus complex by Takei, Satomi, Ihara, Hiroaki, Togo, Shinsaku, Nakamura, Ayako, Fujimoto, Yuichi, Watanabe, Junko, Kurokawa, Kana, Shibayama, Kohei, Sumiyoshi, Issei, Ochi, Yusuke, Iwai, Moe, Okabe, Takahiro, Chonan, Masayoshi, Misawa, Shigeki, Ohsaka, Akimichi, Takahashi, Kazuhisa

“…Nontuberculous mycobacteria (NTM) are ubiquitous organisms and the incidence of NTM infections has been increasing in recent years. Mycobacteroides abscessus…”
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Threshold for optimal administration of plerixafor in autologous peripheral blood stem cell collections through CD34+ cell monitoring based on the experience from two Japanese university hospitals by Okubo, Mitsuo, Furuta, Yoshiaki, Nakamura, Yuki, Osawa, Toshiya, Tada, Naoki, Sawada, Tomohiro, Yamatoya, Kenji, Sekiguchi, Yasunobu, Araki, Yoshihiko, Miyake, Kazunori, Noguchi, Masaaki, Komatsu, Norio, Ohsaka, Akimichi

“…Plerixafor was introduced to Japan in 2017 as a stem cell mobilization enhancement reagent, but the threshold for its use remains unclear. In this study, we…”
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Novel flowcytometry-based approach of malignant cell detection in body fluids using an automated hematology analyzer by Ai, Tomohiko, Tabe, Yoko, Takemura, Hiroyuki, Kimura, Konobu, Takahashi, Toshihiro, Yang, Haeun, Tsuchiya, Koji, Konishi, Aya, Uchihashi, Kinya, Horii, Takashi, Ohsaka, Akimichi

“…Morphological microscopic examinations of nucleated cells in body fluid (BF) samples are performed to screen malignancy. However, the morphological…”
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Impact of CD34+ pre-counting and plerixafor on autologous peripheral blood stem cell collection in Japanese university hospitals in eight years by Nakamura, Yuki, Okubo, Mitsuo, Furuta, Yoshiaki, Tokida, Miho, Ichikawa, Kayoko, Ohsaka, Akimichi

“…Over the past decade, there have been two major advancements in autologous peripheral blood stem cell (PBSC) collection, namely enumeration of CD 34+ cells for…”
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CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells by Jin, Linhua, Tabe, Yoko, Konoplev, Sergej, Xu, Yuanyuan, Leysath, Clinton E, Lu, Hongbo, Kimura, Shinya, Ohsaka, Akimichi, Rios, Mary-Beth, Calvert, Leslie, Kantarjian, Hagop, Andreeff, Michael, Konopleva, Marina

“…Chronic myelogenous leukemia (CML) is driven by constitutively activated Bcr-Abl tyrosine kinase, which causes the defective adhesion of CML cells to bone…”
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Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells by TABE, Yoko, LINHUA JIN, KONOPLEVA, Marina, TSUTSUMI-ISHII, Yuko, YUANYUAN XU, MCQUEEN, Teresa, PRIEBE, Waldemar, MILLS, Gordon B, OHSAKA, Akimichi, NAGAOKA, Isao, ANDREEFF, Michael

“…Integrin-linked kinase (ILK) directly interacts with beta integrins and phosphorylates Akt in a phosphatidylinositol 3-kinase (PI3K)-dependent manner. In this…”
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A survey of nurses to assess transfusion practice at the bedside using an electronic identification system: Experience at a university hospital by Nakamura, Yuki, Furuta, Yoshiaki, Tokida, Miho, Ichikawa, Kayoko, Shirahata, Mineko, Uzawa, Kumiko, Takizawa, Makiko, Okubo, Mitsuo, Ohsaka, Akimichi

“…Objectives The objective of this study was to assess the performance and recognition of transfusion practice at the bedside by nurses in our hospital, where a…”
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JAK2, CALR, and MPL mutation spectrum in Japanese patients with myeloproliferative neoplasms by Shirane, Shuichi, Araki, Marito, Morishita, Soji, Edahiro, Yoko, Takei, Hiraku, Yoo, Yongjin, Choi, Murim, Sunami, Yoshitaka, Hironaka, Yumi, Noguchi, Masaaki, Koike, Michiaki, Noda, Naohiro, Ohsaka, Akimichi, Komatsu, Norio

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