Search Results - "Ohno, Osamu"

Synthesis and Evaluation of DHMEQ Derivatives with Tertiary Hydroxyl Group Instead of Secondary Hydroxyl Group by Imanishi, Yoshimasa, Terasaki, Takuro, Sano, Takuya, Ohno, Osamu, Yasui, Eiko

“…Newly synthesized dehydroxymethyl epoxyquinomycin (DHMEQ) derivatives 6-9, which contain a tertiary hydroxyl group instead of the original secondary hydroxyl…”
Get full text

PFG acted as an inducer of premature senescence in TIG-1 normal diploid fibroblast and an inhibitor of mitosis in the HeLa cells by Huang, Ying, Ohno, Osamu, Miyamoto, Kenji

“…Our previous work has reported an anti-proliferative compound from moutan cortex, paeoniflorigenone which can induce cancer-selective apoptosis. However, its…”
Get full text

Total Synthesis of Caldorazole, a Potent Mitochondrial Respiratory Chain Inhibitor without Chiral Centers by Miyamoto, Yuta, Iwasaki, Arihiro, Fujimura, Haruka, Kudo, Chihiro, Kurisawa, Naoaki, Ohno, Osamu, Suenaga, Kiyotake

“…Caldorazole (1) is a novel polyketide that was isolated from a marine cyanobacterium in 2022. It is a unique natural product that exhibits potent inhibitory…”
Get full text

Antiapoptotic activity of methyl (3R,4E,6Z,15E)-3-hydroxyoctadecatrienoate in human cervical carcinoma HeLa cells by Ohno, Osamu, Sato, Keigo, Honma, Ryo, Chiba, Ruri, Matsuno, Kenji

“…Inhibitors of thapsigargin-induced cell death in human cervical carcinoma HeLa cells were screened among the metabolites of marine organisms. The MeOH extract…”
Get full text

Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex by Huang, Ying, Ohno, Osamu, Suenaga, Kiyotake, Miyamoto, Kenji

“…Ninety samples from the extracts of plants from traditional Chinese medicines were screened for antitumor activity. Paeoniflorigenone (PFG) was isolated as an…”
Get full text

Inhibitory effects of biseokeaniamide A against lipopolysaccharide-induced signal transduction by Ohno, Osamu, Terasaki, Takuro, Sano, Takuya, Hitomi, Yuki, Miyamoto, Junichiro, Matsuno, Kenji

“…[Display omitted] Lipopolysaccharides (LPS) are associated with various inflammatory diseases; therefore, the inhibition of LPS-induced nitric oxide (NO)…”
Get full text

Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes by Okamoto, Shinichiro, Iwasaki, Arihiro, Ohno, Osamu, Suenaga, Kiyotake

“…Kurahyne B (2), a new analogue of kurahyne (1), was isolated from the marine cyanobacterium Okeania sp. Its gross structure was elucidated based on…”
Get full text

Total synthesis and stereochemical determination of yoshinone A by Shinomiya, Seiichi, Iwasaki, Arihiro, Ohno, Osamu, Suenaga, Kiyotake

“…In 2014, the γ-pyrone-containing polyketide, yoshinone A, was isolated from the marine cyanobacterium Leptolyngbya sp. and its structure was determined…”
Get full text

Inhibition of Lipopolysaccharide-Induced Inflammatory Signaling by Soft Coral-Derived Prostaglandin A2 in RAW264.7 Cells by Ohno, Osamu, Mizuno, Eika, Miyamoto, Junichiro, Hoshina, Tomoyuki, Sano, Takuya, Matsuno, Kenji

“…Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria and causes inflammatory diseases. We searched MeOH extracts of…”
Get full text

Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta by Sumimoto, Shimpei, Kobayashi, Masayuki, Sato, Rio, Shinomiya, Seiichi, Iwasaki, Arihiro, Suda, Shoichiro, Teruya, Toshiaki, Inuzuka, Toshiyasu, Ohno, Osamu, Suenaga, Kiyotake

“…Minnamide A is a lipopeptide with a unique repeating structure consisting of hydroxy and proposed β-branched methyl groups. The absolute configuration of…”
Get full text

Biselyngbyolide B, a Novel ER Stress-inducer Isolated from the Marine Cyanobacterium Lyngbya sp by Ohno, Osamu, Watanabe, Ayane, Morita, Maho, Suenaga, Kiyotake

“…A novel cytotoxic macrolide biselyngbyolide B (1) was isolated from the marine cyanobacterium Lyngbya sp., collected on Ishigaki Island, Japan. The structure…”
Get full text

Structures and Biological Activities of Novel Biselyngbyaside Analogs Isolated from the Marine Cyanobacterium Lyngbya sp by Watanabe, Ayane, Ohno, Osamu, Morita, Maho, Inuzuka, Toshiyasu, Suenaga, Kiyotake

“…Novel biselyngbyaside analogs, biselyngbyolide C (1) and biselyngbyasides E (2) and F (3), were isolated from the marine cyanobacterium Lyngbya sp., collected…”
Get full text

Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis by Cui, Jin, Morita, Maho, Ohno, Osamu, Kimura, Tomoyuki, Teruya, Toshiaki, Watanabe, Takumi, Suenaga, Kiyotake, Shibasaki, Masakatsu

“…Four new macrolactones, leptolyngbyolides A–D, were isolated from the cyanobacterium Leptolyngbya sp. collected in Okinawa, Japan. The planar structures of…”
Get full text

Biselyngbyolide A, a Novel Cytotoxic Macrolide from the Marine Cyanobacterium Lyngbya sp by Morita, Maho, Ohno, Osamu, Suenaga, Kiyotake

“…A novel cytotoxic macrolide biselyngbyolide A (1) was isolated from the marine cyanobacterium Lyngbya sp., collected on Tokunoshima Island, Japan. This…”
Get full text

Phytotoxic property of Piper retrofractum fruit extracts and compounds against the germination and seedling growth of weeds by Suwitchayanon, Prapaipit, Ohno, Osamu, Suenaga, Kiyotake, Kato-Noguchi, Hisashi

“…The fruits of Piper retrofractum Vahl. contain a variety of compounds, but no phytotoxic compound with plant growth inhibitory activity has been reported…”
Get full text

Anti-obesity activities of the yoshinone A and the related marine γ-pyrone compounds by Koyama, Tomoyuki, Kawazoe, Yoshinori, Iwasaki, Arihiro, Ohno, Osamu, Suenaga, Kiyotake, Uemura, Daisuke

Get full text

An inhibitor of the adipogenic differentiation of 3T3-L1 cells, yoshinone A, and its analogs, isolated from the marine cyanobacterium Leptolyngbya sp by Inuzuka, Toshiyasu, Yamamoto, Keita, Iwasaki, Arihiro, Ohno, Osamu, Suenaga, Kiyotake, Kawazoe, Yoshinori, Uemura, Daisuke

“…[Display omitted] Three novel compounds, yoshinones A, B1, and B2, were isolated from the marine cyanobacterium Leptolyngbya sp., and their structures were…”
Get full text

Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides by Morita, Maho, Ohno, Osamu, Teruya, Toshiaki, Yamori, Takao, Inuzuka, Toshiyasu, Suenaga, Kiyotake

“…Bioassay-guided fractionation of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyasides B (3), C (4), and D (5), novel analogs of…”
Get full text

Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from Piper longum on Melanin Production in B16 Mouse Melanoma Cells by OHNO, Osamu, WATABE, Taeko, NAKAMURA, Kazuhiko, KAWAGOSHI, Masaru, UOTSU, Nobuo, CHIBA, Tomohiro, YAMADA, Masayoshi, YAMAGUCHI, Kohji, YAMADA, Kaoru, MIYAMOTO, Kenji, UEMURA, Daisuke

“…An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against α-melanocyte-stimulating hormone (α-MSH)-induced melanin…”
Get full text

Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 by Niwa, Hideaki, Watanabe, Chiduru, Sato, Shin, Harada, Toshiyuki, Watanabe, Hisami, Tabusa, Ryo, Fukasawa, Shunsuke, Shiobara, Ayane, Hashimoto, Tomoko, Ohno, Osamu, Nakamura, Kana, Tsuganezawa, Keiko, Tanaka, Akiko, Shirouzu, Mikako, Honma, Teruki, Matsuno, Kenji, Umehara, Takashi

“…trans-2-Phenylcycloproylamine (trans-PCPA) has been used as the scaffold to develop covalent-binding inhibitors against lysine-specific demethylase 1…”
Get full text