Search Results - "Ohno, Masuo"

PERK as a hub of multiple pathogenic pathways leading to memory deficits and neurodegeneration in Alzheimer’s disease by Ohno, Masuo

“…•PERK, an eIF2α kinase, is overly activated in Alzheimer’s disease (AD).•Fine-tuning of eIF2α phosphorylation is essential for learning and memory in…”
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Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model by Kimura, Ryoichi, Ohno, Masuo

“…Abstract Although animal models of Alzheimer's disease (AD) recapitulate β-amyloid-dependent hippocampal synaptic and cognitive dysfunctions, it is poorly…”
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Accelerated long‐term forgetting is a BACE1 inhibitor‐reversible incipient cognitive phenotype in Alzheimer’s disease model mice by Ohno, Masuo

“…Aim After the continued failure of β‐secretase (BACE1) inhibitor clinical trials in prodromal as well as mild‐to‐moderate Alzheimer's disease (AD), they are…”
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Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice by Devi, Latha, Ohno, Masuo

“…Abstract Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD) and may play an important role in the pathogenesis of disease. Emerging…”
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Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice by Devi, Latha, Ohno, Masuo

“…β-Site APP-cleaving enzyme 1 (BACE1) initiates amyloid-β (Aβ) generation and thus represents a prime therapeutic target in treating Alzheimer's disease (AD)…”
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Deletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease by Devi, Latha, Ohno, Masuo

“…Emerging evidence suggests that dysregulated translation through phosphorylation of eukaryotic initiation factor-2α (eIF2α) may contribute to Alzheimer's…”
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Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice by Kimura, Ryoichi, Devi, Latha, Ohno, Masuo

“…J. Neurochem. (2010) 10.1111/j.1471-4159.2010.06608.x β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) initiates amyloid-β (Aβ) generation that is…”
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Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease by Devi, Latha, Alldred, Melissa J, Ginsberg, Stephen D, Ohno, Masuo

“…Although evidence is accumulating that diabetes mellitus is an important risk factor for sporadic Alzheimer's disease (AD), the mechanisms by which defects in…”
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A combination Alzheimer's therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice by Devi, Latha, Ohno, Masuo

“…Accumulating evidence indicates that partial inhibition of β-site APP-cleaving enzyme 1 (BACE1), which initiates amyloid-β (Aβ) production, mitigates…”
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Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits by YANG, Dun-Sheng, STAVRIDES, Philip, PAWLIK, Monika, PETERHOFF, Corrinne M, YANG, Austin J, WILSON, Donald A, GEORGE-HYSLOP, Peter St, WESTAWAY, David, MATHEWS, Paul M, LEVY, Efrat, CUERVO, Ana M, NIXON, Ralph A, MOHAN, Panaiyur S, KAUSHIK, Susmita, KUMAR, Asok, OHNO, Masuo, SCHMIDT, Stephen D, WESSON, Daniel, BANDYOPADHYAY, Urmi, YING JIANG

“…Autophagy, a major degradative pathway for proteins and organelles, is essential for survival of mature neurons. Extensive autophagic-lysosomal pathology in…”
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BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice by Ohno, Masuo, Cole, Sarah L, Yasvoina, Marina, Zhao, Jie, Citron, Martin, Berry, Robert, Disterhoft, John F, Vassar, Robert

“…Abstract Evidence suggests that β-amyloid (Aβ) peptide triggers a pathogenic cascade leading to neuronal loss in Alzheimer’s disease (AD). However, the causal…”
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Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1 by Ohno, Masuo, Chang, Lei, Tseng, Wilbur, Oakley, Holly, Citron, Martin, Klein, William L., Vassar, Robert, Disterhoft, John F.

“…Transgenic mouse models of Alzheimer's disease (AD) exhibit amyloid‐β (Aβ) accumulation and related cognitive impairments. Although deficits in…”
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Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease by Devi, Latha, Alldred, Melissa J, Ginsberg, Stephen D, Ohno, Masuo

“…It is hypothesized that complex interactions between multiple environmental factors and genetic factors are implicated in sporadic Alzheimer's disease (AD);…”
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Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1 by Silva, Alcino J, Costa, Rui M, Federov, Nikolai B, Kogan, Jeff H, Murphy, Geoffrey G, Stern, Joel, Ohno, Masuo, Kucherlapati, Raju, Jacks, Tyler

“…Neurofibromatosis type I (NF1) is one of the most common single-gene disorders that causes learning deficits in humans. Mice carrying a heterozygous null…”
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Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis by Yang, Dun-Sheng, Stavrides, Philip, Mohan, Panaiyur S., Kaushik, Susmita, Kumar, Asok, Ohno, Masuo, Schmidt, Stephen D., Wesson, Daniel W., Bandyopadhyay, Urmi, Jiang, Ying, Pawlik, Monika, Peterhoff, Corrinne M., Yang, Austin J., Wilson, Donald A., St. George-Hyslop, Peter, Westaway, David, Mathews, Paul M., Levy, Efrat, Cuervo, Ana Maria, Nixon, Ralph A.

“…The extensive autophagic-lysosomal pathology in Alzheimer disease (AD) brain has revealed a major defect in the proteolytic clearance of autophagy substrates…”
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Alzheimer’s therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies by Ohno, Masuo

“…Highlights • BACE1 knockout mice provide a useful model to test therapeutic β-secretase inhibition. • BACE1−/− mice show adverse phenotypes in line with a…”
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Increased Neuronal Excitability, Synaptic Plasticity, and Learning in Aged Kvβ1.1 Knockout Mice by Murphy, Geoffrey G., Fedorov, Nikolai B., Giese, K.Peter, Ohno, Masuo, Friedman, Eugenia, Chen, Rachel, Silva, Alcino J.

“…Background: Advancing age is typically accompanied by deficits in learning and memory. These deficits occur independently of overt pathology and are often…”
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PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease by Devi, Latha, Ohno, Masuo

“…Abstract Emerging evidence suggests that aberrant phosphorylation of eukaryotic initiation factor-2α (eIF2α) may induce synaptic failure and neurodegeneration…”
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7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease by Devi, Latha, Ohno, Masuo

“…Increasing evidence suggests that reductions in brain-derived neurotrophic factor (BDNF) and its receptor tyrosine receptor kinase B (TrkB) may have a role in…”
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Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory by Chen, Adele P., Ohno, Masuo, Giese, K. Peter, Kühn, Ralf, Chen, Rachel L., Silva, Alcino J.

“…Raf kinases are downstream effectors of Ras and upstream activators of the MEK‐ERK cascade. Ras and MEK‐ERK signaling play roles in learning and memory (L&M)…”
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