Search Results - "Ohnmacht, Cyrus J."

Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists by OHNMACHT, Cyrus J, ALBERT, Jeffrey S, BERNSTEIN, Peter R, RUMSEY, William L, MASEK, Brian B, DEMBOFSKY, Bruce T, KOETHER, Gerard M, ANDISIK, Donald W, AHARONY, David

“…Previously we reported on the synthesis and properties of a series of highly potent piperidinyl 2-subsituted-3-cyano-1-naphthamide NK1 antagonists that…”
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Development and SAR of functionally selective allosteric modulators of GABAA receptors by Alhambra, Cristobal, Becker, Chris, Blake, Timothy, Chang, Amy (Hui-Fang), Damewood, James R., Jr, Daniels, Thalia, Dembofsky, Bruce T, Gurley, David A, Hall, James E, Herzog, Keith J, Horchler, Carey L, Ohnmacht, Cyrus J, Schmiesing, Richard Jon, Dudley, Adam, Ribadeneira, Maria D, Knappenberger, Katherine S, Maciag, Carla, Stein, Mark M, Chopra, Maninder, Liu, Xiaodong F, Christian, Edward P, Arriza, Jeffrey L, Chapdelaine, Marc J

“…Positive modulators at the benzodiazepine site of α2- and α3-containing GABAA receptors are believed to be anxiolytic. Through oocyte voltage clamp studies, we…”
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Behavioral Approach to Nondyskinetic Dopamine Antagonists:  Identification of Seroquel by Warawa, Edward J, Migler, Bernard M, Ohnmacht, Cyrus J, Needles, Ann L, Gatos, George C, McLaren, Frances M, Nelson, Cynthia L, Kirkland, Karen M

“…A great need exists for antipsychotic drugs which will not induce extrapyramidal symptoms (EPS) and tardive dyskinesias (TDs). These side effects are deemed to…”
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Discovery of novel, orally active dual NK1/NK2 antagonists by BERNSTEIN, Peter R, AHARONY, David, KOSMIDER, Benedict J, KIRKLAND, Karin, OHNMACHT, Cyrus J, POTTS, William, RUMSEY, William L, LIHONG SHEN, SHENVI, Ashok, SHERWOOD, Scott, STOLLMAN, David, RUSSELL, Keith, ALBERT, Jeffrey S, ANDISIK, Donald, BARTHLOW, Herbert G, BIALECKI, Russell, DAVENPORT, Timothy, DEDINAS, Robert F, DEMBOFSKY, Bruce T, KOETHER, Gerard

“…Exploration of the SAR around selective NK2 antagonists, SR48968 and ZD7944, led to the discovery that naphth-1-amide analogues provide potent dual NK1 and NK2…”
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Development and SAR of functionally selective allosteric modulators of GABA A receptors by Alhambra, Cristobal, Becker, Chris, Blake, Timothy, Chang, Amy (Hui-Fang), Damewood, James R., Daniels, Thalia, Dembofsky, Bruce T., Gurley, David A., Hall, James E., Herzog, Keith J., Horchler, Carey L., Ohnmacht, Cyrus J., Schmiesing, Richard Jon, Dudley, Adam, Ribadeneira, Maria D., Knappenberger, Katherine S., Maciag, Carla, Stein, Mark M., Chopra, Maninder, Liu, Xiaodong F., Christian, Edward P., Arriza, Jeffrey L., Chapdelaine, Marc J.

“…New structural classes of functionally selective benzodiazepine-site allosteric modulators of GABA A receptors are reported. Positive modulators at the…”
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N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides:  KATP Potassium Channel Openers. Modifications on the Western Region by Ohnmacht, Cyrus J, Russell, Keith, Empfield, James R, Frank, Cathy A, Gibson, Keith H, Mayhugh, Daniel R, McLaren, Frances M, Shapiro, Howard S, Brown, Frederick J, Trainor, Diane A, Ceccarelli, Christopher, Lin, Margaret M, Masek, Brian B, Forst, Janet M, Harris, Robert J, Hulsizer, James M, Lewis, Joseph J, Silverman, Stuart M, Smith, Reed W, Warwick, Paul J, Kau, Sen T, Chun, Alexa L, Grant, Thomas L, Howe, Burton B, Li, Jack H, Trivedi, Shephali, Halterman, Tracy J, Yochim, Christopher, Dyroff, Martin C, Neilson, Kathleen L

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N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides:  KATP Potassium Channel Openers. Modifications on the Western Region by Ohnmacht, Cyrus J, Russell, Keith, Empfield, James R, Frank, Cathy A, Gibson, Keith H, Mayhugh, Daniel R, McLaren, Frances M, Shapiro, Howard S, Brown, Frederick J, Trainor, Diane A, Ceccarelli, Christopher, Lin, Margaret M, Masek, Brian B, Forst, Janet M, Harris, Robert J, Hulsizer, James M, Lewis, Joseph J, Silverman, Stuart M, Smith, Reed W, Warwick, Paul J, Kau, Sen T, Chun, Alexa L, Grant, Thomas L, Howe, Burton B, Li, Jack H, Trivedi, Shephali, Halterman, Tracy J, Yochim, Christopher, Dyroff, Martin C, Kirkland, M, Neilson, Kathleen L

“…A subset of antiandrogen compounds, the N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides 1, were found to activate ATP sensitive potassium channels (KATP)…”
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Development and SAR of functionally selective allosteric modulators of GABA sub(A receptors) by Alhambra, Cristobal, Becker, Chris, Blake, Timothy, Chang, Amy, Damewood, James R, Daniels, Thalia, Dembofsky, Bruce T, Gurley, David A, Hall, James E, Herzog, Keith J, Horchler, Carey L, Ohnmacht, Cyrus J, Schmiesing, Richard Jon, Dudley, Adam, Ribadeneira, Maria D, Knappenberger, Katherine S, Maciag, Carla, Stein, Mark M, Chopra, Maninder, Liu, Xiaodong F, Christian, Edward P, Arriza, Jeffrey L, Chapdelaine, Marc J

“…Positive modulators at the benzodiazepine site of alpha 2- and alpha 3-containing GABA sub(A receptors are believed to be anxiolytic. Through oocyte voltage…”
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The Synthesis of Octahydro-7-phenylpyrazino[2,1-b][3]benzazepines by Ohnmacht Jr, Cyrus J., Mclaren, Frances M.

“…Octahydro‐7‐phenylpyrazino[2,1‐b][3]benzazepine (1a) was prepared from 1‐methyl‐3‐phenylmethylpiperazine 5a by reaction with styrene oxide followed by sulfuric…”
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Nuclear magnetic resonance spectra of some poly-nuclear thiapyrylium cations by Young, Thomas Edwin, Ohnmacht, Cyrus J

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A correlation of the lowest Hueckel molecular orbital transition energies with the L(sub b) band frequencies of thiapyrylium ions by Young, Thomas Edwin, Ohnmacht, Cyrus J

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Indolothiapyrylium compounds. IV. Indolo[3,2-c]- thiapyrylium perchlorate by Young, Thomas Edwin, Ohnmacht, Cyrus J

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Naphtho[2,1- b][1,5] and [1,2- f][1,4]oxazocines as selective NK 1 antagonists by Ohnmacht, Cyrus J., Albert, Jeffrey S., Bernstein, Peter R., Rumsey, William L., Masek, Brian B., Dembofsky, Bruce T., Koether, Gerard M., Andisik, Donald W., Aharony, David

“…A series of stepwise structural modifications of the NK 1-selective ZD4974 enabled further refinement of a previously reported NK 1 pharmacophore model…”
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Synthesis and carbon-13 NMR study of 2-benzyl, 2-methyl, 2-aryloctahydropyrrolo [3,4-c] pyrroles and the 1,2,3,5-tetrahydropyrrolo [3,4-c] pyrrole ring system by Ohnmacht Jr, Cyrus J., Draper, Clyde W., Dedinas, Robert F., Loftus, Philip, Wong, J. J.

“…2‐Benzyl, 2‐phenyl, 2‐ (3‐methoxyphenyl) and 2‐(3‐trifluoromethylphenyl) octahydropyrrolo[3,4‐c]pyrrole (9a, 9b, 9c, and 9d, respectively) were prepared in…”
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Antimalarials. 5. .alpha.-Dibutylaminomethyl- and .alpha.-(2-piperidyl)-3-quinolinemethanols by Lutz, Robert E, Ohnmacht, Cyrus J, Davis, Freddy

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Quinoline synthesis by o-amino ketone-propiolate addition by Heindel, Ned D, Kennewell, Peter D, Ohnmacht, Cyrus J

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Indolothiopyrylium compounds. III. Pseudoazulenic thiopyrano[4,3-b]indoles by Young, Thomas Edwin, Ohnmacht, Cyrus J, Hamel, Cokman R, Kamel, Coleman R

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Antimalarials. 10. Substituted 3-halo- and 3-methoxy-2-aryl-4-quinoline(dibutylaminomethyl)methanols by Munson, H. Randall, Johnson, Richard E, Sanders, J. Milton, Ohnmacht, Cyrus J, Lutz, Robert E

“…Four 2-aryl-4-quinoline(di-n-butylaminomethyl)methanols with Br, Cl, F, or OMe in position 3 were synthesized by modifications of standard reactions. The…”
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Antimalarials. 6. New .alpha.-alkylaminomethyl-4-quinolinemethanols by Lutz, Robert E, Patel, Atul R, Ohnmacht, Cyrus J, Clifford, D. P, Crosby, A. S

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A Novel Synthesis of N-dialkylaminoalkylbenzimidazoles by Heindel, Ned D, Orloff, John E, Ohnmacht, Cyrus J

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