Search Results - "Ohnishi, Yoshinori N"

Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine by Shuto, Takahide, Kuroiwa, Mahomi, Sotogaku, Naoki, Kawahara, Yukie, Oh, Yong-Seok, Jang, Jin-Hyeok, Shin, Chang-Hoon, Ohnishi, Yoshinori N., Hanada, Yuuki, Miyakawa, Tsuyoshi, Kim, Yong, Greengard, Paul, Nishi, Akinori

“…Depression is a leading cause of disability. Current pharmacological treatment of depression is insufficient, and development of improved treatments especially…”
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Antidepressant Actions of Histone Deacetylase Inhibitors by Covington, Herbert E., III, Maze, Ian, LaPlant, Quincey C, Vialou, Vincent F, Ohnishi, Yoshinori N, Berton, Olivier, Fass, Dan M, Renthal, William, Rush, Augustus J., III, Wu, Emma Y, Ghose, Subroto, Krishnan, Vaishnav, Russo, Scott J, Tamminga, Carol, Haggarty, Stephen J, Nestler, Eric J

“…Persistent symptoms of depression suggest the involvement of stable molecular adaptations in brain, which may be reflected at the level of chromatin…”
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Dysregulation of dopamine neurotransmission in the nucleus accumbens in immobilization-induced hypersensitivity by Kishikawa, Yuki, Kawahara, Yukie, Ohnishi, Yoshinori N., Sotogaku, Naoki, Koeda, Tomoko, Kawahara, Hiroshi, Nishi, Akinori

“…Cast immobilization causes sensory hypersensitivity, which is also a symptom of neuropathic pain and chronic pain. However, the mechanisms underlying…”
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Distinct Role of Dopamine in the PFC and NAc During Exposure to Cocaine-Associated Cues by Kawahara, Yukie, Ohnishi, Yoshinori N, Ohnishi, Yoko H, Kawahara, Hiroshi, Nishi, Akinori

“…Abstract Background Dopamine neurotransmission plays a critical role in reward in drug abuse and drug addiction. However, the role of dopamine in the…”
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Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance by Eagle, Andrew L., Manning, Claire E., Williams, Elizabeth S., Bastle, Ryan M., Gajewski, Paula A., Garrison, Amber, Wirtz, Alexis J., Akguen, Seda, Brandel-Ankrapp, Katie, Endege, Wilson, Boyce, Frederick M., Ohnishi, Yoshinori N., Mazei-Robison, Michelle, Maze, Ian, Neve, Rachel L., Robison, Alfred J.

“…Chronic stress is a key risk factor for mood disorders like depression, but the stress-induced changes in brain circuit function and gene expression underlying…”
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BDNF Is a Negative Modulator of Morphine Action by Koo, Ja Wook, Mazei-Robison, Michelle S., Chaudhury, Dipesh, Juarez, Barbara, LaPlant, Quincey, Ferguson, Deveroux, Feng, Jian, Sun, Haosheng, Scobie, Kimberly N., Damez-Werno, Diane, Crumiller, Marshall, Ohnishi, Yoshinori N., Ohnishi, Yoko H., Mouzon, Ezekiell, Dietz, David M., Lobo, Mary Kay, Neve, Rachael L., Russo, Scott J., Han, Ming-Hu, Nestler, Eric J.

“…Brain-derived neurotrophic factor (BDNF) is a key positive regulator of neural plasticity, promoting, for example, the actions of stimulant drugs of abuse such…”
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Subregion-Specific Regulation of Dopamine D1 Receptor Signaling in the Striatum: Implication for L-DOPA-Induced Dyskinesia by Sugiyama, Keita, Kuroiwa, Mahomi, Shuto, Takahide, Ohnishi, Yoshinori N, Kawahara, Yukie, Miyamoto, Yuta, Fukuda, Takaichi, Nishi, Akinori

“…The striatum is the main structure of the basal ganglia. The striatum receives inputs from various cortical areas, and its subregions play distinct roles in…”
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A silent synapse-based mechanism for cocaine-induced locomotor sensitization by Brown, Travis E, Lee, Brian R, Mu, Ping, Ferguson, Deveroux, Dietz, David, Ohnishi, Yoshinori N, Lin, Ying, Suska, Anna, Ishikawa, Masago, Huang, Yanhua H, Shen, Haowei, Kalivas, Peter W, Sorg, Barbara A, Zukin, R Suzanne, Nestler, Eric J, Dong, Yan, Schlüter, Oliver M

“…Locomotor sensitization is a common and robust behavioral alteration in rodents whereby following exposure to abused drugs such as cocaine, the animal becomes…”
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PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens by Ohnishi, Yoko H, Ohnishi, Yoshinori N, Nakamura, Takanori, Ohno, Mizuki, Kennedy, Pamela J, Ohkawa, Yasuyuki, Yasuyuki, Ohkawa, Nishi, Akinori, Neve, Rachael, Tsuzuki, Teruhisa, Nestler, Eric J

“…ΔFosB is a stable transcription factor which accumulates in the nucleus accumbens (NAc), a key part of the brain's reward circuitry, in response to chronic…”
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Correction: PSMC5, a 19S proteasomal ATPase, regulates cocaine action in the nucleus accumbens by Ohnishi, Yoko H, Ohnishi, Yoshinori N, Nakamura, Takanori, Ohno, Mizuki, Kennedy, Pamela J, Ohkawa, Yasuyuki, Nishi, Akinori, Neve, Rachael, Tsuzuki, Teruhisa, Nestler, Eric J

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Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments by Sin, Ryusuke, Sotogaku, Naoki, Ohnishi, Yoshinori N., Shuto, Takahide, Kuroiwa, Mahomi, Kawahara, Yukie, Sugiyama, Keita, Murakami, Yuki, Kanai, Masaaki, Funakoshi, Hiroshi, Chakraborti, Ayanabha, Bibb, James A, Nishi, Akinori

“…•680C91 attenuates LPS-induced pro-inflammatory cytokines in macrophages.•Attenuation of cytokine responses via STAT-mediated, TDO-independent…”
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Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition by Covington, Herbert E., Vialou, Vincent F., LaPlant, Quincey, Ohnishi, Yoshinori N., Nestler, Eric J.

“…► Repeated stress causes a persistent decrease in acH3K14 in hippocampus. ► Stress-induced deficits in acH3 in hippocampus are reversed by chronic fluoxetine…”
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Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia by Nomaru, Hiroko, Sakumi, Kunihiko, Katogi, Atsuhisa, Ohnishi, Yoshinori N., Kajitani, Kosuke, Tsuchimoto, Daisuke, Nestler, Eric J., Nakabeppu, Yusaku

“…The Fosb gene encodes subunits of the activator protein‐1 transcription factor complex. Two mature mRNAs, Fosb and ΔFosb, encoding full‐length FOSB and ΔFOSB…”
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ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses by LaPlant, Quincey C, Watts, Emily L, Dietz, David M, Vialou, Vincent, Ohnishi, Yoko H, Wallace, Deanna L, Steiner, Michel A, Tamminga, Carol A, Ohnishi, Yoshinori N, Mouzon, Ezekiell, Warren, Brandon L, Bolaños, Carlos A, Nestler, Eric J, Neve, Rachael L, Rush, Augustus J, Iñiguez, Sergio D, Ghose, Subroto, Krishnan, Vaishnav, Robison, Alfred J, Covington, Herbert E, Berton, Olivier

“…This study reports that the induction of the transcription factor ΔFosB is critical for mice to show resilience to the effects of chronic social defeat stress…”
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fosB-Null Mice Display Impaired Adult Hippocampal Neurogenesis and Spontaneous Epilepsy with Depressive Behavior by YUTSUDO, Noriko, KAMADA, Takashi, NAKABEPPU, Yusaku, KAJITANI, Kosuke, NOMARU, Hiroko, KATOGI, Atsuhisa, OHNISHI, Yoko H, OHNISHI, Yoshinori N, TAKASE, Kei-Ichiro, SAKUMI, Kunihiko, SHIGETO, Hiroshi

“…Patients with epilepsy are at high risk for major depression relative to the general population, and both disorders are associated with changes in adult…”
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FosB Is Essential for the Enhancement of Stress Tolerance and Antagonizes Locomotor Sensitization by ΔFosB by Ohnishi, Yoshinori N, Ohnishi, Yoko H, Hokama, Masaaki, Nomaru, Hiroko, Yamazaki, Katsuhisa, Tominaga, Yohei, Sakumi, Kunihiko, Nestler, Eric J, Nakabeppu, Yusaku

“…Background Molecular mechanisms underlying stress tolerance and vulnerability are incompletely understood. The fosB gene is an attractive candidate for…”
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Proteasome-dependent and -independent mechanisms for FosB destabilization: identification of FosB degron domains and implications for ΔFosB stability by Carle, Tiffany L., Ohnishi, Yoshinori N., Ohnishi, Yoko H., Alibhai, Imran N., Wilkinson, Matthew B., Kumar, Arvind, Nestler, Eric J.

“…The transcription factor ΔFosB (Delta FosB) accumulates in a region‐specific manner in the brain during chronic exposure to stress, drugs of abuse or other…”
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fosB-Null Mice Display Impaired Adult Hippocampal Neurogenesis and Spontaneous Epilepsy with Depressive Behavior by Yutsudo, Noriko, Kamada, Takashi, Kajitani, Kosuke, Nomaru, Hiroko, Katogi, Atsuhisa, Ohnishi, Yoko H, Ohnishi, Yoshinori N, Takase, Kei-ichiro, Sakumi, Kunihiko, Shigeto, Hiroshi, Nakabeppu, Yusaku

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FOSB proteins in the orbitofrontal and dorsolateral prefrontal cortices of human alcoholics by Watanabe, Hiroyuki, Henriksson, Richard, Ohnishi, Yoshinori N, Ohnishi, Yoko H, Harper, Clive, Sheedy, Donna, Garrick, Therese, Nyberg, Fred, Nestler, Eric J, Bakalkin, Georgy, Yakovleva, Tatjana

“…The transcription factor DeltaFosB is accumulated in the addiction circuitry, including the orbitofrontal and medial prefrontal cortices of rodents chronically…”
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Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia: Fosb Regulates Expression of C5a Receptors by Nomaru, Hiroko, Sakumi, Kunihiko, Katogi, Atsuhisa, Ohnishi, Yoshinori N., Kajitani, Kosuke, Tsuchimoto, Daisuke, Nestler, Eric J., Nakabeppu, Yusaku

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