Search Results - "Ohnishi, Hirohide"

Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease by Miura, Kouichi, Ohnishi, Hirohide

“…Emerging data have shown a close association between compositional changes in gut microbiota and the development of nonalcoholic fatty liver disease(NAFLD).The…”
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Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2 by Miura, Kouichi, Yang, Ling, van Rooijen, Nico, Ohnishi, Hirohide, Seki, Ekihiro

“…Inflammatory cell infiltration in the liver is a hallmark of nonalcoholic steatohepatitis (NASH). The chemokine-chemokine receptor interaction induces…”
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Toll‐like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice by Miura, Kouichi, Yang, Ling, van Rooijen, Nico, Brenner, David A., Ohnishi, Hirohide, Seki, Ekihiro

“…Innate immune signaling associated with Toll‐like receptors (TLRs) is a key pathway involved in the progression of nonalcoholic steatohepatitis (NASH). Here we…”
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Ezetimibe suppresses development of liver tumors by inhibiting angiogenesis in mice fed a high‐fat diet by Miura, Kouichi, Ohnishi, Hirohide, Morimoto, Naoki, Minami, Shinichiro, Ishioka, Mitsuaki, Watanabe, Shunji, Tsukui, Mamiko, Takaoka, Yoshinari, Nomoto, Hiroaki, Isoda, Norio, Yamamoto, Hironori

“…Nonalcoholic steatohepatitis (NASH) is a common cause of liver cirrhosis and hepatocellular carcinoma (HCC). However, effective therapeutic strategies for…”
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Altered Gut Microbiota Composition and Immune Response in Experimental Steatohepatitis Mouse Models by Ishioka, Mitsuaki, Miura, Kouichi, Minami, Shinichiro, Shimura, Yoichiro, Ohnishi, Hirohide

“…Background Although several types of diet have been used in experimental steatohepatitis models, comparison of gut microbiota and immunological alterations in…”
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Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice by Miura, Kouichi, Ishioka, Mitsuaki, Minami, Shinichiro, Horie, Yasuo, Ohshima, Shigetoshi, Goto, Takashi, Ohnishi, Hirohide

“…The role of Toll-like receptor (TLR) signaling has attracted much attention in the development of hepatic inflammation and hepatocellular carcinoma (HCC). We…”
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Randomized controlled trial comparing the costs of gastric cancer screening systems between serological risk-based upper gastrointestinal endoscopy and the existing barium photofluorography: gastric cancer screening labeled by serum examination in place of aged gastric cancer organized screening systems (GALAPAGOS study) by Gotoda, Takuji, Ishikawa, Hideki, Kusano, Chika, Suzuki, Sho, Ohnishi, Hirohide, Sugano, Kentaro, Matsuyama, Yutaka

“…Background Although the risk of gastric cancer can be stratified according to Helicobacter pylori ( H. pylori ) IgG antibody titer and pepsinogen levels (ABC…”
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Rab7 localized on zymogen granules is involved in maturation but not in autophagy or regulated exocytosis in pancreatic acinar cells by Takahashi, Kenichi, Mashima, Hirosato, Sekine, Masanari, Uehara, Takeshi, Asano, Takeharu, Sun-Wada, Ge-Hong, Wada, Yoh, Ohnishi, Hirohide

“…Rab7 is known to function in the autophagy and endocytosis pathways in eukaryocytes and is related to various diseases. We recently reported that Rab7 plays a…”
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A Comparative Study of Endoscopic Ultrasonography and Histopathology Images for the Diagnosis of Early Chronic Pancreatitis by Sekine, Masanari, Tanaka, Akira, Akimoto, Maho, Miura, Takaya, Fujiwara, Junichi, Noda, Hiroshi, Rikiyama, Toshiki, Ohnishi, Hirohide, Mashima, Hirosato

“…The concept of early chronic pancreatitis (ECP) and its diagnostic criteria were first proposed by Japan, using endoscopic ultrasonography (EUS) findings for…”
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The role of calcium-binding protein S100g (CalbindinD-9K) and annexin A10 in acute pancreatitis by Mashima, Hirosato, Takahashi, Kenichi, Sekine, Masanari, Matsumoto, Satohiro, Asano, Takeharu, Uehara, Takeshi, Fujiwara, Junichi, Otake, Haruka, Ishii, Takehiro, Yoshikawa, Shuhei, Miura, Takaya, Koito, Yudai, Kashima, Hitomi, Matsumoto, Keita, Ohnishi, Hirohide

“…We reported that the pancreas of the interferon-regulatory factor (IRF) 2 knock-out (KO) mouse represents an early phase of acute pancreatitis, including…”
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Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models by Takahashi, Kenichi, Mashima, Hirosato, Miura, Kouichi, Maeda, Daichi, Goto, Akiteru, Goto, Takashi, Sun-Wada, Ge-Hong, Wada, Yoh, Ohnishi, Hirohide

“…Although aberrations of intracellular vesicle transport systems towards lysosomes including autophagy and endocytosis are involved in the onset and progression…”
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Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease by Miura, Kouichi, Seki, Ekihiro, Ohnishi, Hirohide, Brenner, David A.

“…Activation of innate immunity is associated with the development of liver disease, including non-alcoholic fatty liver disease (NAFLD). In the innate immune…”
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Outcomes of patients receiving additional esophagectomy after endoscopic resection for clinically mucosal, but pathologically submucosal, squamous cell carcinoma of the esophagus by Motoyama, Satoru, Jin, Mario, Matsuhashi, Tamotsu, Nanjo, Hiroshi, Ishiyama, Koichi, Sato, Yusuke, Yoshino, Kei, Sasaki, Tomohiko, Wakita, Akiyuki, Saito, Hajime, Minamiya, Yoshihiro, Ohnishi, Hirohide, Ogawa, Jun-ichi

“…Purpose This study investigated the actual rate or extent of lymph node metastasis or the survival outcomes among patients that underwent esophagectomy with…”
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Clinical course of gastrointestinal stromal tumor diagnosed by endoscopic ultrasound-guided fine-needle aspiration by Sekine, Masanari, Imaoka, Hiroshi, Mizuno, Nobumasa, Hara, Kazuo, Hijioka, Susumu, Niwa, Yasumasa, Tajika, Masahiro, Tanaka, Tsutomu, Ishihara, Makoto, Ito, Seiji, Misawa, Kazunari, Ito, Yuichi, Shimizu, Yasuhiro, Yatabe, Yasushi, Ohnishi, Hirohide, Yamao, Kenji

“…Background and Aim Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumor of the gastrointestinal tract. However, little is known about…”
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Randomized controlled trial comparing gastric cancer screening by gastrointestinal X-ray with serology for Helicobacter pylori and pepsinogens followed by gastrointestinal endoscopy by Gotoda, Takuji, Ishikawa, Hideki, Ohnishi, Hirohide, Sugano, Kentaro, Kusano, Chika, Yokoi, Chizu, Matsuyama, Yutaka, Moriyasu, Fuminori

“…Background Based on the results of several case–control and cohort studies gastrointestinal X-ray (GI X-ray) has been recommended for use in the nationwide…”
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Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine by Takasuga, Shunsuke, Horie, Yasuo, Sasaki, Junko, Sun-Wada, Ge-Hong, Kawamura, Nobuyuki, Iizuka, Ryota, Mizuno, Katsunori, Eguchi, Satoshi, Kofuji, Satoshi, Kimura, Hirotaka, Yamazaki, Masakazu, Horie, Chihoko, Odanaga, Eri, Sato, Yoshiko, Chida, Shinsuke, Kontani, Kenji, Harada, Akihiro, Katada, Toshiaki, Suzuki, Akira, Wada, Yoh, Ohnishi, Hirohide, Sasaki, Takehiko

“…The metabolism of membrane phosphoinositides is critical for a variety of cellular processes. Phosphatidylinositol-3,5-bisphosphate [PtdIns(3,5)P ₂] controls…”
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The roles of interferon regulatory factors 1 and 2 in the progression of human pancreatic cancer by Sakai, Toshitaka, Mashima, Hirosato, Yamada, Yumi, Goto, Takashi, Sato, Wataru, Dohmen, Takahiro, Kamada, Kentaro, Yoshioka, Masato, Uchinami, Hiroshi, Yamamoto, Yuzo, Ohnishi, Hirohide

“…Pancreatic cancer is one of the most malignant diseases worldwide. Interferon regulatory factor (IRF) 1 and IRF2 function as a tumor suppressor and…”
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Advanced feasibility of endoscopic submucosal dissection for the treatment of gastric tube cancer after esophagectomy by Tawaraya, Shin, MD, Jin, Mario, MD, PhD, Matsuhashi, Tamotsu, MD, PhD, Suzuki, Yusato, MD, Sawaguchi, Masayuki, MD, Watanabe, Noboru, MD, Onochi, Kengo, MD, Koizumi, Shigeto, MD, PhD, Hatakeyama, Natsumi, MD, PhD, Ohba, Reina, MD, PhD, Mashima, Hirosato, MD, PhD, Ohnishi, Hirohide, MD, PhD

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Functional Roles of TGF-β1 in Intestinal Epithelial Cells Through Smad-Dependent and Non-Smad Pathways by Yamada, Yumi, Mashima, Hirosato, Sakai, Toshitaka, Matsuhashi, Tamotsu, Jin, Mario, Ohnishi, Hirohide

“…Background and Aims Transforming growth factor-β 1 (TGF-β 1 ) is one of the growth factors expressed in the gut, and has been shown to play an important role…”
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Salvage endoscopic submucosal dissection for the esophagus-localized recurrence of esophageal squamous cell cancer after definitive chemoradiotherapy by Koizumi, Shigeto, MD, PhD, Jin, Mario, MD, PhD, Matsuhashi, Tamotsu, MD, PhD, Tawaraya, Shin, MD, Watanabe, Noboru, MD, Sawaguchi, Masayuki, MD, Kanazawa, Noriyoshi, MD, Yamada, Yumi, MD, Onochi, Kengo, MD, Kimura, Yuko, MD, Ohba, Reina, MD, PhD, Kataoka, Jinko, MD, PhD, Hatakeyma, Natsumi, MD, PhD, Mashima, Hirosato, MD, PhD, Ohnishi, Hirohide, MD, PhD

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