Search Results - "Ohnesorge, Nils"

Current Methods to Investigate Nociception and Pain in Zebrafish by Ohnesorge, Nils, Heinl, Céline, Lewejohann, Lars

“…Pain is an unpleasant, negative emotion and its debilitating effects are complex to manage. Mammalian models have long dominated research on nociception and…”
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Assessment of the effect of tricaine (MS-222)-induced anesthesia on brain-wide neuronal activity of zebrafish ( Danio rerio ) larvae by Ohnesorge, Nils, Wilzopolski, Jenny, Steinfath, Matthias, Lewejohann, Lars, Banneke, Stefanie, Heinl, Céline

“…Fast and effective anesthesia is the key for refining many invasive procedures in fish and gaining reliable data. For fish as for all vertebrates, it is also…”
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Erk5 Activation Elicits a Vasoprotective Endothelial Phenotype via Induction of Krüppel-like Factor 4 (KLF4) by Ohnesorge, Nils, Viemann, Dorothee, Schmidt, Nicole, Czymai, Tobias, Spiering, Désirée, Schmolke, Mirco, Ludwig, Stephan, Roth, Johannes, Goebeler, Matthias, Schmidt, Marc

“…The MEK5/Erk5 MAPK cascade has recently been implicated in the regulation of endothelial integrity and represents a candidate pathway mediating the beneficial…”
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Automatic classification of experimental models in biomedical literature to support searching for alternative methods to animal experiments by Neves, Mariana, Klippert, Antonina, Knöspel, Fanny, Rudeck, Juliane, Stolz, Ailine, Ban, Zsofia, Becker, Markus, Diederich, Kai, Grune, Barbara, Kahnau, Pia, Ohnesorge, Nils, Pucher, Johannes, Schönfelder, Gilbert, Bert, Bettina, Butzke, Daniel

“…Current animal protection laws require replacement of animal experiments with alternative methods, whenever such methods are suitable to reach the intended…”
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Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae by Ohnesorge, Nils, Sasore, Temitope, Hillary, Daniel, Alvarez, Yolanda, Carey, Michelle, Kennedy, Breandán N

“…Unbiased screening of large randomized chemical libraries is a powerful tool to find new drugs and targets. However, forward chemical screens in zebrafish can…”
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MEK5/ERK5 Signaling Modulates Endothelial Cell Migration and Focal Contact Turnover by Spiering, Désirée, Schmolke, Mirco, Ohnesorge, Nils, Schmidt, Marc, Goebeler, Matthias, Wegener, Joachim, Wixler, Viktor, Ludwig, Stephan

“…The formation of new blood vessels from pre-existing ones requires highly coordinated restructuring of endothelial cells (EC) and the surrounding extracellular…”
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Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling by Lange, Martin, Ohnesorge, Nils, Hoffmann, Dennis, Rocha, Susana F., Benedito, Rui, Siekmann, Arndt F.

“…The formation of appropriately patterned blood vessel networks requires endothelial cell migration and proliferation. Signaling through the Vascular…”
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Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis by Wade, Sarah M., Ohnesorge, Nils, McLoughlin, Hayley, Biniecka, Monika, Carter, Steven P., Trenkman, Michelle, Cunningham, Clare C., McGarry, Trudy, Canavan, Mary, Kennedy, Breandán N., Veale, Douglas J., Fearon, Ursula

“…Although neoangiogenesis is a hallmark of chronic inflammatory diseases such as inflammatory arthritis and many cancers, therapeutic agents targeting the…”
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Vascularization and blood vessel patterning of the liver in zebrafish by Ohnesorge, Nils, Siekmann, Arndt F

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Dysregulated miR-125a promotes angiogenesis through enhanced glycolysisResearch in context by Sarah M. Wade, Nils Ohnesorge, Hayley McLoughlin, Monika Biniecka, Steven P. Carter, Michelle Trenkman, Clare C. Cunningham, Trudy McGarry, Mary Canavan, Breandán N. Kennedy, Douglas J. Veale, Ursula Fearon

“…Background: Although neoangiogenesis is a hallmark of chronic inflammatory diseases such as inflammatory arthritis and many cancers, therapeutic agents…”
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Wnt2 acts as an angiogenic growth factor for non-sinusoidal endothelial cells and inhibits expression of stanniocalcin-1 by Klein, Diana, Demory, Alexandra, Peyre, Francis, Kroll, Jens, Géraud, Cyrill, Ohnesorge, Nils, Schledzewski, Kai, Arnold, Bernd, Goerdt, Sergij

“…Recently, we have shown that Wnt2 is an autocrine growth and differentiation factor for hepatic sinusoidal endothelial cells. As Wnt signaling has become…”
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