Search Results - "Ohmura, Mari"

Galectin-9 deficiency exacerbates lipopolysaccharide-induced hypothermia and kidney injury by Onishi, Keisuke, Fu, Hai Ying, Sofue, Tadashi, Tobiume, Atsushi, Moritoki, Masahiro, Saiga, Hiroyuki, Ohmura-Hoshino, Mari, Hoshino, Katsuaki, Minamino, Tetsuo

“…Background Galectin-9 (Gal-9) is a multifunctional lectin that moderates inflammation and organ damage. In this study, we tested whether Gal-9 has a protective…”
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Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells by Baravalle, Günther, Park, Hyesuk, McSweeney, Megan, Ohmura-Hoshino, Mari, Matsuki, Yohei, Ishido, Satoshi, Shin, Jeoung-Sook

“…Dendritic cells (DCs) require costimulatory molecules such as CD86 to efficiently activate T cells for the induction of adaptive immunity. DCs maintain minimal…”
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A one-step multiplex PCR-based assay for simultaneous detection and classification of virulence factors to identify five diarrheagenic E. coli pathotypes by Ohmura-Hoshino, Mari, Miyaki, Yuki, Yashima, Shigeko

“…Human diarrhea-causing strains of Escherichia coli are referred to as diarrheagenic E. coli (DEC). DEC can be divided into five main categories based on…”
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CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation by Tze, Lina E, Horikawa, Keisuke, Domaschenz, Heather, Howard, Debbie R, Roots, Carla M, Rigby, Robert J, Way, David A, Ohmura-Hoshino, Mari, Ishido, Satoshi, Andoniou, Christopher E, Degli-Esposti, Mariapia A, Goodnow, Christopher C

“…Effective vaccine adjuvants must induce expression of major histocompatibility (MHC) class II proteins and the costimulatory molecule CD86 on dendritic cells…”
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Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells by Mount, Adele M, Villadangos, Jose A, Heath, William R, Stoorvogel, Willem, Proietto, Anna, Matsuki, Yohei, Wilson, Nicholas S, Ishido, Satoshi, Schnorrer, Petra, Belz, Gabrielle T, Ohmura-Hoshino, Mari, Shortman, Ken, O'Keeffe, Meredith, Young, Louise J, ten Broeke, Toine

“…The antigen-presenting abilities of plasmacytoid dendritic cells (DCs) are not well characterized. Villadangos and colleagues show that unlike conventional…”
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Inhibition of MHC Class II Expression and Immune Responses by c-MIR by Ohmura-Hoshino, Mari, Matsuki, Yohei, Aoki, Masami, Goto, Eiji, Mito, Mari, Uematsu, Mika, Kakiuchi, Terutaka, Hotta, Hak, Ishido, Satoshi

“…We previously reported a novel E3 ubiquitin ligase (E3), designated as c-MIR, which targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface…”
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Contribution of Lysine 11-linked Ubiquitination to MIR2-mediated Major Histocompatibility Complex Class I Internalization by Goto, Eiji, Yamanaka, Yuko, Ishikawa, Akiyo, Aoki-Kawasumi, Masami, Mito-Yoshida, Mari, Ohmura-Hoshino, Mari, Matsuki, Yohei, Kajikawa, Mizuho, Hirano, Hisashi, Ishido, Satoshi

“…The polyubiquitin chain is generated by the sequential addition of ubiquitin moieties to target molecules, a reaction between specific lysine residues that is…”
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Cutting Edge: Requirement of MARCH-I-Mediated MHC II Ubiquitination for the Maintenance of Conventional Dendritic Cells by Ohmura-Hoshino, Mari, Matsuki, Yohei, Mito-Yoshida, Mari, Goto, Eiji, Aoki-Kawasumi, Masami, Nakayama, Manabu, Ohara, Osamu, Ishido, Satoshi

“…MARCH-I (membrane-associated RING-CH I) has been suggested as a physiological E3 ubiquitin ligase for both MHC class II (MHC II) and B7-2. In this study, we…”
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Novel Family of Membrane-Bound E3 Ubiquitin Ligases by Ohmura-Hoshino, Mari, Goto, Eiji, Matsuki, Yohei, Aoki, Masami, Mito, Mari, Uematsu, Mika, Hotta, Hak, Ishido, Satoshi

“…A novel E3 ubiquitin ligase family that consists of viral E3 ubiquitin ligases (E3s) and their mammalian homologues was recently discovered. These novel E3s…”
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Nontoxic Shiga Toxin Derivatives from Escherichia coli Possess Adjuvant Activity for the Augmentation of Antigen-Specific Immune Responses via Dendritic Cell Activation by Ohmura, Mari, Yamamoto, Masafumi, Tomiyama-Miyaji, Chikako, Yuki, Yoshikazu, Takeda, Yoshifumi, Kiyono, Hiroshi

“…Shiga toxin (Stx) derivatives, such as the Stx1 B subunit (StxB1), which mediates toxin binding to the membrane, and mutant Stx1 (mStx1), which is a nontoxic…”
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PLAAT1 deficiency alleviates high‐fat diet‐induced hepatic lipid accumulation in mice by Rahman, S. M. Khaledur, Sasaki, Sumire, Uyama, Toru, Hussain, Zahir, Sikder, Mohammad Mamun, Saiga, Hiroyuki, Ohmura‐Hoshino, Mari, Ohta, Ken‐ichi, Miki, Yoshimi, Hoshino, Katsuaki, Ueno, Masaki, Murakami, Makoto, Ueda, Natsuo

“…The phospholipase A and acyltransferase (PLAAT) family is composed of three isoforms in mice (PLAAT1, 3, and 5), all of which function as…”
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MARCH-I: a new regulator of dendritic cell function by Ishido, Satoshi, Matsuki, Yohei, Goto, Eiji, Kajikawa, Mizuho, Ohmura-Hoshino, Mari

“…We and other groups have demonstrated that the expression level of MHC class II (MHC II) is regulated through ubiquitination of the MHC II beta chain. We also…”
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A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics by Yonashiro, Ryo, Ishido, Satoshi, Kyo, Shinkou, Fukuda, Toshifumi, Goto, Eiji, Matsuki, Yohei, Ohmura-Hoshino, Mari, Sada, Kiyonao, Hotta, Hak, Yamamura, Hirohei, Inatome, Ryoko, Yanagi, Shigeru

“…In this study, we have identified a novel mitochondrial ubiquitin ligase, designated MITOL, which is localized in the mitochondrial outer membrane. MITOL…”
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A Nontoxic Adjuvant for Mucosal Immunity to Pneumococcal Surface Protein A by Yamamoto, Masafumi, Briles, David E, Yamamoto, Shingo, Ohmura, Mari, Kiyono, Hiroshi, McGhee, Jerry R

“…In this study, we demonstrated that pneumococcal surface protein A (PspA) nasally administered with a nontoxic A subunit mutant of cholera toxin (mCT) S61F…”
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Novel regulation of MHC class II function in B cells by Matsuki, Yohei, Ohmura-Hoshino, Mari, Goto, Eiji, Aoki, Masami, Mito-Yoshida, Mari, Uematsu, Mika, Hasegawa, Takanori, Koseki, Haruhiko, Ohara, Osamu, Nakayama, Manabu, Toyooka, Kiminori, Matsuoka, Ken, Hotta, Hak, Yamamoto, Akitsugu, Ishido, Satoshi

“…The presence of post‐translational regulation of MHC class II (MHC II) under physiological conditions has been demonstrated recently in dendritic cells (DCs)…”
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Protective Immunity to Streptococcus mutans Induced by Nasal Vaccination with Surface Protein Antigen and Mutant Cholera Toxin Adjuvant by Masayuki Saito, Shigeo Otake, Mari Ohmura, Masatomo Hirasawa, Kazuko Takada, Junichi Mega, Ichiro Takahashi, Hiroshi Kiyono, McGhee, Jerry R., Yoshifumi Takeda, Masafumi Yamamotol

“…In this study, mice were immunized nasally with surface protein antigen of Streptococcus mutans serotype c (PAc) and a nontoxic A subunit mutant of cholera…”
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Non-toxic Stx derivatives from Escherichia coli possess adjuvant activity for mucosal immunity by Ohmura-Hoshino, Mari, Yamamoto, Masafumi, Yuki, Yoshikazu, Takeda, Yoshifumi, Kiyono, Hiroshi

“…Both B subunit of Shiga toxin 1 (Stx1-B), which mediates the binding of toxin to the membrane, and mutant Stx1 (mStx1), which is a non-toxic double-mutated…”
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Highly purified mutant E112K of cholera toxin elicits protective lung mucosal immunity to diphtheria toxin by Ohmura, Mari, Yamamoto, Masafumi, Kiyono, Hiroshi, Fujihashi, Kohtaro, Takeda, Yoshifumi, McGhee, Jerry R

“…We demonstrated that the mutant of cholera toxin (mCT) E112K which was LPS-free supported the induction of protective immunity in mucosal (e.g. lung lavage)…”
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Genetic and Immunological Analysis of a Novel Variant of Shiga Toxin 1 from Bovine Escherichia coli Strains and Development of Bead-ELISA to Detect the Variant Toxin by Ohmura-Hoshino, Mari, Ho, Soon-Tae, Kurazono, Hisao, Igarashi, Kazuei, Yamasaki, Shinji, Takeda, Yoshifumi

“…A novel variant of Shiga toxin 1 (Stx1) was identified from bovine Escherichia coli strains. The stx1 variant genes designated as stx1v51 and stx1v52 were…”
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Typing of Verotoxins by DNA Colony Hybridization with Poly- and Oligonucleotide Probes, a Bead-Enzyme-Linked Immunosorbent Assay, and Polymerase Chain Reaction by Yamasaki, Shinji, Lin, Zaw, Shirai, Hiromasa, Terai, Akito, Oku, Yuichi, Ito, Hideaki, Ohmura, Mari, Karasawa, Tadahiro, Tsukamoto, Teizo, Kurazono, Hisao, Takeda, Yoshifumi

“…To identify the type of Verotoxins (VT) produced by Verocytotoxin-producing Escherichia coli (VTEC), a sensitive bead-enzyme-linked immunosorbent assay and…”
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