Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin

Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin, which are biosynthetic intermediates from β-carotene to astaxanthin, were investigated. Both adonirubin and adonixanthin showed almost the same activities for inhibition of lipid peroxidation and q...

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Bibliographic Details
Published in:	Journal of Oleo Science Vol. 62; no. 3; pp. 181 - 186
Main Authors:	Maoka, Takashi, Yasui, Hiroyuki, Ohmori, Aya, Tokuda, Harukuni, Suzuki, Nobutaka, Osawa, Ayako, Shindo, Kazutoshi, Ishibashi, Takashi
Format:	Journal Article
Language:	English
Published:	Japan Japan Oil Chemists' Society 01-03-2013 Japan Science and Technology Agency
Subjects:	9,10-Dimethyl-1,2-benzanthracene - antagonists & inhibitors adonirubin adonixanthin Animals anti-carcinogenic activity anti-oxidative activity anti-tumor-promoting activity Anticarcinogenic Agents - chemistry Anticarcinogenic Agents - metabolism Anticarcinogenic Agents - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antioxidants - chemistry Antioxidants - metabolism Antioxidants - pharmacology Canthaxanthin - analogs & derivatives Canthaxanthin - biosynthesis Canthaxanthin - chemistry Canthaxanthin - pharmacology Carotenoids - biosynthesis Carotenoids - chemistry Carotenoids - pharmacology Cell Line, Tumor Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Female Humans Lipid Peroxidation - drug effects Mice Mice, Inbred ICR Molecular Structure Paracoccus - chemistry Paracoccus - metabolism Singlet Oxygen - chemistry Skin Neoplasms - chemically induced Skin Neoplasms - drug therapy Structure-Activity Relationship Tetradecanoylphorbol Acetate - antagonists & inhibitors Viral Matrix Proteins - antagonists & inhibitors
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Summary:	Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin, which are biosynthetic intermediates from β-carotene to astaxanthin, were investigated. Both adonirubin and adonixanthin showed almost the same activities for inhibition of lipid peroxidation and quenching of singlet oxygen as those of astaxanthin. Furthermore, adonirubin and adonixanthin exhibited an inhibitory effect on Epstein-Barr virus early antigen activation in Raji cells and carcinogensis of mouse skin tumors initiated by 7,12-dimethylbenz[a]anthracene and promoted by 12-O-tetradecanoylphorbol-13-acetate.
ISSN:	1345-8957 1347-3352
DOI:	10.5650/jos.62.181