Search Results - "Ohmi, Takashi"

Orally-Administered Caspase Inhibitor PF-03491390 Is Retained in the Liver for Prolonged Periods With Low Systemic Exposure, Exerting a Hepatoprotective Effect Against α-Fas-Induced Liver Injury in a Mouse Model by Ueno, Yoshinobu, Ohmi, Takashi, Yamamoto, Mitsuko, Kato, Naoto, Moriguchi, Yukiko, Kojima, Midori, Shimozono, Rieko, Suzuki, Sachiko, Matsuura, Tomomi, Eda, Hiroyuki

“…In a mouse model of α-Fas-induced acute liver injury, the orally-administered caspase inhibitor PF-03491390 (formerly named IDN-6556) was retained in the liver…”
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Contribution of Active and Inactive States of the Human 5-HT4d Receptor to the Functional Activities of 5-HT4–Receptor Agonists by Mikami, Tadayoshi, Sugimoto, Hiromi, Naganeo, Rie, Ohmi, Takashi, Saito, Toshiyuki, Eda, Hiroyuki

“…In the present study, binding affinities of 5-hydroxytryptamine-4 (5-HT4) ligands for the human 5-HT4d receptor were determined using the agonist [3H]5-HT and…”
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Ecological studies on the community of drifting seaweeds in the south-eastern coastal waters of Izu Peninsula, central Japan. II: Seasonal changes in plants showing maximum stipe length in drifting seaweed communities by Hirata, Tetsu, Tanaka, Jiro, Iwami, Tetsuo, Ohmi, Takashi, Dazai, Akihiro, Aoki, Masakazu, Ueda, Hajime, Tsuchiya, Yasutaka, Sato, Toshihiko, Yokohama, Yasutsugu

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Synthesis of benzamide derivatives as TRPV1 antagonists by Shishido, Yuji, Jinno, Madoka, Ikeda, Takafumi, Ito, Fumitaka, Sudo, Masaki, Makita, Naoya, Ohta, Atsuko, Iki-Taki, Ayako, Ohmi, Takashi, Kanai, Yoshihito, Tamura, Tetsuya, Shimojo, Masato

“…From hit compounds identified by high throughput screening (HTS), we have found compound 1 as a lead TRPV1 antagonist and confirmed its potential as a…”
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In vitro and in vivo pharmacological characterization of PF-01354082, a novel partial agonist selective for the 5-HT4 receptor by MIKAMI, Tadayoshi, KOMADA, Tohru, EDA, Hiroyuki, SAKAKIBARA, Minoru, SUGIMOTO, Hiromi, SUZUKI, Keiko, OHMI, Takashi, KIMURA, Naoji, NAGANEO, Rie, NAKATA, Eriko, NAKATANI, Keigo, TOGA, Tetsuo

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Pharmacological characterization and determination of pharmacokinetic and pharmacodynamic relationship of PF-00885706, a novel partial agonist selective for the 5-HT4 receptor by Komada, Tohru, Matsuura, Tomomi, Mikami, Tadayoshi, Suzuki, Keiko, Sugimoto, Hiromi, Kimura, Naoji, Ohmi, Takashi, Toga, Tetsuo, Nakai, Yasuhiro, Eda, Hiroyuki

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In vitro and in vivo pharmacological characterization of PF-01354082, a novel partial agonist selective for the 5-HT 4 receptor by Mikami, Tadayoshi, Komada, Tohru, Sugimoto, Hiromi, Suzuki, Keiko, Ohmi, Takashi, Kimura, Naoji, Naganeo, Rie, Nakata, Eriko, Nakatani, Keigo, Toga, Tetsuo, Eda, Hiroyuki, Sakakibara, Minoru

“…The pharmacological profile of PF-01354082, a selective 5-HT 4 receptor partial agonist, was investigated. PF-01354082 displayed high affinity for human 5-HT…”
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Pharmacological characterization and determination of pharmacokinetic and pharmacodynamic relationship of PF-00885706, a novel partial agonist selective for the 5-HT 4 receptor by Komada, Tohru, Matsuura, Tomomi, Mikami, Tadayoshi, Suzuki, Keiko, Sugimoto, Hiromi, Kimura, Naoji, Ohmi, Takashi, Toga, Tetsuo, Nakai, Yasuhiro, Eda, Hiroyuki, Sakakibara, Minoru

“…The pharmacological profile of PF-00885706, a selective 5-HT 4 receptor partial agonist, was investigated. PF-00885706 displayed a high binding affinity for…”
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Synthesis and structure–activity relationships of oxamyl dipeptide caspase inhibitors developed for the treatment of liver disease by Ueno, Hirokazu, Kawai, Makoto, Shimokawa, Hirohisa, Hirota, Masako, Ohmi, Masashi, Sudo, Rie, Ohta, Atsuko, Arano, Yoshimasa, Hattori, Kazunari, Ohmi, Takashi, Kato, Naoto, Kojima, Midori, Ueno, Yoshinobu, Yamamoto, Mitsuko, Moriguchi, Yukiko, Eda, Hiroyuki, Masubuchi, Kazunao

“…P4 derivatives of the oxamyl dipeptide caspase inhibitors are reported. Compounds 29 and 36 exhibited moderate membrane permeability and potent in vivo…”
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Pharmacological characterization and determination of pharmacokinetic and pharmacodynamic relationship of PF-00885706, a novel partial agonist selective for the 5-HT(4) receptor by Komada, Tohru, Matsuura, Tomomi, Mikami, Tadayoshi, Suzuki, Keiko, Sugimoto, Hiromi, Kimura, Naoji, Ohmi, Takashi, Toga, Tetsuo, Nakai, Yasuhiro, Eda, Hiroyuki, Sakakibara, Minoru

“…The pharmacological profile of PF-00885706, a selective 5-HT(4) receptor partial agonist, was investigated. PF-00885706 displayed a high binding affinity for…”
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In vitro and in vivo pharmacological characterization of PF-01354082, a novel partial agonist selective for the 5-HT(4) receptor by Mikami, Tadayoshi, Komada, Tohru, Sugimoto, Hiromi, Suzuki, Keiko, Ohmi, Takashi, Kimura, Naoji, Naganeo, Rie, Nakata, Eriko, Nakatani, Keigo, Toga, Tetsuo, Eda, Hiroyuki, Sakakibara, Minoru

“…The pharmacological profile of PF-01354082, a selective 5-HT(4) receptor partial agonist, was investigated. PF-01354082 displayed high affinity for human…”
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Ecological studies on the community of drifting seaweeds in the south-eastern coastal waters of Izu Peninsula, central Japan. I: Seasonal changes of plants in species composition, appearance, number of species and size by Hirata, Tetsu, Tanaka, Jiro, Iwami, Tetsuo, Ohmi, Takashi, Dazai, Akihiro, Aoki, Masakazu, Ueda, Hajime, Tsuchiya, Yasutaka, Sato, Toshihiko, Yokohama, Yasutsugu

“…SUMMARY Seasonal patterns of drifting seaweeds in the southeastern coastal waters of Izu Peninsula of central Japan were examined by sampling 966 patches from…”
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Ecological studies on the community of drifting seaweeds in the south-eastern coastal waters of Izu Peninsula, central Japan. II: Seasonal changes in plants showing maximum stipe length in drifting seaweed communities by Hirata, Tetsu, Tanaka, Jiro, Iwami, Tetsuo, Ohmi, Takashi, Dazai, Akihiro, Aoki, Masakazu, Ueda, Hajime, Tsuchiya, Yasutaka, Sato, Toshihiko, Yokohama, Yasutsugu

“…SUMMARY The authors examined seasonal patterns in 20 sargas‐saceous species (maximum stipe length of ≥45 cm) from 902 patches of drifting seaweeds in the…”
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Ecological studies on the community of drifting seaweeds in the south-eastern coastal waters of Izu Peninsula, central Japan. I: Seasonal changes of plants in species composition, appearance, number of species and size by Hirata, Tetsu, Tanaka, Jiro, Iwami, Tetsuo, Ohmi, Takashi, Dazai, Akihiro, Aoki, Masakazu, Ueda, Hajime, Tsuchiya, Yasutaka, Sato, Toshihiko, Yokohama, Yasutsugu

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